Associations Between Lipid Measures and Metabolic Syndrome, Insulin Resistance and Adiponectin  - Usefulness of Lipid Ratios in Korean Men and Women -

Kim, Heejin; Lee, Sang−Wha; Lee, Hong Soo; Shim, Kyung Won; Cho, Choo Yon; Yun, Ji Eun; Jee, Sun Ha

doi:10.1253/circj.cj-09-0571

Cited by 88 publications

(77 citation statements)

References 27 publications

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“…In our study, TG was found to be an independent predictor of incident DM in both fasting and non-fasting men and non-fasting women. Meanwhile, fasting TG is associated with HOMA-IR in European, Australian Aboriginal, Chinese and Korean individuals 32,33) . Moreover, a decrease in the effects of insulin has been shown to not only increase the TG level, but also decrease the HDLC level, resulting in an increased TG/HDL ratio 33) .…”

Section: Discussionmentioning

confidence: 99%

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Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

Fujihara

Sugawara

Heianza

et al. 2014

JAT

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Aim: The levels of lipids, especially triglycerides (TG), and obesity are associated with diabetes mellitus (DM). Although typically measured in fasting individualsUtility of TG for Predicting Diabetes tions at baseline. Moreover, we excluded 19,191 men and 35,407 women who did not participate in the 1994 survey, thereby ensuring that subjects were followed up for at least one year. A total of 39,196 men and 87,980 women were followed up annually until the diagnosis of DM or the end of 2007. A fasting state was defined as not having had a meal for at least eight hours based on a self-reported questionnaire.

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Section: Discussionmentioning

confidence: 99%

“…An impaired insulin function, consisting of insulin resistance and β-cell damage, is a characteristic feature of incident DM 16) . Insulin resistance is associated with TG 6,32) . In our study, TG was found to be an independent predictor of incident DM in both fasting and non-fasting men and non-fasting women.…”

Section: Discussionmentioning

confidence: 99%

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

Fujihara

Sugawara

Heianza

et al. 2014

JAT

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“…This is also in favor of the results of our study. 20 Er et al (2016) found triglyceride-glucose index is simple and clinically useful surrogate marker for insulin resistance in non diabetic individuals. 21 The prevalence of metabolic obesity in total study …”

Section: Discussionmentioning

confidence: 99%

Adiposity indicators lipid accumulation product and triglyceride-glucose index as alternate criteria for the diagnosis of metabolic obesity in adult

Tabassum

Rahman

Mozaffor

2018

Bangabandhu Sheikh Mujib Medical University Journal

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Obesity is a medical condition in which excess body fat has been accumulated to such an extent that it can cause a negative impact on health (World Health Organization, 2014). 1 The body mass index (BMI) is most commonly used to classify overweight and obesity. BMI is calculated by dividing a person's weight in kilogram with the square of his/her height in meter (kg/m 2 ).Recently, the concept of metabolic health status, apart from obesity, has gained much significance. 2 A number of studies have been identified that some subpopulations show metabolic profiles that portray gross deviations from the so far established relationship between BMI and metabolic disturbances. 3, 4 The theory that some non-obese adults have multiple risk factors for the metabolic disorders like obese adults, was first proposed almost 20 years back. 5 These non-obese adults are characterized by higher levels of adiposity, increased insulin resistance and are more prone to suffer from type 2 diabetes mellitus and cardiovascular disease. 6Obesity and overweight, according to BMI, do not always lead to metabolic disorders. In fact, some obese and overweight individuals are metabolically healthy, having normal insulin sensitivity, normal blood pressure, a favorable lipid profile and a lower proportion of visceral fat. 6 A number of studies have brought out the metabolically healthy and unhealthy obesity phenotypes in different BMI groups, considering the presence or absence of metabolic syndrome among the study subjects. 3, 4 Individuals are considered to have metabolic syndrome when they have at least three or more of the metabolic syndrome criteria. 7Emerging evidence suggests lipid accumulation product to be a new indicator of visceral adiposity. 8 It is a mathematical model based on the product of serum triglyceride level and waist circumference of an individual. It can identify insulin resistance as well. Since lipid accumulation product incorporates triglyceride along with waist circumference, which is another indicator of adiposity, it might be a superior marker of insulin resistance compared to the conventional biomarkers. 8 Lipid accumulation product is gender-specific and based on simple parameters. It did not originate from theoretical assumptions but from observations in a healthy, normal/overweight population. 8Lipid accumulation product takes visceral fat distribution into count. Visceral fat is more metabolically dangerous than the subcutaneous fat. 9 The subcutaneous fat depot functions as a | Original | Article | AbstractMetabolic obesity refers to the state of having metabolic syndrome irrespective of one's body mass index. This study was aimed to elucidate the lipid accumulation product and triglyceride-glucose index as simple and alternate criteria for detecting metabolic obesity in adult. The study was conducted in 200 adult (age range: 19-45 years). According to lipid accumulation product and triglyceride-glucose index, the prevalence of metabolic obesity was 54.0% and 53.5% respectively. With a cutoff value of 45.5, th...

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“…Leptin is a risk marker for myocardial infarction and hemorrhagic stroke in the population-based cohort. According to the prospective study WOSCOPS cohort on the association between leptin and cardiovascular diseases, leptin was an independent, predictive factor for the incidence of coronary artery disease during a 5-year follow-up [11,12].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

Cent Asian J Med Sci

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Objectives:The focus of our research was to determine and identify the cutoff level of leptin in Mongolian adults with metabolic syndrome (MS). Methods: This observed case-controlled study was performed with 259 adults (mean age 40.35±10.75; range 18-71 years old). A questionnaire and anthropological measurements were used for obtaining data. Fasting blood sugar, serum triglyceride, total cholesterol, HDL, adiponectin, leptin, and insulin were measured in fasting blood together with LDL and HOMA-IR calculations. Sensitivity and specificity were estimated for each leptin measurement, using MS as the outcome. These values were used to construct a receiver operating characteristic (ROC) curve. Results: Average leptin levels of the group with MS were 10.97±11.32 ng/ml and 23.86±11.32 ng/ml in males and females, respectively. The average leptin level of participants with MS was 17.23±1.59 ng/ml, which was significantly higher than the control group by 10.80±1.58. The MS exposed group had a much higher level of leptin than the control group (p<0.001). Leptin was the predictor of MS in both sexes (AUC-0.839, p<0.0001 for men and AUC-0.737, p<0.0001 for women). Conclusion: Leptin levels in the MS exposed group were higher than in the control group. Leptin may be a useful biomarker of cardiovascular risk in Mongolian adults.

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Associations Between Lipid Measures and Metabolic Syndrome, Insulin Resistance and Adiponectin - Usefulness of Lipid Ratios in Korean Men and Women -

Cited by 88 publications

References 27 publications

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

Utility of the Triglyceride Level for Predicting Incident Diabetes Mellitus According to the Fasting Status and Body Mass Index Category: The Ibaraki Prefectural Health Study

Adiposity indicators lipid accumulation product and triglyceride-glucose index as alternate criteria for the diagnosis of metabolic obesity in adult

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