Associations between maternal anthropometric characteristics and infant birth weight in Iranian population

Abstract

Objective:To examine the (1) normal ranges of anthropometric and insulin resistance/sensitivity indices (homeostatic model assessment for insulin resistance, homeostatic model assessment for insulin sensitivity, and quantitative insulin sensitivity check index) for Iranian pregnant women and their newborns and (2) associations between maternal anthropometric and metabolic values and infants’ birth weights among Iranian women.Methods:Anthropometric and metabolic values of 163 singleton non-diabetic pregnant women in Tehran, Iran (2014) were collected before and during pregnancy and at delivery. Linear regression, multivariable regression, and Student t tests were used to evaluate correlations between birth weight and maternal variables.Results:Linear regression modeling suggested that maternal serum glucose (p = 0.2777) and age (p = 0.6752) were not associated with birth weight. Meanwhile, maternal weight and body mass index before pregnancy (p = 0.0006 and 0.0204, respectively), weight at delivery (p = 0.0036), maternal height (p = 0.0118), and gestational age (p = 0.0016) were positively associated with birth weight, while serum insulin (p = 0.0300) and homeostatic model assessment for insulin resistance (p = 0.0334) were negatively associated with infant’s birth weight. Using multivariate modeling, we identified severalconfounders: parity (multipara mothers delivered heavier babies compared to first-time mothers) explained as much as 24% of variation in birth weight (p = 0.005), maternal height explained 20.7% (p = 0.014), gestational age accounted for 19.7% (p = 0.027), and maternal body mass index explained 19.1% (p = 0.023) of the variation in the infant’s birth weight. Maternal serum insulin and infant’s sex were not observed to be associated with birth weight (p = 0.342 and 0.669, respectively) in the overall model.Conclusion:Overweight/obese women may experience higher incidence of delivering larger babies. Multivariable regression analyses showed that maternal body mass index and height, parity, and gestational age are associated with newborn’s birth weight.

Características antropométricas maternas y del lactante, correlacionado a la concentración proteica del calostro y leche madura: un estudio longitudinal

“…(16) Las madres antes del parto presentaron un IMC promedio de 27,19. La categoría más resaltante es el de las madres con sobrepeso (60,78%), podríamos atribuirlas al crecimiento intrauterino del bebé y a los cambios fisiológicos propios del embarazo.…”

“…Estos resultados son congruentes con otros estudios en los que también se evidencia la influencia del IMC pregestacional en el peso del recién nacido. (16) (26) La relación entre proteínas de leche madura y talla del lactante al cuarto mes, es un hallazgo del presente estudio, del cual no se ha encontrado antecedentes. Siendo el primero que describe que las proteínas de la leche materna determinarían la talla del lactante.…”

Relationship between maternal anthropometry and birth weight in a Sri Lankan cohort of term neonates

“…Many studies done in this aspect focused on most commonly used maternal anthropometric measures, such as pre-pregnancy weight, height, Body Mass Index (BMI) and Gestational weight gain, due to their significant association with intrauterine growth 2,5,[7][8][9][10] . Different degrees of associations between maternal anthropometric measures and newborn birth weight were reported in those studies [2][3][4][5][6][7]11 . Differences in relationships could be due to variations in growth potentials among different communities.…”

“…Further, it is strongly associated with the babies' risk of mortality, and health in later in life 1 . Among many other factors, maternal anthropometry plays a crucial role in determining the neonatal BW [1][2][3][4][5][6] . Many studies done in this aspect focused on most commonly used maternal anthropometric measures, such as pre-pregnancy weight, height, Body Mass Index (BMI) and Gestational weight gain, due to their significant association with intrauterine growth 2,5,[7][8][9][10] .…”

“…Among many other factors, maternal anthropometry plays a crucial role in determining the neonatal BW [1][2][3][4][5][6] . Many studies done in this aspect focused on most commonly used maternal anthropometric measures, such as pre-pregnancy weight, height, Body Mass Index (BMI) and Gestational weight gain, due to their significant association with intrauterine growth 2,5,[7][8][9][10] . Different degrees of associations between maternal anthropometric measures and newborn birth weight were reported in those studies [2][3][4][5][6][7]11 .…”