Association of urinary triclosan and methyl-triclosan levels with predictive indicators of cardiovascular disease and obesity in children and adolescents in 2020 (case study: Kerman, Iran)

Abstract

Background: Exposure of children and adolescents to endocrine disrupting chemicals (EDCs) causes the development of non-communicable diseases. Triclosan (TCS) is a fat-soluble antimicrobial agent, and methyl-triclosan (MTCS) is the predominant metabolite of TCS. The increasing use of consumables TCS (toothpaste, mouthwash, personal care products) in human has raised concerns about human health. Methods: The urinary concentrations of TCS and MTCS were measured by GC/MS. Lipid profiles (TG, TC, LDL, and HDL), anthropometric parameters (WC, BMI z-score, and BMI), FBS, SBP, and DBP tests were performed on 79 children and adolescents. Results: Of 79 people included as the study population, 42 subjects (53.16%) were males. Most of the study population as 32 subjects (40.50%) were obese. The mean concentrations of TCS and MTCS in the obese population were 5.47 ± 2.99 and 2.32 ± 1.04 µg/L, respectively. After adjusting for possible confounding factors, the results showed that a one-unit increase in DBP caused a 0.03 units increase in TCS levels in male subjects (P=0.01). A one-unit increase in DBP also caused a 0.02 units increase in MTCS (P=0.001). There was a significant relationship between TCS and HDL (OR=0.90, P=0.005), LDL (OR=1.13, P=0.01), and TG (OR =1.05, P<0.0001). There was also a significant relationship between MTCS and HDL (OR=0.88, P=0.001), LDL (OR=1.03, P=0.009), and TG (OR=1.04, P < 0.0001). Conclusion: According to the results, there is a relationship between TCS, MTCS, and predictive indicators of cardiovascular diseases and obesity.

Triclosan: A Small Molecule with Controversial Roles

“…Recently, exposure to TCS and TCC has been associated with increased risk of childhood obesity, by examining in first morning urine of children aged 7–11 years by liquid chromatography coupled to mass spectrometry [ 195 ]. In another study in children, a relationship between TCS and its metabolite MTCS with predictive indicators of cardiovascular diseases and obesity was found [ 196 ]. A recent study on a total of 674 infertile Chinese women at 18–45 years of age showed that TCS exposure at a relatively low level was associated with PCOS [ 197 ].…”

Measurement of Urinary Triclocarban and 2,4‐Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran

“…People who are overweight and obese during childhood are more likely to develop obesity, cardiovascular diseases such as hypertension, hyperlipidemia, and atherosclerosis during adulthood [ 6 ]. However, the spread of cardiovascular disease does not begin in childhood and adolescence, but the risk factors for cardiovascular disease often start in childhood and adolescence [ 7 , 8 ].…”

“…Given the rapid increase in obesity in the young population, early detection of risk factors and their prompt treatment are important to prevent or delay the onset of late-stage heart disease complications [ 9 ]. The causes of obesity have been widely studied but are not yet well understood [ 8 , 12 ].…”

A Pilot Study on the Association of Lead, 8-Hydroxyguanine, and Malondialdehyde Levels in Opium Addicts’ Blood Serum with Illicit Drug Use and Non-Addict Persons

“…Pollutant concentrations in serum may be indicative of their circulation across organs in the human body. As a result, a high-throughput extraction approach based on a tiny volume of serum sample is required, as well as an instrumental analysis method capable of detecting minuscule levels of contaminants with high precision [ 17 , 18 , 19 ].…”