Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Noubiap, Jean Jacques; Mato, E.P. Mofo; Guewo-Fokeng, Magellan; Kazé, Arnaud D.; Boulenouar, Houssam; Wonkam, Ambroise

doi:10.1089/omi.2018.0158

“…Dyslipidemia has received little attention in West Africa. The majority of dyslipidemia studies are based on populations of European decent with limited studies based on African populations [ 31 ]. Among these African population-based studies, the majority are Northern African populations and Southern African populations.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Diawara,

Coulibaly,

Kone

et al. 2024

JDM

0

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Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (P = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]).

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“…Dyslipidemia has received little attention in West Africa. The majority of dyslipidemia studies are based on populations of European decent with limited studies based on African populations [30]. Among these African population-based studies, the majority are Northern African populations and Southern African populations.…”

Section: Discussionmentioning

confidence: 99%

“…There are few studies that focus on these characteristics in Africa, studies are needed to complement those studies in developed countries. Within Africa, genetic associations differ by geographic location [30]. A natural progression for epidemiological studies for diabetic dyslipidemia lies in epigenetics.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Diawara¹,

Coulibaly²,

Koné³

et al. 2023

Preprint

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View full text Add to dashboard Cite

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be routinely captured through standard surveillance activities. This study aimed to characterize the prevalence and demographic profile of dyslipidemia in T2D patients in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and blood tests. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (p = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (p = .013 and p = .036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (p = .029 and p = .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

show abstract

“…There are few investigations that focus on these characteristics in Africa, studies are needed to complement data collected in developed countries. Within Africa, genetic associations differ by geographic location [31]. A natural progression for epidemiological studies for diabetic dyslipidemia lies in epigenetics.…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in adults with type 2 diabetes in a rural community in Ganadougou, Mali: A cross-sectional study

Diawara

¹

,

Coulibaly

²

,

Fofana

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We per-formed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (p = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (p = .013 and p = .036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (p = .029 and p = .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concom-itant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

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Genetic Determinants of Dyslipidemia in African-Based Populations: A Systematic Review

Cited by 5 publications

References 52 publications

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study

Dyslipidemia in adults with type 2 diabetes in a rural community in Ganadougou, Mali: A cross-sectional study

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