Purpose: To investigate the distribution of white-to-white (WTW) corneal diameter and anterior chamber depth (ACD) in Chinese myopia patients.Methods: This was a cross-sectional observational study conducted at five ophthalmic centers. Anterior segment biometry was performed in 7,893 eyes of the 7,893 myopic patients using Pentacam, and the WTW and ACD were recorded. The distribution patterns of WTW and ACD were evaluated and the correlation between WTW and ACD was analyzed statistically.Results: There were 4416 (55.95%) males and 3477 (44.05%) females. The age of the study population was 25.14 ± 5.41 years. Distribution of WTW was slightly positively skewed (Skewness = 0.0076, Kurtosis = 0.3944, KS P = 0.020) with a mean of 11.65 ± 0.38 mm and a 95% normal range of 10.91–12.39 mm. A significant difference in WTW was found among different myopia groups (P < 0.001). The ACD was normally distributed (Skewness = 0.899, Kurtosis = 0.027, KS P = 0.086). The mean ACD was 3.25 ± 0.26 mm and the 95% normal range of was 2.74–3.75 mm. A significant difference in ACD was also found among different myopia groups (P = 0.030). There was a significant correlation between WTW and ACD (r = 0.460, P < 0.001).Conclusions: In our study, 95% of the Chinese myopic patients had a WTW within 10.91–12.39 mm and an ACD within 2.74–3.75 mm. ACD and WTW were significantly different among different myopia, gender and age groups. WTW was positively correlated with ACD.
Estimation of corneal refractive power (CRP) is of crucial importance to refractive and cataract surgery. The ratio of posterior to anterior curvature radii of the cornea (P/A ratio) is one of the key factors to determine the actual CRP (True-K). While the traditional method to calculate the CRP (Sim-K) is based on a constant P/A ratio (0.82), it is suggested that the P/A ratio varies in different people and exhibits a distribution pattern, which may have an impact on the accuracy of CRP estimation and postoperative refractive outcome. In this multicenter study, we aimed to investigate the distribution pattern of the P/A ratio in a large number of myopic patients, and further explore the relationship between P/A ratio and ΔK (the difference between True-K and Sim-K). We found that distribution of the P/A ratio ranged from 0.72 to 0.86 with an average value of 0.82 ± 0.01. The compensation effect of the refractive power of the posterior on the anterior surface of the cornea decreased with the increase of P/A ratio. There was a significant correlation between P/A ratio and ΔK in all eyes (r = 0.9764, P < 0.0001). A change of 0.1 in P/A ratio could cause a change of 0.75 D in ΔK. Our study suggests that the actual P/A ratio should be taken into consideration in refractive and cataract surgery when calculating the CRP and power of the intraocular lens in eyes with significantly deviated P/A ratios.
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