Associations between newly discovered polymorphisms of the Myod1 gene and body parameters in Stavropol breed rams

Trukhachev, Vladimir; Skripkin, V.S.; Telegina, E.Yu.; Yatsyk, Olesya; Golovanova, Natalia; Krivoruchko, Alexander

doi:10.15547/bjvm.1069

Cited by 3 publications

(4 citation statements)

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“…A small sample size of Santa Inês sheep breed was studied here, but the genotype and allele frequencies obtained were very similar to the other sheep breeds reported earlier. For example, the SNP g.34302967A>G, located in exon 3, was also identified in the Stavropol sheep by Trukhachev et al (2018), who reported frequencies of 17% for G allele and 0.0% for GG genotype. These values were very close to those found for Santa Inês in the current study, which was 19.1% (G) and 3.5% (GG).…”

Section: Resultsmentioning

confidence: 99%

“…Variants in the MyoD1 gene were associated with body traits in Stavropol sheep (Trukhachev et al, 2018), while Lôbo et al (2012) observed an association between MyoD1 gene expression in Longissimus muscle and carcass yield of Santa Inês, Morada Nova, and Somalis sheep. Additionally, positive correlations between MyoG expression and body and carcass weights in Hu sheep were found (Sun et al, 2010), while MyoG variants were associated with body weight in beef cattle (Bhuiyan et al, 2009), and intramuscular fat in pigs (Stupka et al, 2012).…”

Section: Introductionmentioning

confidence: 98%

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Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

Sousa

Meira

Azevedo

et al. 2019

Pesq. agropec. bras.

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The objective of this work was to sequence the MyoD1, MyoG, MyF5, MyF6, and MSTN genes and to identify polymorphisms in Santa Inês sheep (Ovis aries). A total of 192 lambs with 240 days of age were evaluated, and these genes were sequenced to be compared with the reference sequence in the Ovis aries genome. Genotype and allele frequencies were estimated, and the Hardy-Weinberg equilibrium was tested. Fragments containing 2,493 bp (MyoD1), 1,836 bp (MyoG), 2,813 bp (MyF5), 1,126 bp (MyF6), and 2,380 bp (MSTN) were obtained, and, in these sequences, 160 variants were identified. These polymorphisms were distributed as follows: 59 (MyoD1), 24 (MyoG), 63 (MyF5), 4 (MyF6), and 10 (MSTN). One hundred and four were novel polymorphisms, 45 in MyoD1, 2 in MyoG, 56 in MyF5, and 1 in MSTN. Regarding site, 61 were in intron (27 in MyoD1, 16 in MyoG, 5 in MyF5, 3 in MyF6, and 10 in MSTN), 87 in coding region (22 in MyoD1, 8 in MyoG, 56 in MyF5, and 1 in MyF6), and 12 on 3’UTR (10 in MyoD1 and 2 in MyF5). Therefore, the MyoD family and MSTN genes have several polymorphisms in Santa Inês sheep, which can be useful for association studies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

Sousa

Meira

Azevedo

et al. 2019

Pesq. agropec. bras.

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“…10 In sheep, variants in MyoD1 were reported as being associated with body traits such as thoracic girth and loin width in Stavropol sheep. 11 Additionally, positive correlations between MyoG expression and body and carcass weights in Hu sheep were found. 12 Moreover, variants in the MyF5 gene were associated with lean meat yield in both leg and loin cuts in New Zealand Romney sheep.…”

Section: Introductionmentioning

confidence: 89%

“…Although no study has associated variants in the MyoD1 gene with the type or density of muscle fibers in sheep, the association between variants in this gene and muscle growth in sheep has been reported. An association of the rs412308724 variant in MyoD1 with loin width and chest girth was reported for Stavropol sheep, 11 while a positive correlation between MyoD1 expression and cold carcass yield in Brazilian hair sheep (including Santa Inês sheep) was reported. 41 These results revealed the vital role of the MyoD1 gene in muscle mass increase, which can affect physical meat traits, as observed for Santa Inês sheep.…”

Section: Association Analysismentioning

confidence: 98%

Variants in myostatin and MyoD family genes are associated with meat quality traits in Santa Inês sheep

Sousa

Meira

Azevedo

et al. 2020

Animal Biotechnology

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Myostatin and MyoD family genes play vital roles in myogenesis and this study aimed to identify association of variants in MyoD1, MyoG, MyF5, MyF6, and MSTN genes with meat traits in Santa Inês sheep. A dataset with 44 variants and records of seven meat traits in 192 lambs (pH0, pH24, a Ã , b Ã , L Ã , tenderness assessed by shear force, and water-holding capacity) was used. Single-locus and haplotype association analyses were performed, and the significance threshold was established according to Bonferroni's method. Single-locus analysis revealed two associations at a Bonferroni level, where the variant c.935-185C > G in MyoD1 had an additive effect (À4.31 ± 1.08 N) on tenderness, while the variant c.464 þ 185G > A in MyoG had an additive effect (À2.86 ± 0.64) on a Ã . Additionally, the haplotype replacement GT>AC in MSTN was associated with pH0 (1.26 ± 0.31), pH24 (1.07 ± 0.27), a Ã (À1.40 ± 0.51), and tenderness (3.83 ± 1.22 N), while the replacement GT > AG in MyoD1 was associated with pH0 (1.43 ± 0.26), pH24 (1.25 ± 0.22), b Ã (À1.06 ± 0.39), and tenderness (À4.13 ± 1.16 N). Our results have demonstrated that some variants in MyoG, MyF6, MyoD1, and MSTN can be associated with physicochemical meat traits in Santa Inês sheep.

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Genetic variation in the bovine myogenic determination factor 1 (g.782G>A polymorphism) and its influence on carcass traits in Turkish Grey Steppe cattle

Ardıçlı¹,

Cobanoglu²

2021

Turk J Vet Anim Sci

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Associations between newly discovered polymorphisms of the Myod1 gene and body parameters in Stavropol breed rams

Cited by 3 publications

References 24 publications

Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

Polymorphisms in MyoD1, MyoG, MyF5, MyF6, and MSTN genes in Santa Inês sheep

Variants in myostatin and MyoD family genes are associated with meat quality traits in Santa Inês sheep

Genetic variation in the bovine myogenic determination factor 1 (g.782G>A polymorphism) and its influence on carcass traits in Turkish Grey Steppe cattle

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