ABO and RhD Blood Groups in Nasal Polyposis

Abstract

Objective: The aim of this study was to determine ABO and RhD blood group distribution in nasal polyposis (NP) patients and whether there is a specific ABO or RhD blood phenotype associated with susceptibility to or protection with respect to development of NP. Methods:The study group comprised 126 consecutive patients with chronic rhinosinusitis and bilateral NP. The control group comprised 126 healthy blood donors. All participants were from the same geographical region. Distribution of ABO and RhD phenotypes in all participants was studied.Results: There were no significant differences between patients and controls in the distribution of the A (p=0.520), B (p=0.306), AB (p=0.673), O (p=0.894), and RhD (p=0.742) phenotypes. Conclusion:According to the present results, the ABO and RhD blood group systems are not associated with development of NP.

Association between the phenotype of the blood group system AB0 and Leukemia.

“…Similarly, more cases were reported that expected of CML in patients with blood groups B and CLL in persons with blood group 0, as reported by Wolpin [24][25][26][27]. In this regard, this investigation is added to all of those in which were found an association of the AB0 blood system with different pathologies, such as cardiovascular disease, familial hypercholesterolemia, and hepatitis B virus infection, or a worse diagnosis in diseases such as urothelial carcinoma of the gall bladder [14,[28][29][30], on contrasting our results with those of investigations that did not report an association of the AB0 system with pathologies such as nasal polyposis, endometriosis, and osteoporosis [4,[31][32][33]. The clinical importance of the systems of blood groups currently extends beyond Transfusional Medicine.…”

Association of TBX21 gene polymorphism with nasal polyposis

“…[1] The etiology of NP is multifactorial, and many theories have been proposed regarding the pathogenesis of NP, although none of them have been proven, yet. [2] The first step of the pathogenetic reaction which progresses to NP is a mucosal stimulus formed by a triggering agent (i.e., bacteria, virus, fungus, or allergen). Also, many other cytokines and inflammatory proteins are produced by the migration of inflammatory cells to the mucosa and the expression of adhesion molecules.…”