Association of vitamin A status with lung function in children and adolescents with cystic fibrosis

Loukou, Ioanna; Moustaki, Maria; Sardeli, Olympia; Plyta, Marina; Katsagoni, Christina N.; Douros, Konstantinos

doi:10.1002/ped4.12270

Cited by 2 publications

(3 citation statements)

References 28 publications

(33 reference statements)

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“…Low levels of vitamin A are observed in patients with CF, because of a pancreatic insufficiency, which predisposes them to the malabsorption of fat and fat-soluble vitamins [ 91 ]. Vitamin A is important for vision, epithelial differentiation and resistance to infectious diseases, as well as for the antioxidant properties of its precursor, beta-carotene [ 92 ].…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

“…In addition, the requirement of vitamin A may be increased by the oxidative stress linked to inflammation [ 92 ]. However, until an optimal range for serum retinol levels in CF has been defined, clinicians should aim for the minimum vitamin A supplementation dosage necessary to reach sufficient serum retinol levels to prevent deficiency and avoid hypervitaminosis A, which could lead to bone disease and liver damage [ 91 ].…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

“…The ESPGHAN guidelines affirm that in CF patients with PI, a daily provitamin beta carotene dose of 1 mg/kg body weight/day for 12 weeks, followed by a maintenance dose (maximum of 10 mg/day) was found to be efficacious and safe for children aged six to 18 years [ 10 , 91 , 94 ]. The administration of beta-carotene, i.e., a precursor of vitamin A, is considered safer than retinol because it is subject to negative feedback control [ 95 , 96 ].…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

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Nutritional Care in Children with Cystic Fibrosis

et al. 2023

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Patients with cystic fibrosis (CF) are prone to malnutrition and growth failure, mostly due to malabsorption caused by the derangement in the chloride transport across epithelial surfaces. Thus, optimal nutritional care and support should be an integral part of the management of the disease, with the aim of ameliorating clinical outcomes and life expectancy. In this report, we analyzed the nutrition support across the different ages, in patients with CF, with a focus on the relationships with growth, nutritional status, disease outcomes and the use of the CF transmembrane conductance regulator (CFTR) modulators. The nutrition support goal in CF care should begin as early as possible after diagnosis and include the achievement of an optimal nutritional status to support the growth stages and puberty development in children, that will further support the maintenance of an optimal nutritional status in adult life. The cornerstone of nutrition in patients with CF is a high calorie, high-fat diet, in conjunction with a better control of malabsorption due to pancreatic enzyme replacement therapy, and attention to the adequate supplementation of fat-soluble vitamins. When the oral caloric intake is not enough for reaching the anthropometric nutritional goals, supplemental enteral feeding should be initiated to improve growth and the nutritional status. In the last decade, the therapeutic possibilities towards CF have grown in a consistent way. The positive effects of CFTR modulators on nutritional status mainly consist in the improvement in weight gain and BMI, both in children and adults, and in an amelioration in terms of the pulmonary function and reduction of exacerbations. Several challenges need to be overcome with the development of new drugs, to transform CF from a fatal disease to a treatable chronic disease with specialized multidisciplinary care.

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Section: Fat-soluble Vitaminsmentioning

confidence: 99%

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

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Nutritional Care in Children with Cystic Fibrosis

et al. 2023

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Macronutrient and Micronutrient Intake in Children with Lung Disease

Knebusch,

Mansour,

Vazquez

et al. 2023

Nutrients

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This review article aims to summarize the literature findings regarding the role of micronutrients in children with lung disease. The nutritional and respiratory statuses of critically ill children are interrelated, and malnutrition is commonly associated with respiratory failure. The most recent nutrition support guidelines for critically ill children have recommended an adequate macronutrient intake in the first week of admission due to its association with good outcomes. In children with lung disease, it is important not to exceed the proportion of carbohydrates in the diet to avoid increased carbon dioxide production and increased work of breathing, which potentially could delay the weaning of the ventilator. Indirect calorimetry can guide the process of estimating adequate caloric intake and adjusting the proportion of carbohydrates in the diet based on the results of the respiratory quotient. Micronutrients, including vitamins, trace elements, and others, have been shown to play a role in the structure and function of the immune system, antioxidant properties, and the production of antimicrobial proteins supporting the defense mechanisms against infections. Sufficient levels of micronutrients and adequate supplementation have been associated with better outcomes in children with lung diseases, including pneumonia, cystic fibrosis, asthma, bronchiolitis, and acute respiratory failure.

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Association of vitamin A status with lung function in children and adolescents with cystic fibrosis

Cited by 2 publications

References 28 publications

Nutritional Care in Children with Cystic Fibrosis

Nutritional Care in Children with Cystic Fibrosis

Macronutrient and Micronutrient Intake in Children with Lung Disease

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