Association study of AGO1 and AGO2 genes polymorphisms with recurrent pregnancy loss

Kim, Young Ran; Ryu, Chang Soo; Kim, Jung Oh; An, Hee Jung; Cho, Sung Hwan; Ahn, Eun Hee; Kim, Ji Hyang; Lee, Woo Sik; Kim, Nam Keun

doi:10.1038/s41598-019-52073-0

Cited by 12 publications

(8 citation statements)

References 48 publications

(51 reference statements)

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“…More than 65 genetic variants in 45 genes were identified that could be considered as risk factors for iRPL (Table 1). 13–59 The time frame of the sample is not mentioned in the studies because it does not involve a variable marker. Epigenetic factors, mainly microRNAs (miRNAs), that could also be considered as risk factors are compiled in Table 2 60–64 .…”

Section: Resultsmentioning

confidence: 99%

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Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

Kaur

Chhabra³

et al. 2023

Intl J Gynecology & Obste

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BackgroundRecurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples.ObjectiveTo investigate the relationship between variants in the candidate susceptibility genes and epigenetic factors to identify risk factors for idiopathic recurrent pregnancy loss (iRPL).Search StrategyA systematic literature search was performed using PubMed, Google Scholar, ScienceDirect, and Scopus databases. Insilico analysis was carried out using ShinyGO and STRING software.Selection CriteriaResearch papers examining the association between variations in genetic and epigenetic factors and iRPL.Data Collection and AnalysisData were independently extracted by two authors.Main ResultsIn total, 83 research papers were finally selected for the present study. Among all the genes involved in the pathogenesis of recurrent pregnancy loss, polymorphisms in IL superfamily genes, VEGF, ESR, and MTHFR were the most investigated.ConclusionPolymorphisms in angiogenesis, immune tolerance, and thrombophilia pathway genes, which occur independently or synergistically, may lead to various complications during fetal development. Identification of multi‐allele risk variants and epigenetic factors in women will be helpful in the identification of high‐risk pregnancies.Prospero Registration NumberProspero CRD42021287315.

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Section: Resultsmentioning

confidence: 99%

“…Polymorphisms in DICER , DROSHA 49,51 ; miR‐125 52 ; miR‐27a , miR‐449b 54 ; miR‐423 55 ; AGO ‐1 59 ; and MTRR 30 have also been correlated with the condition. However, no association was found for DICER (rs3742330); DROSHA (rs10719); XPO5 (rs11077) 51 ; RAN (rs14035) 109,110 ; and lncRNA CCAT2 (rs3843549) 58 .…”

Section: Resultsmentioning

confidence: 99%

Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

Kaur

Chhabra³

et al. 2023

Intl J Gynecology & Obste

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“…4e), validating the binding affinity of miR-5194 and LINC01063 in melanoma cells. According to previous literature, AGO2 has been identified as a cytoplasmic protein within the RNA-induced silencing complex, and can bind with miRNAs [39,40]. Thereby, we carried out an RIP assay, noticing that LINC01063 and miR-5194 coexisted in the same RISC complex (Fig.…”

Section: Resultsmentioning

confidence: 99%

LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression

Nie

et al. 2022

Melanoma Research

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Melanoma is one of the most aggressive skin cancers and a major cause of cancer-linked deaths worldwide. As the morbidity and mortality of melanoma are increasing, it is necessary to elucidate the potential mechanism influencing melanoma progression. Tumor tissues and adjacent normal tissues (5 cm away from tumors) from 22 melanoma patients at the I–II stage and 39 patients at the III–VI stage were acquired. The expression of LINC01063 in melanoma was estimated by quantitative PCR. Functional assays were employed to investigate the function of LINC01063 in melanoma. Mechanism assays were adopted to explore the mechanism of LINC01063. LINC01063 knockdown impeded melanoma cell proliferation, migration, invasion, and epithelial–mesenchymal transition as well as melanoma tumor growth. Mechanistically, LINC01063 acted as an miR-5194 sponge to upregulate SOX12 expression. Finally, LINC01063 was tested to facilitate the malignant behaviors of melanoma cells via targeting miR-5194/SOX12. LINC01063 was significantly upregulated in melanoma. Specifically, LINC01063 displayed a higher level in patients at an advanced stage or with metastasis than those at an early stage or without metastasis. Our study revealed the oncogenic effects of LINC01063 on melanoma cell/tumor growth and its molecular mechanism involving miR-5194/SOX12, which might support LINC01063 to be the potential prognostic or therapeutic biomarker against melanoma.

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“…As Ago2 works as one of RNA-induced silencing complex (RISC) components, 22 an Ago2 protein within the RISC complex could bind to an miRNA, for which the binding affinities of miRNA-Ago2 complexes have been confirmed. 23,24 Hence, Ago2-RIP assays were performed, and we found that circKIAA0368, miR-6838-5p, and HOXA10 mRNA all existed in the RISC (Figure 4E). The binding sites of miR-6838-5p on circKIAA0368 and HOXA10 mRNA were predicted by starBase (Figure 4F).…”

Section: Circkiaa0368 Sponges Mir-6838-5p To Upregulate Hoxa10 In Npc...mentioning

confidence: 93%

CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma

Chen

Gong

et al. 2022

Am J Rhinol�Allergy

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Background: Nasopharyngeal carcinoma (NPC) represents a head and neck cancer caused by cancerization of nasal epithelial cells. HOXA10 has been identified to promote proliferation and invasion of NPC cells, but its regulatory mechanism has not been well discussed. Published research work has also pointed out that circular RNAs (circRNAs) could regulate mRNAs to affect NPC tumorigenesis and development. Aim: To explore the roles of HOXA10 and its specific regulatory mechanism regarding circRNAs in NPC. Methods: Reverse transcription polymerase chain reaction and western blot were applied to test gene expression. Functional assays were used to evaluate changes in NPC cell phenotypes. Mechanism assays were done to verify RNA-RNA or RNA-protein interaction. Results: HOXA10 was highly expressed in NPC tissues and cell lines. Moreover, HOXA10 knockdown could restrict NPC cell proliferation, invasion, migration, and epithelial–mesenchymal transition. CircKIAA0368 was upregulated in NPC cells and could elevate HOXA10 expression by sponging miR-6838-5p. Furthermore, circKIAA0368 was unveiled to competitively bind to p300/CREB-binding protein-associated factor (PCAF) to repress acetylation and degradation of HOXA10 protein. Conclusion: CircKIAA0368 upregulates HOXA10 expression via miR-6838-5p and PCAF, consequently promoting NPCcell and tumor growth.

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Association study of AGO1 and AGO2 genes polymorphisms with recurrent pregnancy loss

Cited by 12 publications

References 48 publications

Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

LINC01063 functions as an oncogene in melanoma through regulation of miR-5194-mediated SOX12 expression

CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma

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