Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer

Tao, Yipeng; Wang, Wanling; Li, Songyue; Zhang, Jian; Shi, Qizhong; Zhao, Fen; Zhao, Baosheng

doi:10.1007/s00432-012-1269-0

Cited by 60 publications

(51 citation statements)

References 35 publications

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“…[14][15][16] Primer sequences used in the present study are shown in Table 1 (Bio Basic, Ontario, Canada). [14][15][16] Each PCR reaction mix comprised 55 ng genomic DNA, 200 mM dNTP, 1U Taq DNA polymerase (Fermentas AB, Vilnius, Lithuania) and 100 mM primers, in a total volume of 25 ml. The cycling programme involved preliminary denaturation at 95 C for 5 min, followed by 32 cycles of denaturation at 94 C for 45 s, annealing at 60 C for 45 s, and elongation at 72 C for 45 s, followed by a final elongation step at 72 C for 7 min.…”

Section: Dna Isolation and Genotypingmentioning

confidence: 99%

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

Aytekin¹,

Akçalı

Pehlıvan

et al. 2015

J Int Med Res

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Objective: To investigate the distribution of interleukin (IL)-12 (IL12; 1188A/C), IL17 (A7488G) and IL-23 receptor (IL23R; þ2199A/C) gene polymorphisms in patients with alopecia areata. Methods: Patients with alopecia areata and healthy controls were enrolled in this case-control study. Genotyping of the IL12 (1188A/C), IL17 (A7488G) and IL23R (þ2199A/C) polymorphisms was undertaken. Genotype frequencies were compared between the two groups. Results: The study enrolled 100 patients with alopecia areata and 71 control subjects. No significant differences were found in the frequencies for the IL12 and IL23R gene polymorphisms between the patient and control groups. The IL17 GG genotype was significantly more common and the IL17 GA genotype was significantly less common in patients with alopecia areata compared with controls, but only 10% of patients had the GG genotype. Conclusion: The IL17 GG genotype was associated with susceptibility for alopecia areata, but this genotype was only present in a small number of patients. The IL12 and IL23R gene polymorphisms were not found to have a significant association with alopecia areata.

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Section: Dna Isolation and Genotypingmentioning

confidence: 99%

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

Aytekin¹,

Akçalı

Pehlıvan

et al. 2015

J Int Med Res

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“…The -964A/G polymorphism (rs153109) of IL-27p28 gene promoter was first identified in a case-control study and showed a relationship with asthma susceptibility (6). After that, several case-control studies were conducted to investigate the association between IL-27p28 gene -964A/ G polymorphism and cancer risk in Chinese population (7)(8)(9)(10)(11)(12)(13)(14). However, conflicting results were observed, which might be caused by small sample size of each individual study.…”

Section: Introductionmentioning

confidence: 99%

Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis

Hua

Chao

et al. 2017

Journal of Receptors and Signal Transduction

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IL-27 plays an important role in anti-cancer activity. The -964A/G polymorphism in IL-27 gene has been implicated in susceptibility to cancer, but the results were conflicting. The aim of this study was to assess the association between this polymorphism and cancer risk. Pubmed and Wanfang database were searched for all publications concerning IL-27 -964A/G polymorphism and cancer risk. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. Statistical analysis was performed using Stata 11.0 software. A total of eight case-control studies including 2044 cancer cases and 2197 controls were identified. Overall, significant association between IL-27 -964A/G polymorphism and cancer risk was observed (GG versus AA: OR ¼ 1.26, 95% CI ¼ 1.03-1.52; GG versus AG + AA: OR ¼ 1.20, 95% CI ¼ 1.00-1.44). In subgroup analysis based on cancer type, significant association was found in colorectal cancer (GG versus AA: OR ¼ 1.55, 95% CI ¼ 1.07-2.27; AG versus AA: OR ¼ 1.31, 95% CI ¼ 1.02-1.67). The current meta-analysis suggests that IL-27 -964A/G polymorphism might enhance cancer risk. However, large-scale and well-designed studies are still needed to confirm the result of our meta-analysis. The association of IL-27 polymorphism with colorectal cancer may provide insight for future therapies.

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“…It was only shown that the IL12B rs3212227 SNV affected the circulating levels of IL-12 p40. 29,30 Among other immune response abnormalities in uremic patients, the secretion of IL-12 was reported to be disturbed. In vitro studies showed that dendritic cells of HD patients secrete more IL-12 p70, the active form of IL-12 (after incubation both in uremic serum and serum of healthy individuals), and that the functioning of these cells is significantly impaired.…”

mentioning

confidence: 99%

Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

Jodłowska-Siewert¹,

Jagodzińśki²,

Grzegorzewska³

2017

Polish Archives of Internal Medicine

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Associations between polymorphisms in IL-12A, IL-12B, IL-12Rβ1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer

Cited by 60 publications

References 35 publications

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

Investigation of interleukin-12, interleukin-17 and interleukin-23 receptor gene polymorphisms in alopecia areata

Genetic association between IL-27 rs153109 polymorphism and cancer risk in Chinese population: a meta-analysis

Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

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