Association of VDR gene BsmI polymorphism with temporomandibular joint disorders: A case control study in Kashmiri population

Bashir, Shabroza; Shah, Aasim Farooq; Dar, Jahangir I.; Misgar, Irshad A.; Sabba, Anjum; Firdous, Parveena; Hakim, Tajamul; Mir, Syed

doi:10.1016/j.genrep.2022.101613

Cited by 3 publications

(9 citation statements)

References 23 publications

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“…The publication year of the studies that were included in this review ranged between 2017 [ 35 , 36 ] and 2022 [ 37 ]. The nationalities of the studies included in this review were as follows: seven studies (69%) were conducted in Asia (two in Iran [ 38 , 39 ], three in India [ 36 , 37 , 40 ], one in Iraq [ 35 ], and one in Korea [ 41 ]); one study (8%) was conducted in Europe (in Norway [ 42 ]); and the remaining three studies (23%) were Turkish [ 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven were cross-sectional studies [ 35 , 36 , 37 , 38 , 39 , 42 , 45 ], two had a prospective observational design [ 41 , 43 ], one was a prospective case-control study [ 44 ], and one study was a randomized controlled trial [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…Most of the human subjects were female ( n : 662), while 244 were male. The studies conducted by Bashir et al [ 37 ], Gupta et al [ 40 ], and Yilmaz et al [ 45 ] did not characterize the sample for gender. The mean ages of the subjects who were included in this study ranged from 8.50 ± 43.02 years [ 35 ] to 57.2 ± 4.6 years [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

“…Three studies [ 37 , 44 , 45 ] assessed the genotype and the frequency of VDR polymorphisms (BsmI, Apa1, and Taq1). Bashir et al [ 37 ] showed that the BsmI polymorphism was significantly higher for the mutant genotype/allele in the TMD patients ( p = 0.0015), while a significant association between the TMJ internal derangement development and the allelic and genotypic frequencies of BsmI.…”

Section: Resultsmentioning

confidence: 99%

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Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Ferrillo

Lippi

Giudice

et al. 2022

JCM

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Although a growing body of literature has been emphasizing the role of vitamin D in oral health, there is still a gap of knowledge regarding the correlation between temporomandibular disorders (TMDs) and vitamin D. Therefore, the aim of this systematic review was to assess the linkage between hypovitaminosis D and TMDs to map the current literature in this field. On 10 September 2022, PubMed, Scopus, and Web of Science databases were systematically searched from the date of their inception to identify the studies that had assessed patients with TMDs. The primary outcome assessed in this review was the relationship between hypovitaminosis D and TMDs. Out of the 329 studies identified, 13 studies met the eligibility criteria and were included in the present work. Seven studies assessed the relationship between vitamin D and TMDs, reporting that vitamin D serum levels are lower in patients with TMDs. Our results suggested that vitamin D receptor (VDR) polymorphisms might have a role in TMDs’ development. However, the quality assessed underlined that only one study did not present a serious risk of bias. Further good-quality studies are needed to clarify the linkage between vitamin D deficiency and TMDs, but the evidence currently available has suggested potential correlations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Ferrillo

Lippi

Giudice

et al. 2022

JCM

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“…Other authors found no association between the VDR gene BsmI polymorphism in postmenopausal women with osteoporosis [ 28 ] and obese Egyptian male-medical students [ 29 ]. A case-control study in the Kashmiri population has reported a significant association of VDR gene BsmI polymorphism with temporomandibular joint disorders [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Vitamin D Receptor Gene BsmI Polymorphism and Fibromyalgia Syndrome

Parvez¹,

Fatima²,

Mehdi³

et al. 2022

Cureus

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Vitamin D receptor (VDR) has been proposed as a possible marker for fibromyalgia syndrome (FMS). The purpose of this study is to characterize the expression pattern of BsmI polymorphism (rs1544410) in the VDR gene in women with FMS and the genotype-phenotype association. MethodsA total of 105 FMS patients and 105 controls were included in this study. VDR gene BsmI polymorphism was assessed by polymerase chain reaction (PCR) and restriction fragment length polymerase (RFLP) method. ResultsThere was no significant difference in the frequency distribution of both genotypes and alleles for VDR gene BsmI polymorphism between FMS patients and controls (p>0.05). The frequencies of BB, Bb, and bb in the VDR gene BsmI polymorphism were 19%, 43%, and 37% in patients, while in controls were 22.9%, 55.2%, and 21.9%. However, we did not find any significant association between the clinical symptoms of this disease and VDR BsmI genotypes among FMS patients (p>0.05). ConclusionsThe relationship between the VDR gene BsmI polymorphism and FMS could not be determined in this study. However, further studies with a larger sample size may be required to show a relation between the VDR gene BsmI polymorphism and FMS.

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Title: Vitamin D Serum Levels and Temporomandibular Disorders: A Systematic Review and Meta-analysis

Tabrizi,

Khanzadeh,

Jamasbi

et al. 2024

Archives of Oral Biology

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Association of VDR gene BsmI polymorphism with temporomandibular joint disorders: A case control study in Kashmiri population

Cited by 3 publications

References 23 publications

Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Relationship Between Vitamin D Receptor Gene BsmI Polymorphism and Fibromyalgia Syndrome

Title: Vitamin D Serum Levels and Temporomandibular Disorders: A Systematic Review and Meta-analysis

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