Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats

Jaleel, Zaroug; Blasberg, Elizabeth; Troiano, Chelsea; Montanaro, Paige; Mazzilli, Sarah A.; Gertje, Hans; Crossland, Nicholas A.; Platt, Michael; Spiegel, Jeffrey H.

doi:10.1111/wrr.12945

Cited by 12 publications

(7 citation statements)

References 47 publications

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“…Waterman et al (2016) identified smoking as a significant risk factor for increased failure rates in meniscus transplant surgeries, suggesting that tobacco use may negatively affect healing and long-term success [16]. The current literature has well established that smoking overall significantly impairs tissue healing, a crucial factor in orthopedic conditions such as meniscus tears [15,17,27,109]. Smoking has been shown to decrease vascular endothelial growth factor expression and microvessel density in healing tissues, which are vital for effective wound healing [109].…”

Section: Discussionmentioning

confidence: 99%

“…The current literature has well established that smoking overall significantly impairs tissue healing, a crucial factor in orthopedic conditions such as meniscus tears [15,17,27,109]. Smoking has been shown to decrease vascular endothelial growth factor expression and microvessel density in healing tissues, which are vital for effective wound healing [109]. In the broader scheme of orthopedic-related injuries, smoking significantly impacts the outcomes of knee ligament surgeries, such as Anterior Cruciate Ligament (ACL) and meniscus reconstruction.…”

Section: Discussionmentioning

confidence: 99%

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Examining the Evidence Regarding Smoking and Patient Outcomes for Isolated Meniscus Pathology: A Comprehensive Systematic Review and Meta-Analysis

Anaspure,

Patel,

Baumann

et al. 2024

Life

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Smoking is a well-known cause of impairment in wound healing and postoperative outcomes; however, its effects on treating meniscus issues remain unclear. This study assesses the relationship between smoking and meniscus treatment outcomes. PubMed, Scopus, Cochrane, and CINAHL were searched from inception to 24 December 2023. Inclusion criteria encompassed studies examining smoking’s impact on patient outcomes regarding meniscus pathology. A secondary PubMed search targeted randomized controlled trials (RCTs) in the top ten orthopedic journals focusing on meniscus pathology and smoking as a demographic variable. Meta-analysis of six studies (n = 528) assessed meniscus failure rate based on smoking status. Eighteen observational studies (n = 8353 patients; 53.25% male; mean age: 51.35 ± 11.53 years; follow-up: 184.11 ± 117.34 months) were analyzed, covering meniscus repair, meniscectomy, allograft transplant, conservative care, and arthroscopy. Results showed four studies (36.36%) linked smoking with worse meniscus repair outcomes, while seven studies (63.64%) did not find significant associations. Meta-analysis from six studies showed no significant impact of smoking on repair failure (p = 0.118). Regarding meniscectomy, one study (33.33%) identified a significant association with smoking, but two did not. Only one (3.8%) of the RCTs in leading orthopedic journals included smoking as a factor. The evidence on smoking’s effect on meniscus treatment is mixed, necessitating further investigation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Examining the Evidence Regarding Smoking and Patient Outcomes for Isolated Meniscus Pathology: A Comprehensive Systematic Review and Meta-Analysis

Anaspure,

Patel,

Baumann

et al. 2024

Life

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“…This is relevant for assessing both disease and surgical risk; an association with e‐cig exposure and poor wound healing and flap failure has been reported in both animal models and surgical patients. 97 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 Unfortunately, due to the variable nicotine content of e‐cig products, it can be difficult to obtain a quantitative estimate of usage (ie, pack year equivalent).…”

Section: Discussionmentioning

confidence: 99%

“…It is important, then, to ask about specific forms of tobacco consumption, both inhaled and smokeless, when assessing a patient's tobacco history. This is relevant for assessing both disease and surgical risk; an association with e‐cig exposure and poor wound healing and flap failure has been reported in both animal models and surgical patients 97,104‐111 . Unfortunately, due to the variable nicotine content of e‐cig products, it can be difficult to obtain a quantitative estimate of usage (ie, pack year equivalent).…”

Section: Discussionmentioning

confidence: 99%

Impact of Electronic Cigarettes on the Upper Aerodigestive Tract: A Comprehensive Review for Otolaryngology Providers

2023

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Objective The use and effects of electronic (e)‐cigarettes (e‐cigs) are particularly relevant for otolaryngology providers as tobacco plays a major role in benign and malignant diseases of the upper aerodigestive tract. This review aims to (1) summarize the recent policies regarding e‐cigs and important patterns of use and (2) serve as a comprehensive resource for clinical providers on the known biologic and clinical effects of e‐cigs on the upper aerodigestive tract. Data Sources PubMed/MEDLINE. Review Methods We conducted a narrative review on (1) general information on e‐cig use and informative findings in the lower respiratory system and a comprehensive review on (2) the effects of e‐cigs on cell and animal models and the clinical implications of these products on human health as is relevant to otolaryngology. Conclusions Although e‐cigs are likely less harmful than conventional cigarettes, preliminary research on e‐cigs suggest several deleterious effects including in the upper aerodigestive tract. Due to this, there has been increased interest in restricting e‐cig usage, particularly among the adolescent population, and caution in recommending e‐cigs to current smokers. Implications for Practice Chronic e‐cig use is likely to have clinical implications. It is critical for otolaryngology providers to be aware of the rapidly changing regulations and use patterns regarding e‐cigs and how e‐cigs influence human health, particularly with regards to the upper aerodigestive tract, to accurately council patients regarding potential risks and benefits of use.

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“…In addition to dysfunction, vascular oxidative stress [42,43], decreased of vascular endothelial growth factor (VEGF) expression, and a reduction of the density of capillaries have been reported [44]. There is significantly increased carotid plaque burden that young adult smokers and vapers exhibit compared with matched nonsmokers [45 ▪ ].…”

Section: Vaping Consequences On the Vascular Endotheliummentioning

confidence: 99%

Cardiovascular consequences of vaping

Echeagaray

Savko

Gallo

et al. 2022

Current Opinion in Cardiology

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Purpose of reviewVaping activity continues to increase worldwide. Promoted as a 'healthier' alternative to traditional smoking, emerging evidence indicates 'healthier' should not be confused with 'harmless'. Direct inhalation exposure of the respiratory tract in experimental research demonstrates pulmonary consequences of vaping. However, cardiovascular consequences of vaping are poorly characterized and are a priority area of research to reveal vaping-induced pathogenesis. Recent findings:Alterations in cardiovascular homeostasis, inflammation, and molecular changes following vaping exposure demonstrate vaping-related health concerns. Summary:This review summarizes cardiovascular consequences of vaping from cumulative research findings. Strategic application of emerging technologies to understand the impact of vaping upon the cardiovascular system will be essential for defining the true risks of vaping-associated injury.

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Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats

Cited by 12 publications

References 47 publications

Examining the Evidence Regarding Smoking and Patient Outcomes for Isolated Meniscus Pathology: A Comprehensive Systematic Review and Meta-Analysis

Examining the Evidence Regarding Smoking and Patient Outcomes for Isolated Meniscus Pathology: A Comprehensive Systematic Review and Meta-Analysis

Impact of Electronic Cigarettes on the Upper Aerodigestive Tract: A Comprehensive Review for Otolaryngology Providers

Cardiovascular consequences of vaping

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