Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Susceptibility and Clinicopathologic Characteristics of Colorectal Cancer

Chae, Yee Soo; Kim, Jong Gwang; Sohn, Sang Kyun; Cho, Yoon Young; Ahn, Byung Min; Moon, Joon Ho; Jeon, Seoung Woo; Park, Jae Yong; Lee, In Taek; Choi, Gyu Seog; Jun, Soo Han

doi:10.3346/jkms.2008.23.3.421

Cited by 46 publications

(44 citation statements)

References 23 publications

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“…Other studies, mostly involving a relatively small population sample, found different associations between the investigated SNPs and tumor development. Chae et al (29) found that the -634 G/ +936 T combination was associated with a decreased susceptibility to CRC in a Korean population, which in part contradicts our findings. We chose to combine +936 C/T with -2578 C/A rather than -634 G/C.…”

Section: Discussioncontrasting

confidence: 57%

Analysis of VEGF polymorphisms, tumor expression of VEGF mRNA and colorectal cancer susceptibility in a Swedish population

Ungerbäck

Elander²,

Dimberg³

et al. 2009

Mol Med Rep

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Section: Discussioncontrasting

confidence: 57%

Analysis of VEGF polymorphisms, tumor expression of VEGF mRNA and colorectal cancer susceptibility in a Swedish population

Ungerbäck

Elander²,

Dimberg³

et al. 2009

Mol Med Rep

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“…Our findings were similar to those of previous studies conducted in other populations in which no correlation between the VEGF +936 C>T variant and CRC susceptibility was observed (Hofmann et al, 2008;Dassoulas et al, 2009;Wu et al, 2009). Nonetheless, the TT genotype was shown to correlate with the advanced stage of CRC, a higher serum level of CA19-9, a higher histological grade of CRC tumors, and poorer patient prognosis (Chae et al, 2008). Furthermore, Nakasaki et al, (2002) demonstrated that the expression of VEGF varied significantly across different stages of CRC progression, and was correlated with the metastasis and tumor vascularity of CRC neoplasms.…”

Section: Discussionsupporting

confidence: 82%

Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population

Lau¹,

Roslani²,

Lian³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Growth factors are polypeptides that are critical for the initiation, progression, and metastasis of cancer. Most tumor cells are capable of synthesizing particular growth factors leading to constitutive pathway activation in these cells through autocrine signaling. Epidermal growth factor (EGF) is a potent mitogenic peptide that exerts direct effects on the proliferation and differentiation of tumor cells in carcinogenesis. By contrast, vascular endothelial growth factor (VEGF) is vital for the invasion and metastasis of neoplasms through the formation of new blood vessels from mature endothelial cells. In this study, we investigated the association between functional polymorphisms of both the EGF and VEGF genes and colorectal cancer (CRC) susceptibility. A total of 130 CRC patients and 212 healthy controls were recruited for this case-control study. Genotyping of genetic variants was conducted via real-time polymerase chain reaction (PCR) amplification with allelespecific TaqMan probes. None of the genotypes of the EGF +61 A>G and VEGF +936 C>T variants was significantly associated with CRC susceptibility among the Malaysian subjects evaluated (P > 0.05). The observed frequency distributions of the EGF +61 A>G polymorphism genotypes showed ethnic heterogeneity, which was not the case for the VEGF +936 C>T genotypes. In conclusion, no positive correlation between these functional polymorphisms and CRC risk was found in this Malaysian population. Studies of the EGF and VEGF genes and CRC susceptibility are scarce, and the results reported thus far differ from one population to another. Hence, more replication studies are warranted before any firm conclusions can be made.

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“…Recently, increasing number of studies have highlighted the association between the VEGF -634 G/C polymorphism and various cancers including lung, gastric, colorectal, and cervical cancer (Jin et al, 2005;Lee et al, 2005;Jacobs et al, 2006;Kataoka et al, 2006;Sfar et al, 2006;Tzanakis et al, 2006;Balasubramanian et al, 2007;Garcia-Closas et al, 2007;Hsiao et al, 2007;Amano et al, 2008;Chae et al, 2006Chae et al, , 2008Hofmann et al, 2008;Ke et al, 2008;Zhai et al, 2008a,b;Al-Moundhri et al, 2009;Dassoulas et al, 2009;Guan et al, 2009;Maltese et al, 2009;Ungerbäck et al, 2009;Bruyère et al, 2010;Kim et al, 2010;Zhou et al, 2011;Supic et al, 2012;Deng et al, 2013;Luo et al, 2013;Wang et al, 2014). Due to the substantial differences in sample size, these studies failed to accurately define the genetic susceptibility of the VEGF -634 G/C polymorphism in development of cancer.…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis

Jy¹,

Ji²,

Ch³

2015

Genet. Mol. Res.

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ABSTRACT. The association between vascular endothelial growth factor (VEGF) gene polymorphisms and risk of cancer has been investigated in several studies published previously; however, the individual results are inconclusive. Therefore, we performed a metaanalysis to establish evidence for an association between the VEGF -634 G/C polymorphism and risk of cancer. We searched PubMed, Medline, and Korean Studies Information Service System databases and identified 29 case-control studies, containing data of 25,324 individuals, for this meta-analysis. The odds ratio (OR) and 95% confidence interval (95%CI) were used to determine the strength of the association. Overall, no significant association was detected in the allele model (G allele vs C allele, OR = 0.98, 95%CI = 0.93-1.03), dominant model (G/G+G/C vs C/C, OR = 1.00, 95%CI = 0.90-13907 Meta-analysis of VEGF polymorphism in cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13906-13914 (2015) 1.11), or recessive model (G/G vs G/C+C/C, OR = 0.96, 95%CI = 0.89-1.03). The meta-analysis results suggest that the VEGF -634 G/C polymorphism may not be related to the development of cancer. However, additional studies with larger sample size are required in order to provide supporting evidence.

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Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Susceptibility and Clinicopathologic Characteristics of Colorectal Cancer

Cited by 46 publications

References 23 publications

Analysis of VEGF polymorphisms, tumor expression of VEGF mRNA and colorectal cancer susceptibility in a Swedish population

Analysis of VEGF polymorphisms, tumor expression of VEGF mRNA and colorectal cancer susceptibility in a Swedish population

Association between EGF and VEGF functional polymorphisms and sporadic colorectal cancer in the Malaysian population

Vascular endothelial growth factor -634 G/C polymorphism and risk of cancer: an updated meta-analysis

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