Associations Between Regional Environment and Cornea-Related Morphology of the Eye in Young Adults: A Large-Scale Multicenter Cross-Sectional Study

Abstract

Purpose To investigate environmental factors associated with corneal morphologic changes. Methods A cross-sectional study was conducted, which enrolled adults of the Han ethnicity aged 18 to 44 years from 20 cities. The cornea-related morphology was measured using an ocular anterior segment analysis system. The geographic indexes of each city and meteorological indexes of daily city-level data from the past 40 years (1980–2019) were obtained. Correlation analyses at the city level and multilevel model analyses at the eye level were performed. Results In total, 114,067 eyes were used for analysis. In the correlation analyses at the city level, the corneal thickness was positively correlated with the mean values of precipitation (highest r [correlation coefficient]: >0.700), temperature, and relative humidity (RH), as well as the amount of annual variation in precipitation ( r : 0.548 to 0.721), and negatively correlated with the mean daily difference in the temperature (DIF T), duration of sunshine, and variance in RH ( r : −0.694 to 0.495). In contrast, the anterior chamber (AC) volume was negatively correlated with the mean values of precipitation, temperature, RH, and the amount of annual variation in precipitation ( r : −0.672 to −0.448), and positively associated with the mean DIF T ( r = 0.570) and variance in temperature ( r = 0.507). In total 19,988 eyes were analyzed at the eye level. After adjusting for age, precipitation was the major explanatory factor among the environmental factors for the variability in corneal thickness and AC volume. Conclusions Individuals who were raised in warm and wet environments had thicker corneas and smaller AC volumes than those from cold and dry ambient environments. Our findings demonstrate the role of local environmental factors in corneal-related morphology.

The Correlation Between Central Corneal Thickness and Intraocular Pressure Among Syrians: A Cross Sectional Study

“…The mean CCT (the mean of males' mean and females' mean) was 544 which was close to the mean reported for subjects of Hispanic descent [24]. This can be explained by the effect of heat and humidity on corneal morphology [29].…”

A Multicenter Study of the Distribution Pattern of Posterior-To-Anterior Corneal Curvature Radii Ratio in Chinese Myopic Patients

“…People who lived at high latitudes for a long time had thinner CCTs and greater ACVs. And individuals who grew up in warm and wet environments had thicker CCTs and smaller ACV (39). It seemed that CCT and ACV had different directions of change in response to ambient environment alteration.…”

Current social determinants of health and social risk factors in conditions of the cornea: a scoping review

“…All included articles and the identified SDoH in each study are summarized in Table 1. Dry eye/ocular surface [18 ▪▪ ,19 ▪ –38 ▪ ] (21 articles) was the most prevalent cornea condition, followed by pterygium [39 ▪▪ ,40 ▪ –42 ▪ ] (4 articles), keratoplasty [43 ▪▪ ,44–46] (four articles), keratoconus [47 ▪ ,48,49] (three articles), cornea donation [50,51 ▪▪ ,52 ▪▪ ] (three articles), cornea thickness [53 ▪ ,54 ▪ ] (two articles), trachoma [55 ▪▪ ,56] (two articles), corneal ulcers [57 ▪ ,58 ▪ ] (two articles), corneal arcus [59 ▪ ] (one article), and corneal opacity[60 ▪ ] (one article). Cornea donation for transplantation was also explored.…”