Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study

Nachankar, Amit; Kotwal, Narendra; Upreti, Vimal; Verma, Vishesh; Kumar, K.V.S. Hari

doi:10.1007/s13300-018-0508-z

Cited by 15 publications

(17 citation statements)

References 28 publications

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“…Same direction was observed for mean of FBS , while ameliorate 25(OH)D levels (sufficient group) in women with GDM normalizes FBS (8) . Our study agrees with Amit et al 2018 as he showed an equal prevalence of 25(OH)D defeciency in women with and without GDM (25) . Different observations have been presented in Zuhur et al 2013 which exhibited that GDM is linked with only severe 25(OH)D defeciency but the exposure of sun the differently , the population of study , types of diet , measurement and clarify of 25(OH) D deficiency.…”

Section: Discussionsupporting

confidence: 93%

The Level of Nesfatin -1, Calcium and Vitamin D in Women with Gestational Diabetes Versus Control

Hanan M Chiad,

Shatha M. J.AL-Khateeb,

Israa Hamid

2021

Indian Journal of Forensic Medicine & Toxicology

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Objective:This study was designed to investigate serum level nesfatin-1 and determine the association of nesfatin-1, calcium level and 25-hydroxy vitamin D (25(OH )D) level in women with gestational diabetes mellitus (GDM) versus controls Methods: A88 pregnant women at 24-28 weeks gestation were included in this study .Forty four women diagnosed with gestational diabetes and 44 women without gestational diabetes both groups were matched in age and body mass index . Then we classify each group depended on 25(OH) D status (sufficient, insufficient and deficient). nesfatin-1 and vitamin D levels were analyzed using ELISA (enzyme link immunosorbent assay) a cut off value for serum calcium were assessed using colorimetric method, cut off value were used according to manufacture instruction and the a comparison was done between above parameters. Furthermore, insufficient and deficient 25(OH)D gestational diabetes group had significantly higher fasting blood sugar compared to matched control group . Conclusion:Nesfatin-1 levels, 25(OH)D and calcium were not differ between the two groups statistically.

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Section: Discussionsupporting

confidence: 93%

The Level of Nesfatin -1, Calcium and Vitamin D in Women with Gestational Diabetes Versus Control

Hanan M Chiad,

Shatha M. J.AL-Khateeb,

Israa Hamid

2021

Indian Journal of Forensic Medicine & Toxicology

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“…Increased serum concentrations of PTH were found in diabetics (14). Nachakar et al found that increased PTH was associated with decreased insulin sensitivity, β-cell function and GDM during pregnancy, regardless of the underlying 25OHD level (37). In the present study PTH levels were not different in all groups.…”

Section: Discussionsupporting

confidence: 45%

Gestasyonel Di̇yabetes Melli̇tus İle D Vi̇tami̇ni̇, Kalsi̇toni̇n Ve Parathormon İli̇şki̇si̇

Gürsoy

Halis²,

Çopur³

et al. 2021

Ankara Eğitim Ve Araştırma Hastanesi Tıp Dergisi

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AIM:There is growing evidence that Vitamin D (vitD) has an important role in glucose metabolism. Although there are some observational studies reporting lower levels of 25 hydroxy vitamin D in pregnant women with gestational diabetes mellitus (GDM) compared to normal pregnant women, the other calcium metabolism hormones calcitonin (Cal) and parathyroid hormone (PTH) have not been fully researched in GDM. The aim of this study was to investigate the effects of vitD, Cal and PTH in GDM. MATERIAL AND METHODS:A total of 100 pregnant women whose ages and body mass indices were similar, fifty with normal glucose tolerance (NGT) and the other fifty with GDM, were included in the study. Their demographic and anthropometric parameters, vitD, active vitD, Cal and PTH levels in the summer season were screened retrospectively. The pregnant women with GDM were classified according to the age, parity, being veiled, BMI and vitD levels. All parameters were compared, then the correlations of those parameters were investigated in the groups and GDM subgroups. RESULTS:VitD levels were statistically insignificantly low in the GDM group and also in the older, multiparous, veiled, and obese GDM subgroups. Cal and PTH levels were not different in both groups. The vitD deficient and obese GDM subgroups had significantly higher Cal levels than their opposite subgroups. There was a positive correlation between Cal and BMI in the GDM group and in the VitD deficient, older, and veiled GDM subgroups. Positive correlation between vitD and C-peptide was found only in the obese GDM subgroup. In the logistic regression analysis including GDM subgroups and calcium metabolism hormones, except younger age (OR=0.116 (95% CI=0.04-0.338, p=<0.001)), VitD, active VitD, Cal, and PTH had no effect on GDM prediction. CONCLUSION:Although no significant difference was found in the VitD, Cal and PTH levels of the GDM patients during the summer season, it was thought that VitD could play a role in the obese GDM patients. It was also concluded that Cal and PTH did not have roles in gestational diabetes mellitus. Larger, carefully designed studies including throughout the pregnancy and postpartum periods and seasonal variations are required.

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“…Because PA patients did not receive PTH examination routinely, we could not get this data and analyze the relationship between PTH and DM. However, some studies did find that increased PTH was associated with decreased insulin sensitivity and pancreatic beta-cell function (36,37).…”

Section: Discussionmentioning

confidence: 99%

Higher Blood Urea Nitrogen and Urinary Calcium: New Risk Factors for Diabetes Mellitus in Primary Aldosteronism Patients

et al. 2020

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The aim of the study was to investigate the prevalence and risk factors of diabetes mellitus (DM) in primary aldosteronism (PA) patients.Methods: This case-control study enrolled 259 PA patients in West China Hospital, China from January 2016 to January 2019. Patients were divided into three groups: PA group, PA + impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) group and PA + DM group. Clinical characteristics (like age and sex) and laboratory variables (like plasma aldosterone concentration and plasma renin activity) were compared between three groups. Univariate and multivariate logistic regression analyses were performed to determine risk factors for DM in PA patients. The association of random blood glucose with the above-mentioned factors were also investigated by Pearson correlation analyses. Nomogram model was developed to predict the probability of DM in PA patients.Results: 49 (18.9%) patients were diagnosed with DM and 22 (8.5%) with IFG/IGT in 259 PA patients. Apart from older age, male, higher body mass index, higher triglycerides and lower cholesterol, we found that higher blood urea nitrogen (BUN) and higher 24 h urinary calcium (Ca) might be potential new risk factors for dysglycemia. The nomogram model for DM in PA patients had a good predictive accuracy, with the area under the curve of receiver operating characteristic of 0.839 (95% CI 0.784-0.893).Conclusions: PA patients were more likely to have DM compared with general population. Apart from older age, overweight and dyslipidemia, higher BUN and excessive excretion of urinary Ca may also be the new potential risk factors for DM in PA patients.

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Association of Vitamin D and Parathyroid Hormone with Insulin Sensitivity, Beta Cell Function and Gestational Diabetes in Pregnancy: A Cross-Sectional, Observational Study

Cited by 15 publications

References 28 publications

The Level of Nesfatin -1, Calcium and Vitamin D in Women with Gestational Diabetes Versus Control

The Level of Nesfatin -1, Calcium and Vitamin D in Women with Gestational Diabetes Versus Control

Gestasyonel Di̇yabetes Melli̇tus İle D Vi̇tami̇ni̇, Kalsi̇toni̇n Ve Parathormon İli̇şki̇si̇

Higher Blood Urea Nitrogen and Urinary Calcium: New Risk Factors for Diabetes Mellitus in Primary Aldosteronism Patients

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