Association study of c.910A>G and c.1686C>G polymorphisms in XRCC1 gene with risk of hepatocellular carcinoma in the Chinese population

Abstract

ABSTRACT. XRCC1 (human X-ray repair complementing defective repair in Chinese hamster cell 1) gene is considered a potentially important gene influencing the risk of hepatocellular carcinoma (HCC). Our analyses detected two allelic variants of XRCC1, c.910A>G and c.1686C>G. We aimed to investigate whether these polymorphisms influence the risk of HCC. The association between the XRCC1 polymorphisms and the risk of HCC was analyzed in 719 patients and 662 controls by polymerase chain reaction-restriction fragment length polymorphism. Our data suggested that the genotypes and alleles of c.910A>G and c.1686C>G polymorphisms were statistically associated with the risk of HCC. For c.910A>G, the GG genotype was associated with increased risk of developing HCC compared with the AA wild XRCC1 associated with liver cancer genotype (OR = 1.95, 95%CI = 1.40-2.70, P < 0.0001). For c.1686C>G, the risk of HCC was significantly higher for the GG genotype compared with the CC wild genotype (OR = 1.89, 95%CI = 1.375-2.599, P < 0.0001). Significant differences in the risk of HCC were also found with other genetic models for these two SNPs. The G allele of both c.910A>G and c.1686C>G may contribute to the risk of HCC (G versus A: OR = 1.40, 95%CI = 1.20-1.64, P < 0.0001 and G versus C: OR = 1.38, 95%CI = 1.19-1.61, P < 0.0001, respectively). Our findings suggest that the c.910A>G and c.1686C>G polymorphisms of XRCC1 are associated with the risk of HCC in the Chinese population.

XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

“…Previous studies showed significant association between HCC and different SNPs in XRCC1 gene. Xia et al, (2014) noted that the genotypes and alleles distribution of XRCC1 variants c.910A>G and c.1686C>G were statistically associated with the risk of HCC. reported that c.1804C>A genetic polymorphism of XRCC1 may influence the risk of HCC (Liu et al, 2014).…”

Association between XRCC1 polymorphisms and laryngeal cancer susceptibility in a Chinese sample population

“…So far, several studies have reported on the association between XRCC1 polymorphisms and development of several types of cancers, including non-small cell lung cancer, gastric cancer, cervical cancer, hepatocellular carcinoma, pancreatic cancer, ovarian cancer, colorectal cancer, and thyroid cancer (Liu et al, 2012;Abdel-Fatah et al, 2013;Feng et al, 2014;Wang and Ai, 2014;Xia et al, 2014;Cătană et al, 2015;Han et al, 2015;Huang et al, 2015;Xu et al, 2015;Zhao and Chen, 2015;Ghosh et al, 2016). Liu et al (2015) observed a significant relationship between the XRCC1 Arg399Gln polymorphism and risk of cervical cancer in a meta-analysis comprising 2051 cervical cancer patients and 2919 control subjects.…”