Association of urinary concentrations of phthalate metabolites with cardiometabolic risk factors and obesity in children and adolescents

Amin, Mohammad Mehdi; Ebrahimpour, Karim; Parastar, Saeed; Shoshtari-Yeganeh, Bahareh; Hashemi, Majid; Mansourian, Marjan; Poursafa, Parinaz; Fallah, Zahra; Rafiei, Nasim; Kelishadi, Roya

doi:10.1016/j.chemosphere.2018.07.172

Cited by 71 publications

(54 citation statements)

References 26 publications

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“…The mean concentration of MBP, MBzP, MEHP, and MEHHP found in this study were 13, 30, 20, and 44 times greater than those levels have reported by other studies in the US and European countries [6,11,12]. These results are in accordance with the ndings of Amin et al who previously reported a higher levels of exposure to phthalates in Iranian population [9]. Several factors including the sociodemographic, environmental, regional, size of study population and etc.…”

Section: Resultssupporting

confidence: 91%

Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population

Darvishmotevalli

Moradnia

Hosseini

et al. 2020

Preprint

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Background: This study aimed to examine the associations between the urinary concentrations of phthalate metabolites among a sample of Iranian pregnant women with anthropometric measures of neonates. Methods: Urine samples were obtained from 121 pregnant women at their first trimester of pregnancy; the levels of monobutyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), and mono (2-ethyl-5hydroxyhexyl) phthalate (MEHHP) metabolites were determined by gas chromatography mass spectrometry (GC/MS). The correlation between the urinary concentration of these metabolites and some socio-demographic factors of the participants (maternal education, age, family income, pre-pregnancy body mass index), their lifestyle variables (smoking habit, food pattern, and physical activity), cleaning products use data (cosmetic and household cleaning products) with anthropometric measures of neonates were investigated. Results: MBzP, MBP, MEHP, and MEHHP were detected in 100% of participants with the concentration ranged from 120 to 860 μg/g creatinine. Significant correlations were observed between the urinary levels of maternal MBzP (adjusted β =0.3 (0.001), p=0.03) and MEHHP and (adjusted β =0.3 (0.001), p=0.04) with the birth weight of female neonates. MBP (adjusted β = -0.3(0.02), p=0.04) and MBzP (adjusted β =-0.3 (0.001), p=0.02) were found negatively associated with head circumference in male and female newborns, respectively. Significant differences existed in the birth weight of infants whose mothers used plastic packaging for pickle and those who had history of passive smoking (p-value< 0.05). Conclusions: the studied metabolites had higher concentration in the Iranian pregnant women urine compared to the other countries. Higher levels of prenatal exposure to phthalate metabolites may adversely impact the health status of newborns.

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Section: Resultssupporting

confidence: 91%

Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population

Darvishmotevalli

Moradnia

Hosseini

et al. 2020

Preprint

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“…The authors also reported an increase in inflammatory and oxidative stress markers, which coincided with increased myocardial injury in DEHP‐treated animals. Similar findings have been observed in children with increased MEHP exposure, which was associated with obesity, elevated triglycerides and increased blood pressure in children age 6–18 years old (Amin et al, 2018). Most recently, a meta‐analysis study by Golestanzadeh et al concluded that phthalate exposure was associated with increased cardiometabolic risk factors in children (Golestanzadeh, Riahi, & Kelishadi, 2019).…”

Section: Di‐2‐ethylhexyl Phthalatesupporting

confidence: 81%

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

Ramadan

Cooper

Posnack

2020

Birth Defects Research

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Phthalates and bisphenols are high production volume chemicals that are used in the manufacturing of consumer and medical products. Given the ubiquity of bisphenol and phthalate chemicals in the environment, biomonitoring studies routinely detect these chemicals in 75-90% of the general population. Accumulating evidence suggests that such chemical exposures may influence human health outcomes, including cardiovascular health. These associations are particularly worrisome for sensitive populations, including fetal, infant and pediatric groups-with underdeveloped metabolic capabilities and developing organ systems. In the presented article, we aimed to review the literature on environmental and clinical exposures to bisphenols and phthalates, highlight experimental work that suggests that these chemicals may exert a negative influence on cardiovascular health, and emphasize areas of concern that relate to vulnerable pediatric groups. Gaps in our current knowledge are also discussed, so that future endeavors may resolve the relationship between chemical exposures and the impact on pediatric cardiovascular physiology.

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“…To reduce the effect of recall bias, the questionnaires were completed jointly by parents and their children. Accordingly, physical examinations, including measurements of weight, height, waist circumference, diastolic blood pressure (DBP), and systolic blood pressure (SBP), were conducted using the standards protocols [ 38 ]. Moreover, the body mass index (BMI) was calculated as wt (kg) divided by height squared (m 2 ).…”

Section: Methodsmentioning

confidence: 99%

Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents

Hashemi

Amin

Chavoshani

et al. 2021

Journal of Environmental and Public Health

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Introduction. Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents, living in Isfahan industrial city of Iran, were examined. Urine samples taken from the participants were analyzed for mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-exohexyl) phthalate (MEOHP), and mono-methyl phthalate (MMP). Results. Results showed that, among phthalate metabolites, MBP had the highest concentration, followed by MBzP, MEOHP, MEHHP, MEHP, and MMP. Concentrations of these metabolites had a significant relationship with some of the cardiometabolic risk factors including systolic blood pressure (SBP), fasting blood sugar (FBS), and triglycerides (TG) ( p < 0.05). Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) ( p < 0.05). Conclusion. Although urinary phthalate concentrations could not exactly reflect the long-term exposure level in the studied age groups, the consumption of phthalate-free products during childhood and adolescent development shall be assumed helpful in maintaining a healthy lifestyle. To confirm these findings and develop effective intervention strategies, it would be necessary to perform longitudinal studies on diverse population.

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Association of urinary concentrations of phthalate metabolites with cardiometabolic risk factors and obesity in children and adolescents

Cited by 71 publications

References 26 publications

Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population

Association Between Prenatal Phthalate Exposure and Anthropometric Measures of Newborns in a Sample of Iranian Population

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents

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