XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Naguib, Mary; Helwa, Mohamed A; Soliman, Mervat M.; Abdel‐Samiee, Mohamed; Eljaky, Ashraf; Hammam, Osama; Zaghla, Hassan; Abdelsameea, Eman

doi:10.31557/apjcp.2020.21.4.1031

Cited by 10 publications

(9 citation statements)

References 20 publications

(18 reference statements)

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“…Thus, to develop an effective personalized treatment, the detection of SNPs is especially important for the susceptibility of cervical cancer. We have chosen Apurinic/apyrimidinic (AP) endonuclease and X-ray repair cross-complementing 1 (XRCC1) which are two key DNA repair genes involved in the base excision repair (BER) pathway (Naguib et al, 2020;Abbas et al, 2019). The APE-148 the protein encoded by the APE1 gene (present on chromosome 14q11.2-q12) creates a nick in the phosphodiester backbone of the AP site (at the 5'-) and leaves a 3'-hydroxyl group and a 5'-deoxyribose phosphate group flanking the nucleotide gap for the initiation of the BER (Bardia et al, 2012) XRCC1 which acts as a central scaffolding protein and interacts directly with enzymatic factors such as ligase III, DNA polymerase β, and poly (ADP-ribose) polymerase to expedite efficient single strands break and evoke BER by binding to the damaged DNA (Konathala et al, 2016).…”

Section: Research Articlementioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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Backgrounds: Cervical cancer (CC) is one of the leading cause of death in women worldwide, HPV infection is the major risk factor in the disease development, 0and however other risk factor such as chemical carcinogens, genetic susceptibility and altered immune system are also a cause of the disease progression. In the light of the above statement we studied the base excision repair pathway (BER). Methods: We identified and studied the association of Single Nucleotide polymorphisms in the DNA repair genes of XRCC1 ( Arg194Trp, Arg399G ,) and APE-1Asp/148Glu to the susceptibility of cervical cancer (CC) in North Indian population. In our study of cases (n=102). Controls (n=109) were recruited from among women without cervical abnormalities. Genotypes were determined by PCR-CTPP method, Taking DNA from peripheral blood in a case control study. Results: A positive association was observed between the polymorphisms of XRCC1 genes, that is, in codons 194 (P=0.03, odds ratio (OR) =2.39, 95% confidence interval (CI)=5.2–1.1), 280 (P=0.01, OR=4.1, 95% CI=11.5–1.3) and 399 (P=0.01, OR=3.4, 95% CI=8.6–1.3) while APE-1 genotype GG (p=0.03,odds ratio(OR)=0.2,95% confidence interval (CI)=0.97-0.004) we observed a statistically significant protective role in developing cervical cancer. Conclusion: Our results suggested that, XRCC1 gene is an important candidate gene for susceptibility to cervical cancer. Although the sample size was small, the present study indicate a statistical association between cervical cancer and XRCC1 SNPs . Future studies are needed that may provide a better understanding of the association between gene polymorphism and cervical carcinoma risk.

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Section: Research Articlementioning

confidence: 99%

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Charles

Raza

Sharma

et al. 2020

Asian Pac J Cancer Prev

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“…XRCC1 has three common SNPs, namely exon 6 (C>T) produces Arginine/Tryptophan substitution at codon 194, exon 9 (G>A) changes amino acids Arginine / Histidine at codon 280 and exon 10 (G>A) changes amino acids Arginine/Glutamine at codon 399. This polymorphism was reported to increase the risk of hepatocellular carcinoma in the Egyptian population (Surniyantoro et al, 2019;Naguib et al, 2020).…”

Section: Introductionmentioning

confidence: 95%

Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia

Surniyantoro

Fahlevi

Savitri

et al. 2021

Nusantara Science and Technology Proceedings

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One of the important DNA repair pathways is base excision repair (BER), which plays in the human body to maintain DNA integrity, prevent cancer and DNA damage. X-ray repair cross-complementing group 1 (XRCC1) is the most important DNA repair protein in base excision repair (BER) pathways and has been reported to have a relationship with the risk of developing various cancers. The study was purposed to assess the genetic polymorphism of XRCC1 exon 6 and 10 as a risk factor for thyroid cancer. A total of 90 participants were enrolled in this study, consisted of 30 thyroid cancer patients as a case group and 60 noncancer patients as a control group. Examination of XRCC1 genotypes was carried out by using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method and statistical analysis using a Chi-square test. In this study, we reported the frequency of XRCC1 genetic polymorphism was not significantly different between cancer patients and control groups both in exon 6 and 10, and we predict that these polymorphisms were not a risk factor for thyroid cancer (P-value>0.05). In conclusion, both mutant variants of XRCC1 exon 6 and 10 are not risk factors for thyroid cancer. In further studies, it is necessary to assess genetic polymorphisms in populations with controlled non-genetic factors, such as diet, lifestyle, and environmental factors.

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“…The main variant alleles of XRCC1 gene are Arg399Gln (rs25487) and Arg194Trp (rs1799782). Recently, the survival association of XRCC1 SNPs and XRCC1 protein expression have been reported in various human malignant tumors such as thyroid cancer ( Liu and Xue, 2020 ), lung cancer ( Schneider et al, 2008 ), breast cancer ( Sanjari Moghaddam et al, 2016 ), gallbladder cancer ( Wu et al, 2020 ), and hepatocellular carcinoma ( Naguib et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Survival association of XRCC1 for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis

Yang

Zhou²,

Chen³

et al. 2023

Front. Genet.

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Background: Epidemiologic studies have demonstrated that X-ray repair cross-complementary group 1 (XRCC1) is one of the susceptibility factors in head and neck squamous cell carcinoma (HNSCC) patients. However, its clinical prognostic impact remains controversial. Thus, a meta-analysis was performed to clarify the association between XRCC1 and the survival outcomes in HNSCC patients.Methods: Following the Preferred Reporting Items or Systematic Reviews Meta Analyses (PRISMA) 2020 guidelines, literature searches were systematically performed in PubMed, EMBASE, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure (CNKI) databases with manual retrieval. Hazard ratios (HRs) and 95% confidence intervals (CIs) were collected to estimate the correlation between XRCC1 and the survival outcomes of HNSCC patients.Results: Ten studies including 1995 HNSCC patients who satisfied the inclusion and exclusion criteria were included in this meta-analysis. Pooled analysis indicated that XRCC1 Arg399Gln and XRCC1 high protein expression were significantly correlated with poor overall survival with HR of 1.31 (95% CIs: 1.03-1.66, p = 0.027) and 2.32 (95% CIs: 1.55-3.48 p = 0.000) in HNSCC patients. In addition, our results demonstrated that XRCC1 was significantly associated with poor progression-free survival (HR = 1.42, 95% CIs: 1.15-1.75, p = 0.001) in HNSCC patients.ConclusionThis meta-analysis demonstrated that XRCC1 Arg399Gln and XRCC1 high protein expression increase the risk of poor survival for HNSCC patients. XRCC1 is a potential therapeutic target for HNSCC.

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XRCC1 Gene Polymorphism Increases the Risk of Hepatocellular Carcinoma in Egyptian Population

Abstract: repair systems are settled to process DNA damage and maintain genomic integrity (Abbotts et al., 2014). Among these, the X-ray repair cross-complementing group1 (XRCC1) which is responsible for repair of oxidative DNA damage and single-strand breaks (London, 2015).

Cited by 10 publications

References 20 publications

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Association of DNA Repair Genes XRCC1 and APE-1 with the Risk of Cervical Cancer in North Indian population

Association of XRCC1 genetic polymorphism with the risk of thyroid cancer in Indonesia

Survival association of XRCC1 for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis

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