Association of breast cancer–related microRNA polymorphisms with idiopathic primary ovarian insufficiency

Rah, HyungChul; Hee, Sun; Kim, Young Ran; Lee, Woo Sik; Ko, Jung Jae; Kim, Nam Keun

doi:10.1097/gme.0000000000000325

Cited by 17 publications

(11 citation statements)

References 67 publications

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“…Accumulating evidence has illustrated that dysfunction of miRNAs leads to follicle atresia through regulating dysregulation of granulose cell proliferation, progression, and apoptosis, which is closely associated with female fecundity (Reza et al, 2019). Likewise, susceptible polymorphisms and abnormal expression profiles of miRNAs have been reported in POI (Chen, Xie, Liu, & Shi, 2015; Cho et al, 2017; Dang et al, 2015; Pan et al, 2016; Rah, Kim et al, 2015; Rah, Jeon, Lee et al, 2013; Rah, Jeon, Shim et al, 2013; Yang et al, 2012; Zhang et al, 2013; Zhou et al, 2011). Recently, our group has identified miR‐379‐5p as the first functional miRNA in granulosa cells (GCs) from biochemical POI (bPOI) women, which adversely affected proliferation and DNA repair function of GCs (Dang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

Zhang

Dang

Liu

et al. 2020

Journal Cellular Physiology

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Distinct microRNA (miRNA) profiles have been reported in premature ovarian insufficiency (POI), but their functional relevance in POI is not yet clearly stated. In this study, aberrant expressions of miR‐127‐5p and high mobility group box 2 (HMGB2) were observed by microarrays in granulosa cells (GCs) from biochemical POI (bPOI) women and further confirmed by a quantitative reverse‐transcription polymerase chain reaction. Immortalized human granulosa cell line and mouse primary ovarian GCs were used for functional validation. Orthotopic mouse model was established to examine the role of miR‐127‐5p in vivo. Finally, the expression of miR‐127‐5p was measured in the plasma of bPOI women. The receiver operating characteristic curve analysis was performed to determine the indicative role of miR‐127‐5p for ovarian reserve. Results showed the upregulation of miR‐127‐5p was identified in GCs from bPOI patients. It inhibited GCs proliferation and impaired DNA damage repair capacity through targeting HMGB2, which was significantly downregulated in GCs from the same cohort of cases. miR‐127‐5p was confirmed to attenuate DNA repair capability via HMGB2 in mouse ovary in vivo. Intriguingly, the upexpression of miR‐127‐5p was also detected in plasma of bPOI individuals, suggesting that miR‐127‐5p could be a promising indicator for bPOI. Taken together, our results discovered the deleterious effects of miR‐127‐5p on GCs function and its predictive value in POI process. The target gene HMGB2 could be considered as a new candidate for POI. This study highlights the importance of DNA repair capacity for ovarian function and sheds light on the epigenetic mechanism in the pathogenicity of POI.

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Section: Introductionmentioning

confidence: 99%

MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

Zhang

Dang

Liu

et al. 2020

Journal Cellular Physiology

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“…Another Korean study suggested that breast cancer-related miRNA polymorphisms, including miR-27a A > G, miR-423C > A, and miR-608G > C, are associated with increased idiopathic risk of POI via interaction among the miR-27aG, miR-423A, and miR-608G variants [60]. However, the study should be further substantiated owing to the small sample size and low statistical power.…”

Section: Introductionmentioning

confidence: 99%

Role of microRNAs in premature ovarian insufficiency

Guo

Sun

Lai

2017

Reprod Biol Endocrinol

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Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction. MicroRNAs (miRNAs) are a class of endogenous noncoding RNAs (ncRNAs) that can mediate post-translational silencing of the genes involved in the regulation of proliferation, differentiation, apoptosis, development, tumorigenesis, and hematopoiesis. Recently, the regulatory functions of miRNAs in the development of POI have been the topic of intensive research. The present review addresses the association of miRNAs’ machinery genes (Dicer, Drosha, and XPO5) with POI and the miRNA expression profiles in the plasma of patients with POI. In addition, several specific miRNAs (miR-23a, miR-27a, miR-22-3p, miR-146a, miR-196a, miR-290-295, miR-423, and miR-608) related to POI are also examined in order to highlight the issues that deserve further investigation. A thorough understanding of the exact regulatory roles of miRNAs is imperative to gain novel insights into the etiology of idiopathic POI and offer new research directions in the field.

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“…Hsa-MIR423 rs6505162 C OA might also be associated with a significantly increased risk of esophageal squamous cell carcinoma in patients who smoke (Yin et al 2013). Additionally, MIR423 COA has been associated with an increased risk of primary ovarian insufficiency (Rah et al 2015). These previous studies imply that MIR423 rs6505162 has the potential to become a biomarker for the diagnosis of many clinical diseases.…”

Section: Discussionmentioning

confidence: 85%

The polymorphism of rs6505162 in the MIR423 coding region and recurrent pregnancy loss

Su¹,

Hu²,

Liu³

et al. 2015

Reproduction

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Although the relationship between polymorphisms in microRNAs (miRNAs) and recurrent pregnancy loss (RPL) has been studied, there is very little data available in the literature. In the present study, we scanned 55 potentially functional polymorphisms in the miRNA coding region in Chinese women with unexplained RPL (URPL; no. 2011-10). The rs6505162 COA in the MIR423 coding region was found to be significantly associated with the occurrence of human URPL. The rare A allele contributed to an increase in the expression of mature MIR423. C to A substitution in the polymorphism rs6505162 in pre-MIR423 repressed cell proliferation and migratory capacity. Further investigations showed that MIR423 could inversely regulate the expression of proliferation-associated 2 group 4 (PA2G4) by binding the 3 0 -UTR of PA2G4. Dual-luciferase assay indicated that the A allele in the polymorphism rs6505162 could more effectively suppress the expression of PA2G4 than the C allele could. Collectively, the present data suggest that rs6505162 COA in pre-MIR423 may contribute to the genetic predisposition to RPL by disrupting the production of mature MIR423 and its target gene, which consequently interferes with MIR423 functioning.Reproduction (2015) 150 65-76

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Association of breast cancer–related microRNA polymorphisms with idiopathic primary ovarian insufficiency

Cited by 17 publications

References 67 publications

MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

Role of microRNAs in premature ovarian insufficiency

The polymorphism of rs6505162 in the MIR423 coding region and recurrent pregnancy loss

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