Associations Between Diabetes and Clinical Markers of Benign Prostatic Hyperplasia Among Community-Dwelling Black and White Men

Sarma, Aruna V.; Burke, J. P.; Jacobson, Debra J.; McGree, Michaela E.; Sauver, Jennifer St.; Girman, Cynthia J.; Lieber, Michael M.; Herman, William H.; Macoska, Jill A.; Montie, James E.; Jacobsen, Steven J.

doi:10.2337/dc07-1148

Cited by 67 publications

(38 citation statements)

References 39 publications

(34 reference statements)

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“…Higher serum concentrations of IGF-1 and IGFBP-3 have been associated with increased risk of clinical BPH and BPH surgery. Physician-diagnosed diabetes, increased serum insulin, and elevated fasting plasma glucose have been associated with increased prostate volume and increased risks of BPH and LUTS in multiple different cohorts cumulatively incorporating tens of thousands of men [9,[14][15][16][17][18][19][20][21][22].…”

Section: Diabetesmentioning

confidence: 99%

Lifestyle factors, benign prostatic hyperplasia, and lower urinary tract symptoms

Parsons

2011

Current Opinion in Urology

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Lifestyle factors present a novel opportunity for the prevention and treatment of benign prostatic hyperplasia and lower urinary tract symptoms. Although clinical trials of lifestyle modifications have not yet been undertaken, promotion of healthy lifestyle alternatives within the context of standard benign prostatic hyperplasia and lower urinary tract symptoms treatment algorithms is potentially beneficial.

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Section: Diabetesmentioning

confidence: 99%

Lifestyle factors, benign prostatic hyperplasia, and lower urinary tract symptoms

Parsons

2011

Current Opinion in Urology

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“…However, early changes in bladder function may be more subtle. Irritative lower urinary tract symptoms and nocturia have been linked to a history of diabetes [32]. The mechanisms for these alterations are incompletely understood, and this is an area that is receiving increased research attention.…”

Section: Diabetic Voiding Dysfunctionmentioning

confidence: 99%

Urinary incontinence and voiding dysfunction in elderly men

Griebling

2008

Curr Bladder Dysfunct Rep

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Voiding disorders, including urinary incontinence (UI), are common in elderly men. The aging process is associated with anatomic and physiologic changes that may predispose older adults to urinary problems. The epidemiology of UI in older adults is different from that in younger individuals. Costs associated with UI care-in terms of economic costs, health resource utilization, and personal psychosocial costs-can be quite high. UI is one of the geriatric syndromes that can negatively infl uence physical function and quality of life in the elderly. Several clinical disorders that commonly occur in older men may have important urologic correlates, such as normal pressure hydrocephalus, Parkinson's disease, diabetes, and dementia. Nocturia is also highly prevalent in this population and may be somewhat diffi cult to treat. UI is common in nursing home residents and can be associated with declines in overall and health-related quality of life. Successful treatment can have a positive impact. Effective evaluation and management rely on a strong knowledge of the etiology and treatment options for UI in elderly men.

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“…Exercise-induced bronchoconstriction (also termed exercise-induced asthma), caused by breathing cold dry air, may contribute to physical inactivity in asthma patients, eventually increasing the risk of LUTS. Apart from physical activity, other factors associated with an increased risk of LUTS include depression [11], diabetes [12], stroke [13], and heart disease [14]. Therefore, we included these comorbidities in our adjustments.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence rates of storage and voiding symptoms were 51.3 and 25.7% respectively, in males, and 59.2 and 19.5%, respectively, in females; nocturia was the most prevalent LUTS (males, 48.6%). LUTS are associated with lifestyle risk factors (cigarette smoking [7], alcohol consumption, low-level physical activity [8], and elevated body mass index [BMI] [9]) and comorbid conditions such as metabolic syndrome [10], depression [11], diabetes [12], stroke [13], and heart diseases [14]. Although asthma and BPH both have a chronic inflammatory status [15], the relationship between these 2 conditions has been only rarely investigated, and no study has yet explored the prevalence of LUTS in asthma patients.…”

Section: Introductionmentioning

confidence: 99%

The Association between Male Asthma and Lower Urinary Tract Symptoms Evaluated by the International Prostate Symptom Score: A Population-Based Study

Han

Kim

Chung

2018

Int Arch Allergy Immunol

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Objectives: We explored the association between asthma severity and lower urinary tract symptoms (LUTS) using the International Prostate Symptom Score in a population-based study of males (aged ≥19 years) and evaluated voiding and urine storage symptoms. Methods: This was a cross-sectional study of 101,848 males, 2,544 of whom had asthma, who participated in the 2011 Korean Community Health Survey. All subjects were assessed in terms of sociodemographic data, pre-existing conditions, and the presence of LUTS. Logistic regression was used to identify risk factors for LUTS in asthmatics. Results: Urine storage symptoms (frequency, urgency, and nocturia) and voiding symptoms (straining, a weak stream, intermittency, and incomplete emptying) were significantly higher in the asthma group than in the nonasthma group (all p < 0.001). Moderate and severe LUTS were significantly more common in the asthma group (moderate, 24.3%; severe, 22.5%) than in the nonasthma group (moderate, 9.5%; severe, 2.9%). Compared to the mild LUTS group, the odds ratio (OR) for asthma was 2.21 (95% confidence interval [CI] 1.99–2.46) in the moderate LUTS group, and 3.04 (95% CI 2.64–3.51) in the severe LUTS group. In a model evaluating multiple variables, the OR for asthma in the moderate LUTS group was 1.95 (95% CI 1.74–2.16) and that in the severe LUTS group was 2.17 (95% CI 1.87–2.53). Asthma was associated with both voiding and storage symptoms. Conclusions: Male asthma was associated with moderate-to-severe LUTS. More aggressive urological diagnosis and treatment are needed for patients with asthma.

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Associations Between Diabetes and Clinical Markers of Benign Prostatic Hyperplasia Among Community-Dwelling Black and White Men

Cited by 67 publications

References 39 publications

Lifestyle factors, benign prostatic hyperplasia, and lower urinary tract symptoms

Lifestyle factors, benign prostatic hyperplasia, and lower urinary tract symptoms

Urinary incontinence and voiding dysfunction in elderly men

The Association between Male Asthma and Lower Urinary Tract Symptoms Evaluated by the International Prostate Symptom Score: A Population-Based Study

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