Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis

Xu, Ping; Liu, Aiping; Li, Fengna; Tinkov, Alexey A.; Liu, Longjian; Zhou, Jinchuan

doi:10.1016/j.envpol.2021.116480

Cited by 50 publications

(23 citation statements)

References 130 publications

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“…Our previous study demonstrated a significant BMI-associated increase in hair Cd, Hg, Pb, and Sn in adults [21]. However, in a recent meta-analysis of the existing data, we demonstrated the association between Pb and Hg, but not As and Cd, with metabolic syndrome [22].…”

Section: Discussioncontrasting

confidence: 52%

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Skalny

Kopylov

Paoliello

et al. 2021

IJERPH

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The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control (n = 123) and obese groups (n = 140). Patients suffering from CHD were divided into normal weight (n = 180) and obese CHD subjects (n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.

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Section: Discussioncontrasting

confidence: 52%

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Skalny

Kopylov

Paoliello

et al. 2021

IJERPH

Self Cite

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“… 83 Heavy metals may also play an essential role in the development of not only cardiovascular complications 84 but also MetS, which due to the development of industry, traffic, smoking or changes in food production technology, constitute an imperative element of environmental pollution, also among residents of rural areas. 85 Heavy metals influencing the higher risk of metabolic syndrome turned out to be, among others, mercury, 86 arsenic, cadmium, lead, 87 copper and zinc. 88 The last important piece of the puzzle of environmental factors that may potentially cause exposition to the more frequent occurrence of MetS is air pollution, as demonstrated in the research by, for example, Zhang et al, 89 Yang et al 90 or Matthiessen et al 91 MetS is associated with the development of many other diseases.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study

Nowicki¹,

Ślusarska²,

Naylor³

et al. 2021

DMSO

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“…With rapid development and disparity between the economy and culture, changes in the traditional dietary structure and lifestyle have varied substantially in different places in China in the last 10 years,8–12 with aggregated effects in certain areas 13–17. As most previous studies on the factors affecting MS in China were based on small unrepresentative samples,18 more analyses based on regionally or nationally representative data are needed. In addition, studies in China to date have not taken into account the effects of environmental factors, such as socioeconomic factors, on MS.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of metabolic syndrome among the adult population in western China and the association with socioeconomic and individual factors: four cross-sectional studies

Zeng

Yang

et al. 2022

BMJ Open

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ObjectivesThis study explored the prevalence of and individual influencing factors for metabolic syndrome (MS) as well as associated socioeconomic factors and regional aggregation.DesignFour cross-sectional surveys were analysed for trends in MS and associations with socioeconomic and individual factors through multilevel logistic regression analyses. The risk associated with nutrient intake was also assessed through a dietary survey in 2015.SettingFrom 2010 to 2018, 8–15 counties/districts of West China were included.ParticipantsA total of 28 274 adults were included in the prevalence analysis. A total of 23 708 adults were used to analyse the related factors.ResultsThe overall prevalence of MS ranged from 21.4% to 27.8% over the 8 years, remaining basically stable within the 95% CI. Our study found that the urbanisation rate and hospital beds per 1000 people were positively associated with MS, and the number of doctors in healthcare institutions per 1000 persons was negatively associated with MS. The ORs for females, people with college education and higher and unmarried or single people were 1.49, 0.67 and 0.51, respectively (p<0.05). The ORs of people who smoked at least 20 cigarettes/day, ate more than 100 g of red meat/day, consumed fruit or vegetable juice and drank carbonated soft drinks less than weekly were 1.10, 1.16, 1.19–1.27 and 0.81–0.84, respectively. The ORs rose with increasing sedentary time and decreased with higher physical activity.ConclusionThe high burden of MS, unreasonable proportions of energy and micronutrient intake and low percentage of high levels of physical activity were the major challenges to public health in western China. Improving the human resources component of medical services, such as the number of doctors, increasing the availability of public sports facilities and E-health tools and improving individual dietary quality and education might help prevent MS.

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Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis

Cited by 50 publications

References 130 publications

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study

Prevalence of metabolic syndrome among the adult population in western China and the association with socioeconomic and individual factors: four cross-sectional studies

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