Adiposity indicators lipid accumulation product and triglyceride-glucose index as alternate criteria for the diagnosis of metabolic obesity in adult

Abstract

Obesity is a medical condition in which excess body fat has been accumulated to such an extent that it can cause a negative impact on health (World Health Organization, 2014). 1 The body mass index (BMI) is most commonly used to classify overweight and obesity. BMI is calculated by dividing a person's weight in kilogram with the square of his/her height in meter (kg/m 2 ).Recently, the concept of metabolic health status, apart from obesity, has gained much significance. 2 A number of studies have been identified that some subpopulations show metabolic profiles that portray gross deviations from the so far established relationship between BMI and metabolic disturbances. 3, 4 The theory that some non-obese adults have multiple risk factors for the metabolic disorders like obese adults, was first proposed almost 20 years back. 5 These non-obese adults are characterized by higher levels of adiposity, increased insulin resistance and are more prone to suffer from type 2 diabetes mellitus and cardiovascular disease. 6Obesity and overweight, according to BMI, do not always lead to metabolic disorders. In fact, some obese and overweight individuals are metabolically healthy, having normal insulin sensitivity, normal blood pressure, a favorable lipid profile and a lower proportion of visceral fat. 6 A number of studies have brought out the metabolically healthy and unhealthy obesity phenotypes in different BMI groups, considering the presence or absence of metabolic syndrome among the study subjects. 3, 4 Individuals are considered to have metabolic syndrome when they have at least three or more of the metabolic syndrome criteria. 7Emerging evidence suggests lipid accumulation product to be a new indicator of visceral adiposity. 8 It is a mathematical model based on the product of serum triglyceride level and waist circumference of an individual. It can identify insulin resistance as well. Since lipid accumulation product incorporates triglyceride along with waist circumference, which is another indicator of adiposity, it might be a superior marker of insulin resistance compared to the conventional biomarkers. 8 Lipid accumulation product is gender-specific and based on simple parameters. It did not originate from theoretical assumptions but from observations in a healthy, normal/overweight population. 8Lipid accumulation product takes visceral fat distribution into count. Visceral fat is more metabolically dangerous than the subcutaneous fat. 9 The subcutaneous fat depot functions as a | Original | Article | AbstractMetabolic obesity refers to the state of having metabolic syndrome irrespective of one's body mass index. This study was aimed to elucidate the lipid accumulation product and triglyceride-glucose index as simple and alternate criteria for detecting metabolic obesity in adult. The study was conducted in 200 adult (age range: 19-45 years). According to lipid accumulation product and triglyceride-glucose index, the prevalence of metabolic obesity was 54.0% and 53.5% respectively. With a cutoff value of 45.5, th...

Comparison of Ten Surrogate Insulin Resistance and Obesity Markers to Identify Metabolic Syndrome in Mexican Adults

“…Studies in China [17] and Bangladesh [18] found TyG to be one of the best surrogate markers for determining MetS. However, they also found LAP and the visceral adiposity index (VAI) to be efficacious in middle-aged and elderly Chinese [18]. The results were similar to those obtained in the Korean population [19].…”

“…Some of these markers have been analyzed in Asian countries. Studies in China [17] and Bangladesh [18] found TyG to be one of the best surrogate markers for determining MetS. However, they also found LAP and the visceral adiposity index (VAI) to be efficacious in middle-aged and elderly Chinese [18].…”