Association study of HNF1A polymorphisms with metabolic syndrome in the Moroccan population

Morjane, Imane; Kéfi, Rym; Charoute, Hicham; yaagoubi, Fouzia Lakbakbi el; Hechmi, Meriem; Saı̈le, Rachid; Abdelhak, Sonia; Barakat, Abdelhamid

doi:10.1016/j.dsx.2017.07.005

Cited by 17 publications

(20 citation statements)

References 34 publications

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“…Previous studies showed that AFP promoter mutations in the distal HNF1-binding region and the proximal HNF1-binding region play important roles in regulating AFP expression [12,13]. Currently, HNF1A gene variants are associated with maturity onset diabetes of the young (MODY) [14,15], Creactive protein (CRP) levels [16][17][18], gamma-glutamyl transferase (GGT) levels [19,20], total cholesterol (TC) levels [21], pancreatic cancer [22], coronary artery disease [21,23], and metabolic syndrome (MS) [24]. The most common variants in HNF1A are rs1169288 (A/C, Ile27Leu), rs2464196 (G/A, Ser487Asn), and rs1169310 (C/T), which have been reported to be associated with the CRP level, coronary artery disease, and diabetic retinopathy [17,18,25,26].…”

Section: Introductionmentioning

confidence: 99%

Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients

Shao

Mei-lin

et al. 2019

Disease Markers

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Although alpha-fetoprotein (AFP) is a widely used tumor marker in hepatocellular carcinoma (HCC), 40% of newly diagnosed patients do not have an elevated AFP level. Research has revealed that mutations in the HNF1A binding site of the AFP gene promoter cause significantly elevated serum AFP levels in patients with hereditary persistence of AFP. This study investigated the relationship between HNF1A genetic variants and serum AFP levels. We examined the association between the HNF1A-rs1169288 (A/C), rs2464196 (G/A), and rs1169310 (C/T) polymorphisms and AFP levels in a healthy Chinese population (n=1010) and HCC patients (n=185). Single nucleotide polymorphisms were genotyped by the amplification refractory mutation system combined with TaqMan probe in real-time PCR. The serum AFP concentrations were measured using the Architect i2000 immunochemistry analyzer. In healthy individuals, serum AFP levels were significantly lower with the rs2464196-AA and rs1169310-TT genotypes. Similar significant differences were observed in HCC patients. Moreover, in HCC patients, the distribution frequencies of rs2464196-AA+AG and rs1169310-TT+TC among those with AFP≤20 ng/ml or ≤400 ng/ml were significantly lower than those in patients with AFP>20 ng/ml or >400 ng/ml. Among all subjects, those carrying the HNF1A-rs2464196-A or rs1169310-T allele tended to have low levels of AFP. However, the HNF1A-rs1169288 polymorphism showed no significant association with the serum AFP level. These findings provide new insight into the genetic determinants of serum AFP level and can aid the differential diagnosis of HCC patients with low serum AFP.

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Section: Introductionmentioning

confidence: 99%

Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients

Shao

Mei-lin

et al. 2019

Disease Markers

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“…, and LCAT [rs5923 (4886C/T)]. Similar association was, respectively, observed in Tunisian population with LRPAPI (rs762861), FTO (rs9939609), and ACE (Insdel, I/D) gene polymorphisms (Elouej et al, 2016c;Mehri et al, 2010) and Moroccan population with ApOE (e2/e3/e4) and HNFIA (rs575396) (Bennouar et al, 2004;Morjane et al, 2017).…”

Section: Association Of Genetic Markers With Tcmentioning

confidence: 53%

“…After screening titles and abstracts, we found 2923 records to be irrelevant and excluded them. We assessed full texts of the remaining 180 articles for eligibility, of which 22 were finally included (Abd El-Aziz et al, 2011Abdel Ghany et al, 2017;Abdel-Hamed et al, 2017;Bennouar et al, 2004;Boghdady et al, 2016;Ellman et al, 2015;Elouej et al, 2016aElouej et al, , 2016bElouej et al, , 2016cEngwa et al, 2018;Fekih et al, 2014;Hooper et al, 2007;Kefi et al, 2017;Khella et al, 2017;Kodogo et al, 2016;Masemola et al, 2007;Mehri et al, 2010;Morjane et al, 2017;Sediri et al, 2011;Sellami et al, 2018) and 158 were excluded with reasons as indicated in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

“…Populations, genetic assessment, and outcomes Seventeen of the 22 included studies (72.3%) were conducted in Northern Africa (7 in Egypt, 8 in Tunisia and 2 in Morocco) (Abd El-Aziz et al, 2011Abdel Ghany et al, 2017;Abdel-Hamed et al, 2017;Bennouar et al, 2004;Boghdady et al, 2016;Elouej et al, 2016aElouej et al, , 2016bElouej et al, , 2016cFekih et al, 2014;Kefi et al, 2017;Khella et al, 2017;Mehri et al, 2010;Morjane et al, 2017;Sediri et al, 2011;Sellami et al, 2018), whereas only 5 were performed in sub-Saharan African populations (1 in Zimbabweans, 1 in Nigerians, and 3 in South Africans) (Ellman et al, 2015;Engwa et al, 2018;Hooper et al, 2007;Kodogo et al, 2016;Masemola et al, 2007). Most studies were conducted among patients with coronary artery disease, diabetes mellitus, or metabolic syndrome.…”

Section: Literature Searchmentioning

confidence: 99%

“…On the contrary, an increased level of HDL-C was associated with FTO (rs8054077), ACE Ins16del (I/D) gene polymorphisms in Tunisian population (Elouej et al, 2016c;Mehri et al, 2010), ApoB [4154 (G>A)] gene polymorphism in Zimbabweans population (Kodogo et al, 2016), ApoE [Apo E polymorphisms (n2)] gene polymorphism in South African population (Masemola et al, 2007), IL-1A (rs3783553) gene polymorphism in Egyptian population (Abdel Ghany et al, 2017), ABCC8 [(C49620T) (rs1799854)] gene polymorphism in Nigerian population (Engwa et al, 2018) and HNF1A [rs735396 (T>C)] gene polymorphism in Moroccan population (Morjane et al, 2017). All the other gene polymorphisms investigated did not seem to have an effect on HDL-C levels ( Table 2).…”

Section: Association Of Genetic Markers With Tcmentioning

confidence: 99%

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Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Noubiap

Mato

Guewo-Fokeng

et al. 2018

OMICS: A Journal of Integrative Biology

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Identification of genetic/genomic factors contributing to dyslipidemia is of great interest to prevention and reduction of the onset and burden of cardiovascular diseases in Africa. This systematic review summarizes available data on genetic variants associated with dyslipidemia in populations within Africa. A PubMed and EMBASE database search was conducted to identify all studies published until June 2018 on genetic susceptibility to dyslipidemia in African-based populations, excluding familial hypercholesterolemia. All studies on genetic predispositions of dyslipidemia and respecting the preestablished inclusion criteria were included in this systematic review. Because of high heterogeneity, the data were summarized narratively. Twenty-two studies investigated mostly the targeted genetic variants. A total of 51 polymorphisms in 28 susceptibility genes to dyslipidemia have been associated with a particular trait in the African populations, and through variable effects. Most polymorphisms investigated in Northern Africa seemed to have consistent effects on increasing the level of low-density lipoprotein cholesterol (LDL-C), total cholesterol, and triglycerides in patients with diabetes, myocardial infarction, coronary artery disease, and metabolic syndrome. By contrast, only Ser447Ter and C49620T variants were associated with increased LDL-C in sub-Saharan Africa. Despite few studies available in this context in the literature, certain genetic variants were consistently associated with dyslipidemia especially in Northern Africa as highlighted in this analysis. Further data, particularly from genome-wide association studies, would help establish an African-specific reference for genetic susceptibility markers of dyslipidemia.

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The Metabolic Syndrome: Prevalence, Associated Risk Factors and Health Complications in Obese Subjects in Northern Morocco

Hamjane

Benyahya

Mechita

et al. 2019

Advances in Intelligent Systems and Computing

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Association study of HNF1A polymorphisms with metabolic syndrome in the Moroccan population

Cited by 17 publications

References 34 publications

Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients

Association of Common Variants in HNF1A Gene with Serum AFP Level in Healthy Chinese Individuals and HCC Patients

Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

The Metabolic Syndrome: Prevalence, Associated Risk Factors and Health Complications in Obese Subjects in Northern Morocco

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