Association of visceral fat area with pre-frailty in Japanese community-dwelling older adults: a cross-sectional study

Su, Ya; Yuki, Michiko; Ogawa, Natsuka

doi:10.1186/s12877-022-03377-w

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…Glycoprotein acetyls are markers of in ammation and they may contribute to in ammaging, the low grade in ammation occurring during aging predisposing to many age-related diseases (Franceschi et al, 2014). A very recent study demonstrated that glycoprotein acetyls are positively associated with frailty index in older age (Bålsrud et al, 2024), however, no study has associated glycoprotein acetyls with EAA before. While our ndings are supported by the previous studies on in ammaging and frailty in older age, it also adds to the literature by demonstrating a direct link between glycoprotein acetyls and EAA, which is present already in early adulthood.…”

Section: Discussionmentioning

confidence: 99%

Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences

Drouard,

Suhonen,

Heikkinen

et al. 2024

Preprint

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Connections between the multi-ome and epigenetic age acceleration (EAA), and especially whether these are influenced by genetic or environmental factors, remain underexplored. We therefore quantified associations between the multi-ome comprising four layers – the proteome, metabolome, external exposome, and lifestyle – with six different EAA estimates. Two twin cohorts were used in a discovery-replication scheme, comprising respectively young (N=642; mean age= 22.3) and older (N=354; mean age=62.3) twins. Within-pair twin designs were used to assess genetic and environmental effects on associations. We identified 40 multi-omic factors, of which 28 were proteins, associated with EAA in the young twins while adjusting for sex, smoking, and body mass index. Within-pair analyses showed that genetic confounding heterogeneously affected these associations, with six multi-omic factors remaining significantly associated with EAA independent of genetic effects. Replication in older twins showed that some of these associations persist across adult generations.

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Section: Discussionmentioning

confidence: 99%

Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences

Drouard,

Suhonen,

Heikkinen

et al. 2024

Preprint

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“…Growing evidence, including our previous research [8,9], suggests that high adiposity, assessed by anthropometric measures such as body mass index (BMI) and waist circumference (WC) [10][11][12][13][14], as well as dualenergy X-ray absorptiometry (DXA)-derived measures such as fat mass index (FMI) and visceral adipose tissue (VAT) mass [14][15][16][17][18][19], is an important risk factor for pre-frailty and frailty. Given the rising obesity epidemic across all age groups [20], this is of major concern.…”

Section: Introductionmentioning

confidence: 99%

Does the association between adiposity measures and pre-frailty among older adults vary by social position? Findings from the Tromsø study 2015/2016

Uchai,

Andersen,

Thoresen

et al. 2024

BMC Public Health

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Introduction Pre-frailty provides an ideal opportunity to prevent physical frailty and promote healthy ageing. Excess adiposity has been associated with an increased risk of pre-frailty, but limited studies have explored whether the association between adiposity measures and pre-frailty varies by social position. Methods We used data from the seventh survey of the Tromsø Study (Tromsø7) conducted in 2015–2016. Our primary sample consisted of 2,945 women and 2,794 men aged ≥ 65 years. Pre-frailty was defined as the presence of one or two of the five frailty components: low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity. Adiposity was defined by body mass index (BMI), waist circumference (WC), fat mass index (FMI) and visceral adipose tissue (VAT) mass. Education and subjective social position were used as measures of social position. Poisson regression with robust variance was used to assess the association between adiposity measures and pre-frailty, and the interaction term between adiposity measures and social position measures were utilised to explore whether the association varied by social position. Results In our sample, 28.7% of women and 25.5% of men were pre-frail. We found sub-multiplicative interaction of BMI-defined obesity with education in women and subjective social position in men with respect to development of pre-frailty. No other adiposity measures showed significant variation by education or subjective social position. Regardless of the levels of education or subjective social position, participants with excess adiposity (high BMI, high WC, high FMI and high VAT mass) had a higher risk of pre-frailty compared to those with low adiposity. Conclusion We consistently observed that women and men with excess adiposity had a greater risk of pre-frailty than those with low adiposity, with only slight variation by social position. These results emphasize the importance of preventing excess adiposity to promote healthy ageing and prevent frailty among all older adults across social strata.

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Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015

Uchai

Andersen

Johansson

et al. 2023

The Journal of nutrition, health and aging

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Objectives Aging is associated with changes in body composition. Excess adiposity among older adults has been linked with metabolic syndromes and aggravated age-associated decline in physical functioning. Few longitudinal studies have explored the association between dual-energy X-ray absorptiometry (DXA)-derived total as well as central adiposity measures and frailty. We examined the association of DXA-derived total and central adiposity with pre-frailty/frailty among Norwegian adults after 8 years of follow-up. Design Prospective observational study. Setting Community-dwelling adults from Tromsø, Norway. Measurements Adiposity was defined by fat mass index (FMI) and visceral adipose tissue (VAT) mass assessed using DXA measures. Frailty status was assessed by low grip strength, slow walking speed, exhaustion, unintentional weight loss and low physical activity level. Pre-frail and frail participants at baseline were excluded. Sex-stratified multivariable logistic regression models were used to investigate the association. Results Participants comprised 234 women (mean age 68 years) and 146 men (mean age 69 years) attending the population-based Tromsø Study in 2007–2008 (Tromsø6) and 2015–2016 (Tromsø7). At the end of follow-up, 25.6% of the women and 27.4% of the men were pre-frail/frail. Compared with women in the lowest tertiles, those in the highest tertile of baseline FMI (odds ratio [OR] 4.42, 95% confidence interval [CI] 1.88–10.35) and VAT mass (OR 2.47, 95% CI 1.10–5.50), respectively had higher odds for pre-frailty/frailty at follow-up. Conclusion We found a higher likelihood of pre-frailty/frailty in later years among women with general and central adiposity in adulthood, highlighting the importance of preventing excess adiposity for healthy aging.

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Association of visceral fat area with pre-frailty in Japanese community-dwelling older adults: a cross-sectional study

Cited by 6 publications

References 39 publications

Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences

Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences

Does the association between adiposity measures and pre-frailty among older adults vary by social position? Findings from the Tromsø study 2015/2016

Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015

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