Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population

Beikzadeh, Behnaz; Angaji, Seyed Abdolhamid; Abolhasani, Maryam

doi:10.1186/s12881-020-01014-0

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…In the early stages of PCa, symptoms are rarely appearing. There may be no symptoms at the time of diagnosis even in the advanced states [2]. Blood in the urine and semen [3], recurrent pain in the affected area [4], difficulty in urinating [5], sudden or frequent urination [6], unexplained weight loss [7], pain in the pelvis [8], thighs and back [9], pain or abnormal symptoms in the penis [10], poor urination, and bone pain [11] are signs of cancer progression.…”

Section: Introductionmentioning

confidence: 99%

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2022

Journal of Bioinformatics and Comparative Genomics

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After lung cancer, prostate cancer has the highest mortality rate. Early and accurate diagnosis of this heterogeneous cancer promises more effective treatment. At present biopsy is the only definitive method of diagnosing the disease. Many gene loci are associated with increased susceptibility to this cancer. Here, the relationship between tumor necrosis factor alpha (TNF-α) gene variants and glucuronidation pathway gene variants with increased risk of prostate cancer in a population of Iranian men has been investigated. Materials and methods:Blood samples were collected from 360 men including 120 healthy, 120 with benign prostate hyperplasia (BPH), and 120 patients with prostate cancer (PCa). DNA was extracted and tested for each variant with specific primers and PCR based methods. Data were analyzed using agarose and polyacrylamide gel electrophoresis, SPSS software, SNP Stats and Student's t-test.Results: UGT2B17 and UGT2B15 polymorphisms were associated with BPH in comparison to the control group (P value = <0.0001 and P value = 0.007). The only significant association in the cancer group was between G Score and UGT2B15, so that 90% of patients with PCa and G score less than or equal to 6, had GG genotype (0.01). Other variants had no significant relationship with the cause of the disease. Ins Del G haplotype was more common in BPH compared to the control group (P value = 0.011).

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Section: Introductionmentioning

confidence: 99%

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2022

Journal of Bioinformatics and Comparative Genomics

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Association study between rs1571801 and rs16260 with prostate adenocarcinoma predisposition in Iranian population

Rahimi

Angaji

Karimi

et al. 2023

Egypt J Med Hum Genet

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Background Prostatic adenocarcinoma is the most frequent malignancy among elderly men after lung cancer, which has the second incidence and the fourth mortality rate in the Iranian population. The primary objective of this study was to investigate how single-nucleotide polymorphisms of the CDH1 gene (rs16260) and DAB2IP (rs1571801) are associated with the risk of prostate cancer through a multi-stage approach. Results In the first stage of the study (58 men), we compared the genotype frequency of polymorphisms rs16260 and rs1571801 in the case group to the control group to determine significant polymorphisms (P value < 0.4). No statistically significant difference was shown between the genotype frequency of rs1571801 in the case and control groups. Thus, rs1571801 polymorphism was eliminated at this stage, and only rs16260 polymorphism evaluated in the next stage. In the second stage, statistical analysis showed a significant difference between genotype frequency of rs16260 (P value = 0.037) in all participants. The effect of rs16260 on prostate cancer was not modified by age or PSA levels. Only the Gleason Score = 7 reveals a significant difference between the risk allele (A) and the allele (C) (rs16260). Conclusions According to the results of this study, rs16260 is associated with prostate cancer predisposition and might be used as a potential biomarker in prostate cancer. It should be noted that these results need to be confirmed in a larger population.

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Investigating the Association of rs4962416 and rs6465657 with Prostate Adenocarcinoma in the Iranian Population

Hemmati,

Angaji,

Beikzadeh

et al. 2023

CPPM

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Background: Prostate cancer is one of the most commonly diagnosed malignancies in the developed world. Despite other risk factors like age, diet, environment and the pathogenesis of prostate cancer, recent advances in molecular genetics suggest that genetic inheritance plays an important role in prostate cancer. Objective: We attempted to analyze the association of SNPs rs4962416 and rs6465657 in the development of prostate cancer. A better understanding of the association of SNPs in prostate cancer susceptibility may improve risk prediction, improve precision mapping, and provide new insights into the underlying pathophysiology of prostate cancer. To date, no one has investigated these two SNPs in the Iranian populations, and according to the heterogeneity that exists, SNPs in communities should be examined separately. Methods: This case-control study includes 82 people with prostate adenocarcinoma as cases and 96 people with benign prostatic hyperplasia (BPH) as controls. Genotyping of each participant was done by TETRA ARMS-PCR method and for statistical analysis chi-squared, Fisher’s exact logistic regression was used to find the SNPs associated with prostate cancer. Result: The frequency of the polymorphisms rs4962416 and rs6465657 in the prostate adenocarcinoma group was evaluated compared to the BPH control group (p-value < 0.05%) to choose the meaningful SNP. For rs4962416, we didn’t find any meaningful association with prostatic cancer (P=0.402) but for rs6465657 there was a significant difference between genotype frequency (P=0.001). Conclusion: rs6465657 polymorphism which is associated with prostate cancer, can be chosen as a biomarker for this cancer and there should be more investigation on this SNP as these results need to be confirmed in a larger population.

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Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population

Cited by 4 publications

References 45 publications

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Untitled

Association study between rs1571801 and rs16260 with prostate adenocarcinoma predisposition in Iranian population

Investigating the Association of rs4962416 and rs6465657 with Prostate Adenocarcinoma in the Iranian Population

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