Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis

Richardson, Sandra D.; Browne, Marilyn L.; Rasmussen, Sonja A.; Druschel, Charlotte M.; Sun, Lin; Jabs, Ethylin Wang; Romitti, Paul A.

doi:10.1002/bdra.20823

Cited by 52 publications

(57 citation statements)

References 26 publications

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“…Most previous studies identified advanced maternal age as a risk factor for craniosynostosis [15,26,29,30] while a few [2,18], like ours, failed to show this association. This could have been due to the average young maternal age in our study and that the mothers did not make use of fertility assistance.…”

Section: Discussioncontrasting

confidence: 58%

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Risk Factors Associated with Craniosynostosis: A Case Control Study

et al. 2012

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Background: Craniosynostosis is a relatively common congenital abnormality. The underlying etiology and most probable risk factors of nonsyndromic craniosynostosis are unknown. We conducted a study to identify the risk factors for craniosynostosis. Materials and Methods: In this case-control project, 70 children with craniosynostosis (syndromic or nonsyndromic) hospitalized at the Children's Hospital Medical Center from September 2010 to 2011 were studied for the potential risk factors. At the same time, 70 age- and sex-matched children hospitalized with other congenital anomalies were reviewed. Information from case and control groups was obtained via personal interviews with parents of patients and a prepared checklist was filled out for each child. Results: The mean (±SE) age at admission time in the case-control group was 13 ± 1.95 (1.5-96) months, and almost half of them were boys (n = 37 or 53%). The most frequent sutures involved in craniosynostosis were coronal (n = 30 or 42.9%) and then metopic sutures (n = 16 or 22.9%), multiple (n = 12 or 17.1%), sagittal (n = 11 or 15.7%) and lambdoid (n = 1 or 1.4%). In the case group, maternal diabetes mellitus and thyroid disease were found in 8 (11.6%) and 6 (8.6%) patients, respectively. The most frequent medication used by mothers (n = 66 or 94%) in the case group during pregnancy were vitamins (including iron supplements, omega 3, folic acid and multivitamins). Conclusion: A positive family history of craniosynostosis [odds ratio (OR) 19.01 and 95% confidence interval (CI) 2.24-160.7] and using clomiphene citrate for infertility (OR 12.71 and 95% CI 1.42-113.6) were the strongest independent risk factors for craniosynostosis. More comprehensive studies with a larger sample size are required to confirm the role of environmental factors in order to decrease the occurrence of craniosynostosis.

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Section: Discussioncontrasting

confidence: 58%

“…Although Richardson et al [30 ]found an association between alcohol consumption after the first trimester and craniosynostosis, most previous studies fail to show such an association [26,] as was also the case in our study.…”

Section: Discussioncontrasting

confidence: 52%

Risk Factors Associated with Craniosynostosis: A Case Control Study

et al. 2012

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“…Infants born to mothers with reported maternal diseases, such as gestational diabetes mellitus (13,14), hypertension (15), and thyroid disorders (16,17), or adverse environmental exposure (18)(19)(20)(21)(22) during pregnancy, were excluded from this analysis because of the possible association of these factors with birth defects. The final data, involving 2,060 live-born infants, delivered after IVF with ICSI and FET, were stratified into groups according to the method of ovarian stimulation: 587 births after LPS, 1,257 births after the standard GnRH-a short protocol, and 216 births after mild ovarian stimulation.…”

Section: Study Population and Designmentioning

confidence: 99%

Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles

Chen

Wang

Lyu

et al. 2015

Fertility and Sterility

126

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“…The toxic effects of alcohol on the fetus have been known for more than 40 years (39) and consumption of alcohol during pregnancy is associated with congenital birth defects (23,40) as well as unfavourable developmental (20) and neurological outcomes (16) . The consequences of low to moderate alcohol consumption during pregnancy are somewhat contradictory, with some researchers reporting no effect on child behaviour or development (17,21) whereas others report significant negative effects (5) .…”

Section: Alcoholmentioning

confidence: 99%

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

Skreden

Bere

Sagedal

et al. 2014

Public Health Nutr.

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Objective: To describe changes in consumption of different types of beverages from pre-pregnancy to early pregnancy, and to examine associations with maternal age, educational level and BMI. Design: Cross-sectional design. Participants answered an FFQ at inclusion into a randomized controlled trial, the Fit for Delivery (FFD) trial, in median gestational week 15 (range: 9-20), reporting current consumption and in retrospect how often they drank the different beverages pre-pregnancy. Setting: Eight local antenatal clinics in southern Norway from September 2009 to February 2013. Subjects: Five hundred and seventy-five healthy pregnant nulliparous women. Results: Pre-pregnancy, 27 % reported drinking alcohol at least once weekly, compared with none in early pregnancy (P < 0·001). The percentage of women drinking coffee (38 % v. 10 %, P < 0·001), sugar-sweetened beverages (10 % v. 6 %, P = 0·011) and artificially sweetened beverages (12 % v. 9 %, P = 0·001) at least daily decreased significantly from pre-pregnancy to early pregnancy, while the percentage of women who reported to drink water (85 % v. 92 %, P < 0·001), fruit juice (14 % v. 20 %, P = 0·001) and milk (37 % v. 42 %, P = 0·001) at least daily increased significantly. From pre-pregnancy to early pregnancy higher educated women reduced their consumption frequency of coffee significantly more than women with lower education. Older women reduced their consumption frequency of coffee and artificially sweetened beverages and increased their consumption frequency of fruit juice and milk significantly more than younger women. Conclusions: There is a significant change in beverage consumption from pre-pregnancy to early pregnancy among Norwegian nulliparous women.

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Associations between periconceptional alcohol consumption and craniosynostosis, omphalocele, and gastroschisis

Abstract: Results suggest that maternal periconceptional alcohol consumption is associated with omphalocele and gastroschisis, and second and third trimester alcohol consumption are inversely associated with craniosynostosis.

Cited by 52 publications

References 26 publications

Risk Factors Associated with Craniosynostosis: A Case Control Study

Risk Factors Associated with Craniosynostosis: A Case Control Study

Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles

Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study

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