Association of vitamin D receptor gene with anthropometric measures in Komi ethnic group

Abstract

The relationship between the vitamin D receptor gene (VDR) variants with serum 25 OHD3 con centration, body height (BH), body weight (BW), and body composition were examined in the Komi ethnic group. The FF genotype was associated with higher BW (p = 0.002) and lower bone mass (BM, p = 0.06) in comparison to the Ff genotype carriers. The BB genotype carriers were characterized by lower BL compared to those with Bb genotype (p = 0.037); BM was lower among those having bb rather than Bb variants (p = 0.025). No differences in the 25 OHD3 content were revealed. The results are consistent with the data obtained for populations from North Western Europe and opposite to those reported for tropical and sub tropical Caucasians, as well as for non Caucasians groups.

Untitled

“…Благоприятным в плане регуляции костного метаболизма является носительство аллеля T*BsmI . Гетерозиготность TC*BsmI ассоциирована с повышенным содержанием костной ткани у юношей и девушек коми [Kozlov et al, 2014]. В выборках молодых взрослых северных регионов РФ носители аллеля *T отличаются от гомозигот CC*BsmI более развитым костным компонентом состава тела .…”

Anthropological and ecological specificity of polymorphism in genes related to bone tissue metabolism (as exemplified by the Shors people)

“…Âûáîðêà øîðöåâ õàðàêòåðèçóåòñÿ î÷åíü âûñîêèì íîñèòåëüñòâîì àëëåëÿ C*Fok1 (66,2%) è ãåíîòèïîâ CC*Fok1 è CT*Fok1 (òàáë. 1, 2), çíà÷èìî ïðåâîñõîäÿ îáñëåäîâàííûõ ðàíåå êîìè è óðîaeåíöåâ Åâðîïåéñêîé ÷àñòè ÐÔ [Kozlov et al, 2014;Kozlov, Vershubskaya, Negasheva, 2017].…”

“…Èìåþòñÿ òàêaeå ñâåäåíèÿ î âëèÿíèè íà ìåòàáîëèçì êîñòíîé òêàíè ïîëèìîðôèçìà ãåíà VDR BsmI (rs1544410).  ñåâåðíûõ åâðîïåîèäíûõ ãðóïïàõ (ðóññêèå, êîìè) íîñèòåëüñòâî ãîìîçèãîòíîãî âàðèàíòà AA*BsmI àññîöèèðîâàíî ñî ñíèaeåíèåì ýôôåêòèâíîñòè àáñîðáöèè êàëüöèÿ ïî ñðàâíåíèþ ñ ãîìîçèãîòàìè *GG è îñîáåííî ãåòåðîçèãîòàìè *GA [Kozlov et al, 2014;Kozlov, Vershubskaya, Negasheva, 2017]. Ýòè íàáëþäåíèÿ ñîãëàñóþòñÿ ñ äàííûìè, ïîëó÷åííûìè â äðóãèõ âûáîðêàõ Ñåâåðíîé Åâðîïû [Dawson-Hughes et al 1995;Ferrara et al, 2002;Grundberg et al, 2004].…”