Association of vitamin D receptor gene 3′‐variants with Hashimoto's thyroiditis in the Croatian population

Štefanić, Mario; Papić, Stana; Suver, Mirjana; Glavaš‐Obrovac, Ljubica; Karner, Ivan

doi:10.1111/j.1744-313x.2008.00748.x

Cited by 55 publications

(46 citation statements)

References 35 publications

(51 reference statements)

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“…Polymorphisms of the VDR gene were related to HT, as mentioned previously (35). Moreover, polymorphisms of the CYP27B1 hydroxylase gene catalyzing the conversion of 25 hydroxyvitamin D 3 (25(OH)D) to its active form were also associated with HT (69).…”

Section: The Role Of Vitamin D Deficiencymentioning

confidence: 64%

“…Several genes are known to be associated with the disease occurrence, progression, and severity. Among them are genes coding for human leukocyte antigen (HLA-DR), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), CD40, protein tyrosine phosphatase 22 (PTPN22), interleukin 2 receptor, alpha (IL2RA), and vitamin D receptor (VDR) (17,34,35). The only thyroid-specific gene associated with HT is the gene for Tg (17).…”

Section: Susceptibility and Candidate Genesmentioning

confidence: 99%

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MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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Thyroid disorders, especially Hashimoto's thyroiditis (HT), and polycystic ovary syndrome (PCOS) are closely associated, based on a number of studies showing a significantly higher prevalence of HT in women with PCOS than in controls. However, the mechanisms of this association are not as clear. Certainly, genetic susceptibility contributes an important part to the development of HT and PCOS. However, a common genetic background has not yet been established. Polymorphisms of the PCOS-related gene for fibrillin 3 (FBN3) could be involved in the pathogenesis of HT and PCOS. Fibrillins influence the activity of transforming growth factor beta (TGFb). Multifunctional TGFb is also a key regulator of immune tolerance by stimulating regulatory T cells (Tregs), which are known to inhibit excessive immune response. With lower TGFb and Treg levels, the autoimmune processes, well known in HT and assumed in PCOS, might develop. In fact, lower levels of TGFb1 were found in HT as well as in PCOS women carrying allele 8 of D19S884 in the FBN3 gene. Additionally, vitamin D deficiency was shown to decrease Tregs. Finally, high estrogen-to-progesterone ratio owing to anovulatory cycles in PCOS women could enhance the immune response. Harmful metabolic and reproductive effects were shown to be more pronounced in women with HT and PCOS when compared with women with HT alone or with controls. In conclusion, HT and PCOS are associated not only with respect to their prevalence, but also with regard to etiology and clinical consequences. However, a possible crosstalk of this association is yet to be elucidated.

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Section: The Role Of Vitamin D Deficiencymentioning

confidence: 64%

Section: Susceptibility and Candidate Genesmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Gaberšček

Zaletel

Schwetz

et al. 2015

European Journal of Endocrinology

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“…Horst-Sikorska Vitamin D levels in autoimmune thyroid diseases S Kivity et al 245 et al 47 linked VDR polymorphism to thyroid autoimmunity susceptibility by demonstrating a correlation between F allele carriers of the VDR-FokI polymorphism and Graves' disease. Stefanic et al 48 reported an association between VDR-common haplotypic variants and Hashimoto's thyroiditis. In addition, several studies demonstrated genetic polymorphism of the vitamin D-binding protein among Polish 49 and Japanese 50 patients with AITDs, whereas the CYP27B1 hydroxylase polymorphism was found to predispose to Hashimoto's thyroiditis and Graves' disease in German subjects.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and autoimmune thyroid diseases

et al. 2011

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The role of vitamin D as an immune modulator has been emphasized in recent years, and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus. Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. While VDR gene polymorphism was found to associate with autoimmune thyroid diseases (AITDs), few studies examined levels of vitamin D in these patients and those that did yielded conflicting results. We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls. Serum vitamin D (25-OH) levels were measured in 50 patients with AITDs, 42 patients with non-AITDs and 98 healthy subjects, utilizing the LIAISON chemiluminescence immunoassay (DiaSorin, Saluggia, Italy). Vitamin D deficiency was designated at levels lower than 10 ng/ml. Antithyroid antibodies, thyroid functions and demographic parameters were evaluated in all patients. The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals (72% versus 30.6%; P,0.001), as well as in patients with Hashimoto's thyroiditis compared to patients with non-AITDs (79% versus 52%; P,0.05). Vitamin D deficiency also correlated to the presence of antithyroid antibodies (P50.01) and abnormal thyroid function tests (P50.059). Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests, suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation.

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“…The significant association of VDR polymorphism with AITD has also indicated a potential role of vitamin D in the pathogenesis of AITD (22)(23)(24). Activated vitamin D modulates autoimmune reactions by regulating T lymphocytes to inhibit both the production and activity of cytokines (5).…”

Section: Discussionmentioning

confidence: 99%

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

Choi

Kim

et al. 2014

Thyroid

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Background: Low serum vitamin D levels have been associated with several autoimmune diseases, but their association with thyroid autoimmunity is unclear. We evaluated the association of serum vitamin D levels with the prevalence of autoimmune thyroid disease (AITD). Methods: Our cross-sectional study included subjects who underwent routine health checkups, which included assays of serum 25-hydroxy vitamin D3 [25(OH)D3] and anti-thyroid peroxidase antibody (TPO-Ab), as well as thyroid ultrasonography (US) between 2008 and 2012 at the Asan Medical Center. We defined AITD according to the levels of TPO-Ab and US findings. Results: A total of 6685 subjects (58% male; 42% female) were enrolled for this study. Overall prevalence of TPO-Ab positivity and both TPO-Ab/US positivity were 10.1% (6.3% male; 15.3% female) and 5.4% (2.3% male; 9.7% female) respectively. In female subjects, mean serum 25(OH)D3 levels were significantly lower in the TPO-Ab(+) (22.0 vs. 23.5 ng/mL, p = 0.030) and TPO-Ab(+)/US(+) groups (21.6 vs. 23.4 ng/mL, p = 0.027) compared with the control group, respectively. According to the levels of serum 25(OH)D3, the prevalence of TPO-Ab positivity (21.2%, 15.5%, and 12.6% in deficient, insufficient, and sufficient group, respectively; p = 0.001) and both TPO-Ab and US positivity (14.7%, 9.9%, and 7.1% in deficient, insufficient, and sufficient group, respectively; p < 0.001) decreased in female subjects. Interestingly, this pattern was significant only in pre-menopausal women ( p = 0.003 and p < 0.001; respectively), but not in postmenopausal women. Multivariate analysis indicated that the adjusted odds ratios (

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Association of vitamin D receptor gene 3′‐variants with Hashimoto's thyroiditis in the Croatian population

Cited by 55 publications

References 35 publications

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

MECHANISMS IN ENDOCRINOLOGY: Thyroid and polycystic ovary syndrome

Vitamin D and autoimmune thyroid diseases

Low Levels of Serum Vitamin D3 Are Associated with Autoimmune Thyroid Disease in Pre-Menopausal Women

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