Associations between persistent organic pollutants and risk of breast cancer metastasis

Koual, Meriem; Cano-Sancho, Germán; Bats, Anne‐Sophie; Tomkiewicz, Céline; Kaddouch-Amar, Yael; Douay-Hauser, Nathalie; Ngô, Charlotte; Bonsang, Hélène; Deloménie, M; Lécuru, Fabrice; Bizec, Bruno Le; Marchand, Philippe; Botton, Jérémie; Barouki, Robert; Antignac, Jean‐Philippe; Coumoul, Xavier

doi:10.1016/j.envint.2019.105028

Cited by 73 publications

(46 citation statements)

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“…Among women with ER- tumors: OR = 3.24 (95% CI = 1.38–7.58) Among women with ER+ tumors: OR = 1.29 (95% CI = 0.73–2.28) (PInteraction = 0.03). Exposure to DDE/DDT may impact overall and breast cancer-specific survival 2019 France [ 56 ] Case control 91 women newly diagnosed with breast cancer 53 nonmetastatic and 38 metastatic (lymph node involvement) 49 persistent organic pollutants including PCB, PBDE, PBB and HBCD Serum and adipose peritumoral tissue At diagnosis; 2013–2017 Association between pollutants concentrations and lymph node involvement 2.3.7.8-TCDD concentrations in adipose tissue are associated with the risk of lymph node metastasis in patients with BMIs equal or higher than 25 kg/m2 OR = 4.48 (95%CI = 1.32–20.71) 2.3.7.8-TCDD concentrations and PCB 77 and 169 in adipose tissue are associated with risk of lymph node metastasis and tumor size 2.3.7.8-TCDD could contribute to the development of tumor metastasis in overweight patients …”

Section: Results Of Reviewmentioning

confidence: 99%

“…2.3.7.8-TCDD (named TCDD) is one of the most potent carcinogens ever tested and it is the most active congener within the group of AHR agonists. A recent epidemiological study of BC patient showed that TCDD concentrations in adipose tissue are associated with the risk of lymph node metastasis, especially in patients with BMIs equal or higher than 25 kg/m 2 (OR = 4.48, 95%CI = 1.32–20.71) [ 56 ]. As described previously, the role of AHR in cancer progression and metastasis is complex and still controversial.…”

Section: Results Of Reviewmentioning

confidence: 99%

“…Seven epidemiological studies, between 2000 and 2019, investigated a potential link between PCB concentrations and BC prognostics factors or BC recurrence/survival. At diagnosis, the concentrations of PCBs were measured in serum and, in three studies, in breast adipose tissue [ 56 , 58 – 63 ]. Demers et al found that the concentration of PCB 153 was associated with an increased risk of lymph node involvement (OR = 2.12 95% CI = 1.5–4.3) in a first study [ 58 ].…”

Section: Results Of Reviewmentioning

confidence: 99%

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Environmental chemicals, breast cancer progression and drug resistance

Koual¹,

Tomkiewicz²,

Cano-Sancho³

et al. 2020

Environ Health

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127

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Breast cancer (BC) is one of the most common causes of cancer in the world and the second leading cause of cancer deaths among women. Mortality is associated mainly with the development of metastases. Identification of the mechanisms involved in metastasis formation is, therefore, a major public health issue. Among the proposed risk factors, chemical environment and pollution are increasingly suggested to have an effect on the signaling pathways involved in metastatic tumor cells emergence and progression. The purpose of this article is to summarize current knowledge about the role of environmental chemicals in breast cancer progression, metastasis formation and resistance to chemotherapy. Through a scoping review, we highlight the effects of a wide variety of environmental toxicants, including persistent organic pollutants and endocrine disruptors, on invasion mechanisms and metastatic processes in BC. We identified the epithelial-to-mesenchymal transition and cancer-stemness (the stem cell-like phenotype in tumors), two mechanisms suspected of playing key roles in the development of metastases and linked to chemoresistance, as potential targets of contaminants. We discuss then the recently described pro-migratory and pro-invasive Ah receptor signaling pathway and conclude that his role in BC progression is still controversial. In conclusion, although several pertinent pathways for the effects of xenobiotics have been identified, the mechanisms of actions for multiple other molecules remain to be established. The integral role of xenobiotics in the exposome in BC needs to be further explored through additional relevant epidemiological studies that can be extended to molecular mechanisms.

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Section: Results Of Reviewmentioning

confidence: 99%

Section: Results Of Reviewmentioning

confidence: 99%

Section: Results Of Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Environmental chemicals, breast cancer progression and drug resistance

Koual¹,

Tomkiewicz²,

Cano-Sancho³

et al. 2020

Environ Health

Self Cite

127

View full text Add to dashboard Cite

show abstract

“…More than 85% of breast cancers are sporadic and potentially attributable to long-term exposure to environmental factors, such as chemical carcinogens (1)(2)(3)(4)(5). Given the increasing evidence that common environmental carcinogens play a significant role in breast cancer, increased attention has been paid to molecular mechanisms through which pollutants affect breast tumor formation, progression, and/or invasion (6)(7)(8). The identification of such molecular mechanisms could have several societal and environmental consequences, and may lead to the discovery of human biomarkers of exposure to environmental carcinogens exploitable for breast cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

et al. 2020

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“…The mean age at diagnosis lies between the fourth and fifth decades of life (i.e., the perimenopausal age group) [ 8 , 9 ]. The median tumor size is reported to range from 3.4 to 5.7 cm in various series [ 10 - 12 ]. Axillary node involvement is usually less frequent in comparison to invasive ductal carcinoma (IDC), although it differs across case series.…”

Section: Discussionmentioning

confidence: 99%

A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

Lakshmi¹,

Saini²,

Prakash³

et al. 2020

Cureus

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Carcinosarcoma, also known as metaplastic carcinoma, is a rare and aggressive malignant tumor. We report a case of metaplastic carcinoma presenting as inflammatory carcinoma and provide a review of the related literature. A 38-year-old breastfeeding woman presented with concerns about a painful lump in her left breast. The symptoms had been present for two months. After admission to the hospital, the triple assessment revealed findings consistent with inflammatory carcinoma of the breast. The patient underwent modified radical mastectomy. Histopathological examination revealed a gray-white tumor with a biphasic pattern with features of ductal carcinoma as well as squamous and sarcomatous differentiation. On immunohistochemistry, the neoplastic cells were positive for cytokeratin and vimentin, and focally positive for smooth muscle antigen (SMA) and negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor (HER-2/neu). Based on histological and immunohistochemical findings, the tumor was diagnosed as carcinosarcoma. Four of eighteen dissected axillary lymph nodes were positive for metastasis. Carcinosarcoma is often a triple-negative tumor. The lack of standardized treatment protocols frequently leads to poor prognosis and can pose a diagnostic dilemma; it should be part of the differential diagnosis for a case of carcinoma of the breast presenting as inflammatory carcinoma.

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Associations between persistent organic pollutants and risk of breast cancer metastasis

Cited by 73 publications

References 50 publications

Environmental chemicals, breast cancer progression and drug resistance

Environmental chemicals, breast cancer progression and drug resistance

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay

A Case of Carcinosarcoma of the Breast Presenting as Inflammatory Carcinoma and Review of the Literature

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