Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women

Jeon, Young Joo; Choi, Yewon; Rah, HyungChul; Kim, Su Yeoun; Choi, Dong Hee; Hee, Sun; Shin, Ji Eun; Shim, Sung Han; Lee, Woo Sik; Kim, Nam Keun

doi:10.1016/j.gene.2011.12.026

“…20,21 Recently, 4 well-known miRNA polymorphisms in premiRNA sequences (miR-146aC>G [rs2910164; chromosome 5, 159912418], miR-149T>C [rs2292832; chromosome 2, 241395503], miR-196a2T>C [rs11614913; chromosome 12, 54385599], and miR-499A>G [rs3746444; chromosome 20, 33578251]) have been studied in a variety of diseases and were found to contribute to pathogenesis. [22][23][24][25][26] According to recent data, the miR-146aG, miR-149T, miR-196a2C, and miR-499G alleles are possible genetic predisposing respectively. These miRNA targets are related to thrombosis or inflammation pathways in the circulation system.…”

mentioning

confidence: 99%

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

Jeon

¹

,

Kim

²

,

Oh

³

et al. 2013

ATVB

Self Cite

View full text Add to dashboard Cite

Objective— MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a , miR-149 , miR-196a2 , and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. Methods and Results— Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 patients with ischemic stroke, 373 patients with SBI, and 553 control subjects. The miR-146a C>G polymorphism and miR-146a G/ -149 T/ -196a2 C/ -499 G allele combination was significantly associated with ischemic stroke prevalence. For SBI prevalence, there were no statistically significant genetic markers. However, some allele combinations were associated with increased SBI incidence (C-T-C-G and G-T-T-A of miR-146a / -149 / -196a2 / -499 ). In subgroup analyses, miR-146a C>G increased stroke risk in female, normotensive, and nondiabetic groups. There were significant combined effects between microRNA polymorphisms and homocysteine/folate levels on ischemic stroke and SBI prevalence. Conclusion— The miR-146a G allele and miR-146a G/ -149 T/ -196a2 C/ -499 G allele combination were associated with ischemic stroke pathogenesis. The combined effects between microRNA polymorphisms and homocysteine/folate levels may contribute to stroke and SBI prevalence.

show abstract

“…Similarity, Parveen et al, assessed the potential of the risk of miR-196a2 polymorphism between women suffering from of unexplained RPL and normal group in the North Indian women, which was disclosed as an increased risk in allelic level in miR-196a2 T > C of RPL (19). In addition, Jeon et al, adjusted this nucleotide variation in the aborted embryones, and the findings showed the significantly different frequency of the miR-196a2 CC genotypes compared with control subjects (4). Previous findings proposed a significant role of the miRNA in the cell proliferation and differentiation in spontaneous miscarriage.…”

Section: Discussionmentioning

confidence: 99%

“…The findings suggested that the miRNAs may be required for the natural function of the conceptual process. The earlier investigation has been evaluated as significant potential roles of other miRNAs in the recurrent miscarriage (4). The contradictory of before declaring data and speculated that these molecules may be contributing to the increase of RPL phenomena, we endeavored to examine possible relationships between the miRNA SNPs miR-196a2 T > C and miR-499 A > G gene polymorphisms the risk of RPL in the Tabriz of Iranian population.…”

Section: Introductionmentioning

confidence: 99%

Association Study of Non-Coding RNA miR-499 and miR196a2 Gene Polymorphisms with the Risk of Idiopathic Recurrent Pregnancy Loss

Fazli

¹

,

Ghorbian

²

2018

View full text Add to dashboard Cite

Background: MicroRNAs (miRNAs) play significant roles in several physiological procedures such as embryo implantation. Recently, findings have indicated that aberrant miRNAs gene expression and single nucleotide polymorphism in the gene encoded miRNAs may be contributed to the pathogenesis of recurrent pregnancy loss (RPL). This investigation aimed to examine potential associations between the two precursor miRNA SNPs miR-196a2 T > C and miR-499 A > G and susceptibility to RPL. Methods: We were analyzing a total of 200 subjects, which consisted of 100 women who experienced three or more recurrent miscarriages and 100 healthy women with one child and without historical aberrations. The genotypic frequencies of two SNPs were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique to assess the association between the presence miRNA gene variant with the risk of RPL. Results: The genotypes frequency of miR-499 gene polymorphism AA/AG + GG and GG/AG + AA showed a statistically significant association with the risk of RPL (P = 0.019; OR = 2.003; 95% CI, 1.116 -3.594) and (P = 0.024; OR = 2.100; 95% CI, 1.095 -4.025), respectively. The genotypes frequency of miR-196a2 gene polymorphisms did not reveal a statistically significant difference across the two groups (P > 0.05). Conclusions: Our findings proposed that nucleotide changes in miR-499 gene encoding region may be contributed as a genetic predisposition factor to RPL, whereas the miR-196a2 gene variation cannot be a negative effect on pregnancy outcome.

show abstract

“…unc.edu/Èlin/hapstat/) was used to estimate haplotype frequencies for polymorphisms that were determined by MDR analysis to have strong synergistic effects. 30 Statistical analyses were performed with GraphPad Prism 4.0 (GraphPad Software Inc, San Diego, CA) and StatsDirect software version 2.4.4 (StatsDirect Ltd, Altrincham, UK). Statistical significance was set at P G 0.05.…”

Section: Discussionmentioning

confidence: 99%

“…24<28 In addition, miRNA polymorphisms have been linked to a genetic predisposition to recurrent pregnancy loss in Chinese and Korean populations through disruption of miRNA production. 29,30 Previously, we identified an association between POI risk and SNPs in miR-146a and miR-196a2 (rs2910164 and rs11614913). 27 Interestingly, these two miRNA SNPs were also shown to be associated with breast cancer risk in cancer susceptibility studies.…”

mentioning

confidence: 99%

Association of breast cancer–related microRNA polymorphisms with idiopathic primary ovarian insufficiency

Rah¹,

Hee

²

,

Kim

³

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women

Cited by 71 publications

References 45 publications

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

Association of the miR-146a , miR-149 , miR-196a2 , and miR-499 Polymorphisms With Ischemic Stroke and Silent Brain Infarction Risk

Association Study of Non-Coding RNA miR-499 and miR196a2 Gene Polymorphisms with the Risk of Idiopathic Recurrent Pregnancy Loss

Association of breast cancer–related microRNA polymorphisms with idiopathic primary ovarian insufficiency

Contact Info

Product

Resources

About