Association of Vascular Endothelial Growth Factor Polymorphisms with Asthma in Tunisian Children

Lachheb, Jihene; Chelbi, Hanène; Dhifallah, Imen Ben; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, A.

doi:10.1177/117762500800200003

Cited by 10 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the promoter region of the VEGF gene, we found no significant difference between the asthma and control groups, although rs699947 has been reported to be associated with VEGF plasma level, pre-school lung function, and lung cancer risk (Kreiner-Møller et al, 2013;Fan et al, 2015), and the G allele of rs2010963 has been reported to be associated with asthma (Lachheb et al, 2008). These differences probably result from disparities in the sample sizes, populations, and clinical phenotypes.…”

Section: Discussioncontrasting

confidence: 51%

“…We found that the T allele in the asthma group was present in a significantly higher proportion than in the control group. The VEGF rs3025039 SNP is not only associated with asthma (Lachheb et al, 2008); like the VEGF rs3025020 polymorphism, rs3025039 is also associated with other diseases, for example, bisphosphonate-related osteonecrosis of the jaw (Choi et al, 2015) and ovarian cancers (Janardhan et al, 2015). Compared with healthy controls, the frequency of the T allele of rs3025039 is significantly higher in patients with HCH (He et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

Lu¹,

Zhao²,

Fu³

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. It has been proven that vascular endothelial growth factor (VEGF) is involved in airway restoration and the development of asthma. We sought to examine the relevance of VEGF gene polymorphisms to asthma in the Chinese Han population. We extracted the whole genomic DNA from the peripheral blood of 471 participants, including 226 patients with asthma and 245 healthy controls. Seven single nucleotide polymorphisms (SNPs) of the VEGF gene were genotyped using the MassARRAY system. The data were then analyzed using HaploView 4.0 and SPSS 20.0 softwares. When comparing the asthma and control groups, significant differences were found in the genotype frequencies of rs3025020 and rs3025039 (P = 0.001 and P = 0.011, respectively). The T alleles in rs3025020 and rs3025039 were significantly more prevalent in the asthma group than in controls (P = 0.0003, P = 0.001, respectively). Furthermore, a strong linkage 2 H.Y. Lu et al.

show abstract

Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

Lu¹,

Zhao²,

Fu³

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Several studies have analyzed the -2549 I/D polymorphism in the context of susceptibility to various diseases like Behcet's disease (BD) (Salvarani et al, 2004), asthma (Lachheb et al, 2008), HCC (He et al, 2010), recurrent miscarriages (Aggarwal et al, 2011), and end-stage renal disease (Prakash et al, 2012). Association of the DD genotype of the -2549 I/D polymorphism has been reported with diabetic retinopathy (Awata et al, 2002;Buraczynska et al, 2007), diabetic nephropathy (Yang et al, 2003), peripheral artery disease (Bleda et al, 2012), and end-stage renal disease (Prakash et al, 2012).…”

mentioning

confidence: 99%

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

Kapahi

Manjari²,

Uppal³

et al. 2013

Genetic Testing and Molecular Biomarkers

View full text Add to dashboard Cite

“…All asthmatics and controls were genotyped using polymerase chain reaction (PCR) following Lachheb et al [22] for the verification of the presence of the VEGF polymorphism, which comprises the addition or the loss of 18 base pairs (18 bp) within the promoter region at position -2549 -2567. The concentration of the isolated DNA and its purity were identified using a spectrophotometer (NanoDrop, Thermo…”

Section: Genotyping Of the Vegf Polymorphismmentioning

confidence: 99%

The –2549 –2567 del18 Polymorphism in VEGF and Irreversible Bronchoconstriction in Asthmatics

Gomułka

Liebhart

Jaskuła

et al. 2019

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

Background: While the importance of vascular endothelial growth factor (VEGF) in the pathogenesis of several diseases (eg, neoplasms) has been proven, its role in asthma, especially in terms of the potential associations between genetic variants of VEGF and airway remodeling, has received relatively little attention. Objectives: This study aimed to evaluate the possible connection between a genetic factor, ie, the polymorphism del/ins in the VEGF promoter region, and airway remodeling potential in asthmatics with and without irreversible bronchoconstriction. Materials and Methods: The study population comprised 82 patients with asthma (of whom 42 had irreversible bronchoconstriction) and a group of 40 controls. DNA was isolated from peripheral blood leukocytes. Polymerase chain reaction was used to type the VEGF (18-bp deletion/insertion) gene polymorphism at loci -2549 -2567. Other factors (ie, smoking, disease duration) were also taken into consideration. Results: The del/del genotype was found in 74.39% of patients with asthma (P=.031; OR=2.38), 80.95% of patients with irreversible bronchoconstriction (P=.012; OR=3.48), and 67.5% patients with reversible bronchoconstriction (P=.251; OR=1.70). The proportion of smokers to nonsmokers was higher (P=.032) and disease duration was longer (P=.041) in patients with irreversible bronchoconstriction than in those with reversible bronchoconstriction. Conclusions: Our results showed that the risk of irreversible bronchoconstriction in asthmatics was associated with the presence of the del18 genotype at the -2549 -2567 position in the promoter region of the VEGF gene, as were disease duration and other factors such as smoking. ResumenAntecedentes: Aunque se ha demostrado la importancia del factor de crecimiento endotelial vascular (VEGF) en la patogénesis de varias enfermedades (p. ej. neoplasias), los datos relativos al asma son escasos, especialmente los relacionados con las posibles asociaciones entre las variantes genéticas de VEGF y la remodelación de las vías respiratorias. Objetivos: En este estudio se propuso evaluar la posible relación entre un factor genético como el polimorfismo del/ins en la región promotora de VEGF y el potencial de remodelación de las vías aéreas en los asmáticos con y sin broncoconstricción irreversible. Materiales y métodos: en el estudio participaron 82 pacientes con asma (42 pacientes con broncoconstricción irreversible) y un grupo de 40 controles. El ADN fue extraído de leucocitos de sangre periférica. Para la tipificación del polimorfismo del gen VEGF (delección / inserción de 18 pb) en loci -2549 -2567 se utilizó el método de reacción en cadena de la polimerasa (PCR). Se consideraron también otros factores (fumar, duración de la enfermedad). Resultados: El genotipo del/del se encontró en el 74,39% de pacientes con asma (p = 0,031; OR = 2,38), el 80,95% de los pacientes con broncoconstricción irreversible (p = 0,012; OR = 3,48) y el 67,5% de los pacientes con broncoconstricción reversible (p = 0,251; OR = 1,70). La proporción de fumado...

show abstract

Association of Vascular Endothelial Growth Factor Polymorphisms with Asthma in Tunisian Children

Abstract: Background: Previous studies demonstrated that the vascular endothelial growth factor (VEGF) was being implicated in the airways infl ammation and remodeling process in patients with asthma.

Cited by 10 publications

References 32 publications

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

Polymorphisms in the vascular endothelial growth factor (VEGF) gene associated with asthma

Association of −2549 Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor with Breast Cancer in North Indian Patients

The –2549 –2567 del18 Polymorphism in VEGF and Irreversible Bronchoconstriction in Asthmatics

Contact Info

Product

Resources

About