Titers of antibodies to the surface antigen of hepatitis B virus after vaccination in relation to immunity-related gene variants. A prospective study among hemodialysis patients

Jodłowska-Siewert, Elżbieta; Jagodzińśki, Paweł P.; Grzegorzewska, Alicja E.

doi:10.20452/pamw.4074

Cited by 3 publications

(2 citation statements)

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“…In general, the immune response to the HB vaccine decreased over time. Nevertheless, there has been a higher decrease in the mean of the serum level of HBsAb in HD patients than in the general population, and this reduction has increased more in HD patients [8,13,19]. In this study, like similar ones, the number of dialysis per week was not associated with the rate of the response to HBV [3].…”

Section: Discussionsupporting

confidence: 57%

“…Hemodialysis (HD) patients are at an increased risk of acquiring HBV. Despite the completion of their vaccination schedule, they have lower seroconversion rates, lower protective antibody levels, and shorter seroprotection durations [6][7][8]. While the rate of the response to the HB vaccine is 90% among healthy people, it is 50-70% among HD patients [1,9].…”

Section: Introductionmentioning

confidence: 99%

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An Investigation of the Immune Response to Hepatitis B Vaccination in Hemodialysis Patients at Dialysis Centers of Tehran (2016)

Hatami

Movafagh

Ramezankhani

2019

JOHE

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Article Info Background: Hemodialysis (HD) patients are at an increased risk of acquiring the hepatitis B (HB) virus and having lower protective antibody levels as well as shorter durations of seroprotection. This study aims to determine the immune response of HB vaccination in HD patients referring to dialysis centers of the Tehran North Health Network. Materials and Methods: This descriptive study was conducted among all HD patients who referred to dialysis centers of the Tehran North Health Network in 2016. A total of 304 HD patients were included in this study using the census sampling method. Data were collected using a checklist, and the HBsAb level was evaluated by the ELISA test. The collected data were analyzed using analytical tests, including a chi-square test and the independent t-test. Results: The mean±sd values of the serum level of HBsAb were 90.44±97.51 and 105.73±100 IU/L in men and women, respectively. There was no association between the rate of the response to the HB vaccine and gender (P=0.82), age (P=0.13), weight (P=0.09), vaccine injection frequency (P=0.45), number of dialysis sessions/week (P=0.36), and blood type (P=0.97). In addition, there was no association between the response to the HB vaccine and the history of T2DM, HTN, renal transplantation, and cigarette smoking among the participants (P>0.05). Conclusion: One could conclude that the dialysis duration and the last injection of the HB vaccine would have a negative effect on the immune response rate among HD patients.

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Section: Discussionsupporting

confidence: 57%