Association of vitamin D deficiency with acute lower respiratory tract infections in newborns

Dinlen, Nurdan; Zencıroğlu, Ayşegül; Beken, Serdar; Dursun, Arzu; Díllí, Dílek; Okumuş, Nurullah

doi:10.3109/14767058.2015.1023710

Cited by 46 publications

(47 citation statements)

References 15 publications

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“…From 547 records retrieved by our search, 34 articles published between 2008 and 2017 were finally included (Figure ). Articles are based on 26 separate study populations, including 25 longitudinal birth cohorts and one case‐control study, from 16 different countries (latitude ranging from 55ºN to 31ºS) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…Fourteen single studies assessed the association of prenatal 25(OH)D levels with the occurrence of RTIs in the offspring from birth to 36 months of age . Results of the meta‐analysis including available data showed an inverse association between prenatal vitamin D levels and risk of RTIs in offspring.…”

Section: Resultsmentioning

confidence: 99%

“…Ten studies assessed prenatal vitamin D status in maternal plasma or serum collected during pregnancy; one of them did it early in pregnancy (first trimester), 30 six in mid pregnancy (second trimester), 33,43,44,50,52,53 seven in late pregnancy (third trimester), 23,26,31,36,41,45,54 and one study measured vitamin D in all trimesters. 37 Eighteen studies measured vitamin D levels at birth in cord blood samples, 24,25,[27][28][29]32,34,35,[38][39][40]42,[46][47][48][49]55,56 and six studies measured vitamin D at both time points (pregnancy and birth). 36,50-54…”

Section: Re Sultsmentioning

confidence: 99%

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Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Pacheco-Gonzalez

García‐Marcos

Morales

2018

Pediatric Allergy Immunology

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Re Sultsmentioning

confidence: 99%

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Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Pacheco-Gonzalez

García‐Marcos

Morales

2018

Pediatric Allergy Immunology

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“…Dinlen ve ark. 'nın (20) akut alt solunum yolu enfeksiyonu olan term bebeklere yönelik yapmış oldukları bir çalışmada ise, 60 bebeğin 43'ünde 25 (OH) D seviyesi ortalama 9,5 ng/ mL iken, kontrol grubunda ise 15,5 ng/mL olarak bulunmuştur. Türkiye'den yapılan bu çalışmada, solunum yolu enfeksiyonu insidansının serum 25(OH)D seviyesi 10 ng/ml'den düşük olduğunda önemli ölçüde arttığı belirlenmiştir.…”

Section: Discussionunclassified

Association of Vitamin D Deficiency with Postnatal Respiratory Distress in Newborns

Say¹,

Öncel²,

Uraş³

2019

BUCH

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GİRİŞYenidoğanların yaklaşık %1'inde solunum sıkıntısı görülmekte ve bunların da %4,0 ile %5,7 kadarını yenidoğanın geçici takipnesi (YGT) kalanını da mekon-yum aspirasyon sendromu, pnömoni, sepsis, pnömotoraks gibi diğer nedenler oluşturmaktadır. Term bebeklerde solunum sıkıntısı risk faktörleri arasında; sezaryen doğum, zamanından önce doğum, koriyoamnionit, erkek cinsiyet, sepsis, düşük apgar, diyabe-ÖZ Amaç: Yenidoğanın geçici takipnesi (YGT), yaşamın ilk üç gününde düzelen, erken neonatal dönemde solunum sıkıntısının en yaygın nedenlerinden biridir. Çalışmanın amacı, serum 25 hidroksi vitamin D (25(OH)D) seviyesinin YGT ve YGT dışı solununum sıkıntısı nedenleri üzerine etkisini araştırmaktır. Yöntem: Bu çalışma Zekai Tahir Burak Kadın Sağlığı ve Hastalıkları Hastanesi, yenidoğan yoğun bakım ünitesi'nde prospektif, vaka-kontrol olarak planlandı. Çalışma grubu 36 gestasyonel haftadan büyük ve doğumdan hemen sonra solunum sıkıntısı gelişen 58 hastayı kapsamaktadır. Hastaların doğumdan hemen sonra serum 25(OH)D vitamini düzeyleri ölçüldü ve klinik, laboratuvar, radyolojik bulguları ile değerlendirilerek tanıları konuldu. Bulgular: Çalışma popülâsyonunda toplam 58 (34 erkek, 24 kız) yenidoğan vardı. Solunum sıkıntısı olan 36 hastadan 24 (%66)'ünde YGT, 12 (%34)'inde ise YGT dışı (neonatal pnömoni, pnömotoraks ve mekonyum aspirasyon sendromu) tespit edilmiştir. 31 (%53.4) yenidoğanın serum 25(OH)D seviyeleri ≤5 ng/mL (grup 1), 17 olgunun (%29.3) 25(OH)D seviyeleri 5-15 ng/mL arasında (grup 2), 10 olgunun (% 17.2) 25(OH)D seviyeleri > 15 ng/ mL idi (grup 3). Sonuç: Sonuç olarak, bebeklerde serum D vitamini yetersizliğinin YGT ve YGT dışı solunum sıkıntısı nedenleri için risk oluşturmadığı görüldü. 25(OH)D vitamini düzeyinin doğum sonrası dönemde solunum sıkıntısı ile ilişkisi olup olmadığını kanıtlamak için iyi tasarlanmış yeni çalışmalara ihtiyaç vardır. Anahtar kelimeler: Solunum sıkıntısı, yenidoğan, 25 (OH) D vitamini eksikliği ABSTRACT Objective: Transient tachypnea of newborn (TTN) is one of the most prevalent cause of respiratory distress which resolves within the first three days of life. The aim of this study was to investigate the effects of serum 25 hydroxy vitamin D (25 (OH) D) levels on the causes of TTN and non-TTN.Methods: This case-control study was conducted in neonatal intensive care unit of the Zekai Tahir Burak Maternity Teaching Hospital in Turkey. We enrolled 58 neonates with gestational age of ≥36 weeks who developed respiratory distress soon after birth. Serum 25 (OH) D levels were measured immediately after birth of the neonate and clinical, laboratory and radiological findings were evaluated and diagnosed. Results: The study population included a total of 58 (34 boys, 24 girls) newborns . Among the 36 patients with respiratory distress, 24 (66%) of them had TTN, 12 (34%) of them had non-TTN respiratory distress (neonatal pneumonia, pneumothorax and meconium aspiration syndrome). Of these infants, 31 (53.4%) had cord blood 25 (OH) D levels ≤5 ng/mL (Group 1), 17 (29.3%) had 25 (OH) D levels...

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“…In addition, 25(OH)D levels of the mothers of the ill infants were also found to be lower than those of controls. Thus, they suggest that vitamin D supplementation during pregnancy and after birth may enhance the respiratory health of newborns [79].…”

Section: Evidencementioning

confidence: 99%

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

2019

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Purpose Respiratory tract infections (RTIs) are a major cause of illness worldwide and the most common cause of hospitalization for pneumonia and bronchiolitis. These two diseases are the leading causes of morbidity and mortality among children under 5 years of age. Vitamin D is believed to have immunomodulatory effects on the innate and adaptive immune systems by modulating the expression of antimicrobial peptides, like cathelicidin, in response to both viral and bacterial stimuli. The aim of this review is to summarize the more recently published data with regard to potential associations of 25-hydroxyvitamin D [25(OH)D] with infectious respiratory tract diseases of childhood and the possible health benefits from vitamin D supplementation. Methods The literature search was conducted by using the PubMed, Scopus, and Google Scholar databases, with the following keywords: vitamin D, respiratory tract infection, tuberculosis, influenza, infancy, and childhood. Results Several studies have identified links between inadequate 25(OH)D concentrations and the development of upper or lower respiratory tract infections in infants and young children. Some of them also suggest that intervention with vitamin D supplements could decrease both child morbidity and mortality from such causes. Conclusions Most studies agree in that decreased vitamin D concentrations are prevalent among most infants and children with RTIs. Also, normal to high-serum 25(OH)D appears to have some beneficial influence on the incidence and severity of some, but not all, types of these infections. However, studies with vitamin D supplementation revealed conflicting results as to whether supplementation may be of benefit, and at what doses.

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Association of vitamin D deficiency with acute lower respiratory tract infections in newborns

Abstract: Lower blood 25(OH)D levels might be associated with increased risk of ALRTI in term newborn babies. Appropriate vitamin D supplementation during pregnancy and early childhood may enhance newborns' respiratory health.

Cited by 46 publications

References 15 publications

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Association of Vitamin D Deficiency with Postnatal Respiratory Distress in Newborns

The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood

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