Associations between atopic diseases and the polymorphic systems ABO, kidd, inv and red cell acid phosphatase

Brachtel, R; Walter, H.; Beck, William S.; Hilling, Maria

doi:10.1007/bf00569354

Cited by 27 publications

(21 citation statements)

References 7 publications

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“…A study conducted in Germany reported the higher incidence of blood group antigens A and B in patients with atopic diseases (atopic dermatitis, hay fever, allergic rhinitis, bronchial asthma, and acute urticaria) in comparison with controls (individuals clinically free of allergic conditions and without allergy in the family history) (9). Several studies suggest that there is an association between specific ABO blood types and some medical conditions commonly associated with NP (4-6, 10).…”

Section: Discussionmentioning

confidence: 99%

ABO and RhD Blood Groups in Nasal Polyposis

Jelavić

Marković

Klarić

et al. 2018

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to determine ABO and RhD blood group distribution in nasal polyposis (NP) patients and whether there is a specific ABO or RhD blood phenotype associated with susceptibility to or protection with respect to development of NP. Methods:The study group comprised 126 consecutive patients with chronic rhinosinusitis and bilateral NP. The control group comprised 126 healthy blood donors. All participants were from the same geographical region. Distribution of ABO and RhD phenotypes in all participants was studied.Results: There were no significant differences between patients and controls in the distribution of the A (p=0.520), B (p=0.306), AB (p=0.673), O (p=0.894), and RhD (p=0.742) phenotypes. Conclusion:According to the present results, the ABO and RhD blood group systems are not associated with development of NP.

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Section: Discussionmentioning

confidence: 99%

ABO and RhD Blood Groups in Nasal Polyposis

Jelavić

Marković

Klarić

et al. 2018

Turk Arch Otorhinolaryngol

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“…Earlier investigations of genetic markers in atopy have shown a preponderance of Km( 1 ) [4], the marker for the k light chain of immunoglobulins. In atopic patients an imbalanced IgG subclass pattern with increased IgG4 is common [9,12,18,19].…”

Section: Discussionmentioning

confidence: 99%

“…In atopy an association has been found to the allo type Km(l) for k light chains of the immunoglobulins on chromosome 2 [4], Earlier investigations did not reveal any deviation from normal as to Gm allotypes, but the G2m(n) allotype was not investigated. Re cently produced monoclonal antibodies to G2m(n) were used to investigate atopic patients, known to have the characteristic imbalanced IgG subclass pat tern with increased IgG4.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Atopy and Gm Allotypes

Oxelius

1990

Int Arch Allergy Immunol

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In 50 consecutive atopic Caucasian patients with increased IgE > 600 kU/l, the phenotypic Gm allotype constellation deviated from that to be expected, with significantly increased frequency of patients with the phenotype Gm(fnb). There was an increased frequency of the G2m(n) allotype, more frequent in patients with IgE > 1,000 kU/l, and in patients with IgG4 > 1 g/l. In patients with IgE > 1,000 kU/l, the phenotype Gm(afnb) was significantly increased and in patients with IgG4 > 1 g/l the phenotype Gm(fnb) was significantly increased. Those atopic patients with increased IgE and increased IgG4, according to earlier studies known to have the most severe forms of the disease, were thus mainly found to have the m(fnb) phenotype.

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“…One such study found statistically significant differences in the frequencies of the ABO and related secretor phenotypes in Australian adults (6) and another reported a greater incidence of A and B red blood cell phenotypes in patients with different atopical conditions compared to controls. (7) Associations between the ABO and Secretor systems and asthma have also been observed in Italian (8) and Taiwanese children (9) but not in Indian adults. (10) Despite these contradictory results observed among patients suffering from asthma, studies associating these genetic markers with allergic rhinitis are scarce.…”

Section: Introductionmentioning

confidence: 98%

Evidence of an association between the O blood group and allergic rhinitis

Falsarella¹,

Ferreira²,

Nakashima³

et al. 2011

Rev. Bras. Hematol. Hemoter.

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ObjectiveThe aim of this study was to verify if ABO phenotypes are associated with allergic rhinitis.Methods168 patients with allergic rhinitis and 168 control individuals from the same geographical region and paired by gender and age were enrolled in the study. ABO phenotypes were identified in red blood cells using the hemagglutination technique. The Fisher exact and chi-squared tests were employed to compare proportions. Statistical significance was set for an alpha error of 5% (p-value < 0.05).ResultsThe overall differences in the frequencies of the ABO phenotypes of patients and controls were marginal (χ2: 7.569; degrees of freedom (DF): 3; p-value = 0.055) however the O blood group was associated with allergic rhinitis (χ2: 5.764; DF: 1; p-value = 0.016; OR: 1.735; CI 95%: 1.127-2.673). The differences in the frequencies of the O phenotype in patients and controls were statistically different for men (χ2: 8.520; DF: 1; p-value = 0.003) but not for women (χ2: 0.6375; DF: 1; p-value = 0.4246). The A phenotype was associated with protection (OR: 0.4385; CI 95%: 0.2043-0.9415; p-value = 0.049) and the O phenotype was associated with susceptibility (OR = 2.789; CI 95%: 1.385-5.616; p-value = 0.005) to allergic rhinitis only for men.ConclusionThe O blood group phenotype is associated with allergic rhinitis in male but not in female patients.

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Associations between atopic diseases and the polymorphic systems ABO, kidd, inv and red cell acid phosphatase

Cited by 27 publications

References 7 publications

ABO and RhD Blood Groups in Nasal Polyposis

ABO and RhD Blood Groups in Nasal Polyposis

Correlation between Atopy and Gm Allotypes

Evidence of an association between the O blood group and allergic rhinitis

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