Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung

Fukui, Hitoshi; Horie, Masanori; Endoh, Shigehisa; Kato, Haruhisa; Fujita, Katsuhide; Nishio, Keiko; Komaba, Lilian Kaede; Maru, Junko; Miyauhi, Arisa; Nakamura, Ayako; Kinugasa, Shinichi; Yoshida, Yasukazu; Hagihara, Yoshihisa; Iwahashi, Hitoshi

doi:10.1016/j.cbi.2012.04.007

Cited by 170 publications

(126 citation statements)

References 37 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…Although the antioxidantrelated proteins that reported by Fukui et al (including lipid peroxide, heme oxygenase-1 and alpha-tocopherol) 8) were not identi ed in our study, the other similar antioxidant proteins, peroxiredoxin-6 and -1, were observed with up-regulation in BALF of ZnO NPs exposed rats (Table 1). According to the above observations, these ndings support those reported previously, 1,6) namely that inhalation or instillation of ZnO NPs predominantly results in lung in ammation and systemic toxicity.…”

Section: Resultscontrasting

confidence: 58%

“…1,6) For example, Roy et al showed the ZnO NPs provided an adjuvant e ect and induced 2 responses in mice exposed to the allergen ovalbumin 7) ; Fukui et al reported the intratracheal instillation of ZnO NPs can induce an increase in antioxidants, including lipid peroxide, heme oxygenase-1 and alpha-tocopherol, in the lungs of exposed rat. 8) Moreover, a previous study found that ZnO NPs were highest potency regarding induction of acute lung in ammation in murine inhalation model. 9) Despite the above observations, the DOI: 10.5702/massspectrometry.S0066…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Proteomic Analysis of Rat Bronchoalveolar Lavage Fluid after Exposure to Zinc Oxide Nanoparticles

et al. 2017

View full text Add to dashboard Cite

Zinc oxide nanoparticles (ZnO NPs) are one of the most widely used nanomaterials in consumer products and industrial applications. As a result of all these uses, this has raised concerns regarding their potential toxicity. We previously found that candidate markers of idiopathic pulmonary brosis and lung cancer were signi cantly up-regulated in rat bronchoalveolar lavage uid (BALF) following exposure to ZnO NPs by using a liquid chromatography (LC)-based proteomic approach. To achieve comprehensive protein identication analysis, we conducted the two-dimensional gel electrophosis (2-DE)-based proteomic work ow to analyze the di erences in BALF proteins from rats that had been exposed to a high dose of 35 nm ZnO NPs. A total of 31 di erentially expressed protein spots were excised from the gels and analyzed by nanoLCtandem mass spectrometry (MS/MS). Gene ontology (GO) annotation of these proteins showed that most of the di erentially expressed proteins were involved in response to stimulus and in ammatory response processes. Moreover, pulmonary surfactant-associated protein D and gelsolin, biomarkers of idiopathic pulmonary brosis, were signi cantly up-regulated in rat BALF a er ZnO NPs exposure (2.42-and 2.84-fold, respectively). e results obtained from this present study could provide a complementary consequence with our previous study and contribute to a better understanding of the molecular mechanisms involved in ZnO NP-induced lung disorders.

show abstract

Section: Resultscontrasting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Comparative Proteomic Analysis of Rat Bronchoalveolar Lavage Fluid after Exposure to Zinc Oxide Nanoparticles

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Some nanoparticles, especially metallic and metallic oxide nanoparticles, are prone to the release of ions inside or outside of organisms and cells. 48,49 When the released ions are more toxic, it complicates the evaluation of nanoparticle toxicity. This is especially true for some quantum dots, most of which are made of toxic heavy metals.…”

Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

“…75 ZnO nanoparticles induced oxidative stress in the lungs of rats, as indicated by increased lipid peroxide, HO-1, and alpha-tocopherol levels. 48 Because ZnO nanoparticles can release zinc ions (Zn…”

Section: Respiratory Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Perturbation of physiological systems by nanoparticles

et al. 2014

View full text Add to dashboard Cite

Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

show abstract