Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta‐analysis of observational studies

Pacheco-Gonzalez, Rosa; García‐Marcos, Luis; Morales, Eva

doi:10.1111/pai.12876

Cited by 55 publications

(51 citation statements)

References 66 publications

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“…HN001 is not present in breastmilk and so direct infant supplementation is necessary to prevent infant eczema . A systematic review and meta‐analysis indicates that the intake of vitamin D during pregnancy, as measured from 25‐hydroxyvitamin D levels, is associated with a reduction in the offspring's respiratory tract infections but there is no supporting evidence on a beneficial effect on asthma or allergies . The airway microbiota composition in children is different in healthy, asthmatic, and remission groups .…”

Section: Prediction and Prevention Of Allergic Diseasementioning

confidence: 99%

“…53 A systematic review and meta-analysis indicates that the intake of vitamin D during pregnancy, as measured from 25-hydroxyvitamin D levels, is associated with a reduction in the offspring's respiratory tract infections but there is no supporting evidence on a beneficial effect on asthma or allergies. 54 The airway microbiota composition in children is different in healthy, asthmatic, and remission groups. 55 The severity of bronchial hyperresponsiveness is associated with the presence of specific bacteria, upregulation of inflammatory genes, and lack of anti-inflammatory prostaglandin E2 genes in the airway microbiome of asthmatic children.…”

Section: Pred Ic Ti On and Pre Venti On Of Allerg I C D Is E A S Ementioning

confidence: 99%

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Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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Section: Prediction and Prevention Of Allergic Diseasementioning

confidence: 99%

Section: Pred Ic Ti On and Pre Venti On Of Allerg I C D Is E A S Ementioning

confidence: 99%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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“…Another meta-analysis based on 12 prospective studies suggested even a more complex association, in which a U-shaped relationship between maternal 25(OH)D levels and risk of asthma was described [49]. A more recent study meta-analyzing the results from 14 observational studies found no association between prenatal vitamin D concentrations and risk of asthma during childhood (Pacheco-Gonzalez et al submitted [94]). Due to these controversial results, intervention studies are essential to clarify such associations.…”

Section: Prenatal Vitamin D Status and Asthma Riskmentioning

confidence: 99%

Maternal and Foetal Health Implications of Vitamin D Status during Pregnancy

Larqué

Morales

Leis³

et al. 2018

Ann Nutr Metab

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Background: To what extent does the circulating 25-hydroxyvitamin D (25[OH]D) concentration help to meet the physiological needs of humans is an ongoing subject of debate. Remaining unexposed to the sun to reduce melanoma cancer risk, current lifestyle with less out door activities, and increasing obesity rates, which in turn increases the storage of vitamin D in the adipose tissue, are presumably factors that contribute to the substantial upsurge in the prevalence of vitamin D deficiency in humans. Since evidence is lacking regarding the appropriate cut-off points to define vitamin D status during pregnancy, references used to establish the intake recommendations and vitamin D content of prenatal vitamin supplements are quite conservative. Summary: The foetus depends fully on maternal 25(OH)D supply. 25(OH)D readily crosses the placenta and it is activated into 1,25(OH)₂D by foetal kidneys. Moreover, 1,25(OH)₂D can also be synthesized within the placenta to regulate placental metabolism. The importance of vitamin D during pregnancy for maintaining maternal calcium homeostasis and therefore for foetal bone development is well recognized; major discussions are in progress regarding the potential maternal detrimental effects on pregnancy outcomes, foetal development, and the long-term health of children. Interventional studies have also evaluated the effect of vitamin D for reduction on preterm birth and asthma programming. Key Messages: Clinically, by understanding the effects of vitamin D on perinatal outcomes, we could individualize antenatal counselling regarding vitamin D supplementation to ensure vitamin D repletion without increasing the risk of foetal hypercalcemia.

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“…However, no such association was observed with other common allergens of early childhood, including foods. Vitamin D might intervene in the pathogenesis of allergy even before birth in early childhood respiratory diseases; Morales et al have reviewed the literature on this topic and did not find any association. Readers will find in previous issues other interesting articles related to vitamin D and allergy …”

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confidence: 99%