Associations between novel genetic variants in the promoter region of<i>MALAT1</i>and risk of colorectal cancer

Li, Yingjun; Bao, Chengzhen; Gu, Simeng; Ding, Ye; Jing, Fangyuan; Fan, Chunhong; Jin, Mingjuan; Chen, Kun

doi:10.18632/oncotarget.21507

Cited by 44 publications

(34 citation statements)

References 56 publications

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“…In addition, the study from Li et al also confirmed the rs1194338 polymorphism (C>A) was significantly associated with a reduced risk of CRC, which is more obvious protection in the subgroup. Further analysis showed that although MALAT1 was over-expressed in CRC tissues, the expression difference was not significant between CC and AA genotype of rs1194338 in CRC tissues [38]. Similar to Li's study, we observed the expression of the MALAT1 in IS group was higher significantly than normal group, but expression difference between the AC/AA and CC genotype were not significant (figure 1).…”

Section: Discussionsupporting

confidence: 81%

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

wang

Huang

et al. 2019

Preprint

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Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases including ischemic stroke (IS). This study aimed to investigate the association between MALAT1 polymorphism and IS risk. We performed the genotyping of rs600231, rs1194338, rs4102217 and rs591291 in the promoter of MALAT1 by SNPscan method. Quantitative PCR was used to determine the levels of MALAT1 relative expression. We found the rs1194338 C>A variant in MALAT1 promoter was associated with IS risk (AC vs. CC: adjusted OR = 0.623, 95% CI, 0.417-0.932, P = 0.021; AA vs. CC: adjusted OR = 0.474, 95% CI, 0.226-0.991, P = 0.047; AC/AA vs. CC: adjusted OR = 0.596, 95% CI, 0.406-0.874, P = 0.008; A vs. C adjusted OR = 0.658, 95% CI, 0.487-0.890, P = 0.007). The IS patients showed higher expression levels of MALAT1 compared with the control group ( P < 0.05), but patients with AC/AA genotypes of rs1194338 have no significant difference compared to CC genotype ( P > 0.05). In addition, no significant differences were observed in blood lipid levels among SNPs of MALAT1 ( P > 0.05). These results suggest that the rs1194338 AC/AA genotypes may be a protective factor for IS, which mechanism needs to be further explored.

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Section: Discussionsupporting

confidence: 81%

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

wang

Huang

et al. 2019

Preprint

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“…It was reported that genetic variation in promoter region will in uence transcriptome expression, stability and subcellular localization, leading to functional changes and the occurrence of disease [42]. However, rs1194338 polymorphism did not alter the MALAT1 expression levels in colorectal cancer tissues [26]. In addition, there was no statistically signi cant difference in MALAT1 expression between CC genotype and AA genotype [43].…”

Section: Discussionmentioning

confidence: 90%

“…Based on the selection criteria, 12 studies [17][18][19][20][21][25][26][27][28][29][30][31] were included in this meta-analysis ( Fig. 1).…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

Association Between LncRNA MALAT1 Polymorphisms and Cancer Risk: A Meta-Analysis Based on7007 Cases and 8791 Controls

Rong

Cheng

2020

Preprint

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Background: LncRNA metastasis associated with lung adenocarcinoma transcript-1 (MALAT1) was involved in pathogenesis and progress of diverse cancers. To investigate the association of MALAT1 and cancer susceptibility, this meta-analysis was appraised.Methods: 12 studies including 7007 cancer patients and 8791 controls were selected for this meta-analysis. Ratio radiation (ORS) and 95% confidence interval (CIS) were used to assess cancer susceptibility.Results: There was no significant association between rs3200401 polymorphism and the risk of cancer. However, rs3200401 was correlated with an increased risk of digestive cancer in allelic model (OR=1.15, 95%CI=1.04-1.28, P=0.009) and dominant model (OR=1.16, 95%CI=1.02-1.31, P=0.02). There was a borderline association between rs664589 and cancer susceptibility under the dominant model (OR=1.17, 95%CI=1.00-1.38, P=0.05). Rs619586 was associated with decreased cancer risk in all populations under four models (G vs A: OR=0.86, 95%CI=0.78-0.94, P=0.001; GG vs AA: OR=0.60, 95%CI=0.42-0.84, P=0.003; GG+AG vs AA: OR=0.87, 95%CI=0.78-0.97, P=0.009; GG vs AG+AA: OR=0.61, 95%CI=0.44-0.84, P=0.003). Moreover, rs1194338 was decreased associated with cancer susceptibility (A vs C: OR=0.89, 95%CI=0.80-0.98, P=0.01; AA vs CC: OR=0.77, 95%CI=0.62-0.96, P=0.02; AA+AC vs CC: OR=0.87, 95%CI=0.77-1.00, P=0.04; AA vs AC+CC: OR=0.82, 95%CI=0.67-1.00, P=0.05).Conclusion: Our results suggest that rs619586 and rs1194338 are associated with decreased cancer risk, while rs3200401 and rs664589 correlated with increased digestive cancer risk.

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“…This suggested there was an interactive function between rs1194338 and the environment, whether it interacts with the environment in IS remains to be further explored. In colorectal cancer, previous study found carriers with AA and AC genotype of the rs1194338 were lower risk than CC genotype, and the conclusion from Li's study showed no statistically significant difference in expression levels of MALAT1 between CC and AA genotype at rs1194338 [33,34].…”

Section: Discussionmentioning

confidence: 91%

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Wang

Huang

et al. 2020

Preprint

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Background: Metastasis-associated lung adenocarcinoma transcript-1 (MALAT1) was aberrantly expressed in diverse diseases, and especially plays an important role in nerve injury including promotion of angiogenesis, inhibition of apoptosis and inflammation, regulation of autophagy, which are closely linked to the pathological processes of ischemic stroke (IS). However, the effect of genetic variation (single nucleotide polymorphisms, SNPs) of MALAT1 on IS have rarely been explored. This study aimed to investigate whether polymorphisms in promoter of MALAT1 were associated with the susceptibility to IS. Methods: A total of 316 IS patients and 320 age-, gender-, and ethnicity-matched controls were enrolled in this study. Four polymorphisms in the promoter of MALAT1 (i.e., rsrs600231, rs1194338, rs4102217, and rs591291) were genotyped using a custom‐by‐design 48‐Plex SNPscan kit. Results: The rs1194338 C>A variant in MALAT1 promoter was associated with IS risk (AC vs. CC: adjusted OR = 0.623, 95% CI, 0.417-0.932, P = 0.021; AA vs. CC: adjusted OR = 0.474, 95% CI, 0.226-0.991, P = 0.047; Dominant model: adjusted OR = 0.596, 95% CI, 0.406-0.874, P = 0.008; A vs. C adjusted OR = 0.658, 95% CI, 0.487-0.890, P = 0.007). The Haplotype analysis showed that rs600231-rs1194338-rs4102217-rs591291 (A-C-G-C) had a 1.3-fold increase of IS risk (95% CI, 1.029-1.644, P=0.027). Logistic regression analysis identified some independent impact factors for IS including rs1194338 AC/AA, TC, TG, HDL-C, LDL-C, Apo-A1, Apo-B and NEFA(P < 0.05). Conclusions: These results suggest that the rs1194338 AC/AA genotypes may be a protective factor for IS.

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Associations between novel genetic variants in the promoter region ofMALAT1and risk of colorectal cancer

Cited by 44 publications

References 56 publications

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

Association Between LncRNA MALAT1 Polymorphisms and Cancer Risk: A Meta-Analysis Based on7007 Cases and 8791 Controls

A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke

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