Associations between BODE Index and Systemic Inflammatory Biomarkers in COPD

Gaki, Eleni; Kontogianni, Konstantina; Papaioannou, Andriana Ι.; Bakakos, Petros; Gourgoulianis, Konstantinos; Κostikas, Κonstantinos; Alchanatis, Manos; Papiris, Spyridon; Loukides, Stelios

doi:10.3109/15412555.2011.619599

Cited by 29 publications

(37 citation statements)

References 32 publications

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“…27 Evaluation of Incapacity. Similar to other studies, [46][47][48] the present work reports a statistically significant decrease in submaximal exercise capacity in the COPD group compared with the non-COPD group. The 6MWD decrease of ϳ97 m is considered clinically important, since it was higher than the 6MWD 30-m minimal important difference in adults with chronic respiratory disease.…”

Section: Evaluation Of Deficiencysupporting

confidence: 81%

Incapacity, Handicap, and Oxidative Stress Markers of Male Smokers With and Without COPD

2016

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Section: Evaluation Of Deficiencysupporting

confidence: 81%

Incapacity, Handicap, and Oxidative Stress Markers of Male Smokers With and Without COPD

2016

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“…In other studies where COPD patients and controls were well matched for age, gender and BMI, the circulating leptin levels were not significantly different between stable COPD patients and healthy controls [17,24,25,30,31,32]. However, Gaki et al [33] demonstrated that leptin levels were higher in COPD patients who used inhaled corticosteroids.…”

Section: Resultsmentioning

confidence: 99%

“…As an appropriate treatment, glucocorticosteroids might be used in COPD patients. The higher leptin levels in COPD patients demonstrated by Gaki et al [33] and Creutzberg et al [53] were probably influenced by corticosteroids [54]. However, whether the administration of corticosteroids could affect serum leptin levels was still controversial [27,55,56] and is worthy of further exploration.…”

Section: Discussionmentioning

confidence: 99%

Circulating Leptin Concentrations in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

Zhou

Yuan

Zhang³

et al. 2013

Respiration

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Background: Weight loss is a clinically important risk factor indicating a poor prognosis in chronic obstructive pulmonary disease (COPD). Leptin is an important regulator of food intake and energy expenditure. Objectives: To conduct a meta-analysis to determine whether the level of leptin is related to the disease status of COPD. Methods: Studies published before December 2012 were identified by searching PubMed, Embase and the Cochrane Database. Observational studies comparing circulating leptin levels between COPD patients and healthy controls were included. Data were independently extracted by two investigators and analyzed using Stata 12.0 software. Results: Ten articles were included in the meta-analysis. Circulating leptin levels were correlated with the body mass index (BMI) as well as percent fat mass in stable COPD patients. The correlation coefficient tended to be weaker during exacerbation. A positive correlation between leptin and tumor necrosis factor (TNF)-α levels was found in COPD exacerbations, while it disappeared in patients with stable disease. Most studies indicated that circulating leptin levels in stable COPD patients were not significantly different from those in healthy controls when adjusted for gender and BMI, whilst leptin levels tended to elevate in exacerbation groups. Conclusions: The normal regulatory mechanism of leptin is maintained in stable COPD patients despite weight loss. The additional correlation between leptin and TNF-α during exacerbations may support the closer association of leptin with changes in nutritional parameters and suggests its valuable role in the evaluation of systemic inflammatory responses in COPD patients during exacerbation, which merits further study.

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“…The pathophysiology of these systemic manifestations is unclear; however, recent work on peripheral blood biomarkers suggests that there may be biomarker signatures in blood that are associated with COPD phenotypes (4). Examples of candidate biomarkers include C-reactive protein, IL-6, tumor necrosis factor-a, leptin, and adiponectin (5,6).…”

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confidence: 99%

The Association of Adiponectin with Computed Tomography Phenotypes in Chronic Obstructive Pulmonary Disease

Carolan

Kim

Williams

et al. 2013

Am J Respir Crit Care Med

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Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder associated with systemic manifestations that contribute to its morbidity and mortality. Recent work suggests that biomarker signatures in the blood may be useful in evaluating COPD phenotypes and may provide insight into the pathophysiology of systemic manifestations. Adiponectin, primarily produced by fat cells, has been implicated in the pathophysiology of emphysema. Objectives: To investigate the association of adiponectin with clinical and radiologic COPD phenotypes. Methods: Adiponectin levels were determined in 633 individuals, including 432 individuals with COPD from a cohort of former or current smokers enrolled in the COPDGene study. Univariate and multiple regression analysis were used to examine the association of adiponectin with clinical and physiologic data together with quantitative high-resolution computed tomography parameters. Measurements and Main Results: Multiple regression analysis confirmed that higher plasma adiponectin levels were independently associated with emphysema, decreasing body mass index, female sex, older age, and lower percentage change in prebronchodilator/ post-bronchodilator FEV 1 . Conclusions: The association between plasma adiponectin and computed tomography-assessed emphysema suggests a contribution of adiponectin to the development of emphysema and highlights a role for metabolic derangements in the pathophysiology of emphysema.

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Associations between BODE Index and Systemic Inflammatory Biomarkers in COPD

Cited by 29 publications

References 32 publications

Incapacity, Handicap, and Oxidative Stress Markers of Male Smokers With and Without COPD

Incapacity, Handicap, and Oxidative Stress Markers of Male Smokers With and Without COPD

Circulating Leptin Concentrations in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

The Association of Adiponectin with Computed Tomography Phenotypes in Chronic Obstructive Pulmonary Disease

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