Association of unmet basic resource needs with frailty and quality of life among older adults with cancer—Results from the <scp>CARE</scp> registry

Williams, Grant R.; Fowler, Mackenzie E.; Giri, Smith; Dai, Chen; Harmon, Christian; Al‐Obaidi, Mustafa; Stephenson, Coryn; Bona, Kira; Landier, Wendy; Bhatia, Smita; Wolfson, Julie

doi:10.1002/cam4.6038

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Including a preference-based measure directly is the preferred option for obtaining a single summary score, but preference-based measures are often not administered in research studies. Many PROMIS investigators in the interest of parsimony elect to administer only the PROMIS-10 [ 5 – 7 ]. Being able to estimate the PROPr from the PROMIS global health items and scales provides an option for estimating a single summary score when a separate preference-based measure has not been administered.…”

Section: Introductionmentioning

confidence: 99%

Mapping of the PROMIS global health measure to the PROPr in the United States

Hays,

Herman,

Qureshi

et al. 2024

J Patient Rep Outcomes

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Background The Patient-Reported Outcomes Measurement and Information System (PROMIS®) global health items (global-10) yield physical and mental health scale scores and the PROMIS-Preference (PROPr) scoring system estimated from PROMIS domain scores (e.g., PROMIS-29 + 2) produces a single score anchored by 0 (dead or as bad as being dead) to 1 (full health). A link between the PROMIS global-10 and the PROPr is needed. Methods The PROMIS-29 + 2 and the PROMIS global-10 were administered to 4102 adults in the Ipsos KnowledgePanel in 2022. The median age was 52 (range 18–94), 50% were female, 70% were non-Hispanic White, and 64% were married or living with a partner. The highest level of education completed for 26% of the sample was a high school degree or general education diploma and 44% worked full-time. We estimated correlations of the PROPr with the PROMIS global health items and the global physical and mental health scales. We examined the adjusted R2 and estimated correlations between predicted and observed PROPr scores. Results Product-moment correlations between the PROMIS global health items and the PROPr ranged from 0.50 to 0.63. The PROMIS global physical health and mental health scale scores correlated 0.74 and 0.60, respectively, with the PROPr. The adjusted R2 in the regression of the PROPr on the PROMIS global health items was 64%. The equated PROPr preference scores correlated (product-moment) 0.80 (n = 4043; p < 0.0001) with the observed PROPr preference scores, and the intra-class correlation (two-way random effects model) was 0.80. The normalized mean absolute error (NMAE) was 0.45 (SD = 0.43). The adjusted R2 in the OLS regression of the PROPr on the PROMIS global health scales was 59%. The equated PROPr preference scores correlated (product-moment) was 0.77 (n = 4046; p < 0.0001) with the observed PROPr preference scores, and the intra-class correlation was 0.77. The NMAE was 0.49 (SD = 0.45). Conclusions Regression equations provide a reasonably accurate estimate of the PROPr preference-based score from the PROMIS global health items or scales for group-level comparisons. These estimates facilitate cost-effectiveness research and meta-analyses. The estimated PROPr scores are not accurate enough for individual-level applications. Future evaluations of the prediction equations are needed.

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Section: Introductionmentioning

confidence: 99%

Mapping of the PROMIS global health measure to the PROPr in the United States

Hays,

Herman,

Qureshi

et al. 2024

J Patient Rep Outcomes

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Association of unmet basic resource needs with frailty and quality of life among older adults with cancer—Results from the CARE registry

et al. 2023

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Background Basic resource needs related to transportation, housing, food, and medications are important social determinants of health and modifiable indicators of poverty, but their role in modifying the risk of frailty and health‐related quality of life (HRQoL) remains unknown. The goal of our study was to examine the prevalence of unmet basic needs and their association with frailty and HRQoL in a cohort of older adults with cancer. Methods The CARE registry prospectively enrolls older adults (≥60 years) with cancer. Assessments of transportation, housing, and material hardship were added to the CARE tool in 8/2020. The 44‐item CARE Frailty Index was used to define frailty, and subdomains of physical and mental HRQoL were assessed using the PROMIS® 10‐global. Multivariable analysis examined the association between unmet needs with frailty and HRQoL subdomains, adjusting for covariates. Results The cohort included 494 participants. Median age of 69 years, 63.6% were male and 20.2% were Non‐Hispanic (NH) Black. Unmet basic needs were reported in 17.8% (transportation 11.5%, housing 2.8%, and material hardship 7.5%). Those with unmet needs were more often NH Black (33.0% vs. 17.8%, p = 0.006) and less educated (

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The association between social vulnerability and geriatric assessment impairments among older adults with gastrointestinal cancers—The CARE Registry

Fowler,

Harmon,

Tucker

et al. 2024

Cancer

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BackgroundOlder adults comprise the majority of patients with gastrointestinal (GI) cancer. Geriatric assessments (GAs) are recommended for older adults with cancer in part to detect aging‐related impairments (e.g., frailty) associated with early mortality. Social factors like social vulnerability may also influence aging‐related impairments. However, the association between social vulnerability and aging outcomes among older adults with cancer is understudied.MethodsThe authors included 908 older adults aged 60 years and older who were recently diagnosed with GI cancer undergoing GA at their first prechemotherapy visit to the University of Alabama at Birmingham oncology clinic. The primary exposure of interest was the social vulnerability index (SVI). Outcomes were frailty (frail vs. robust/prefrail) and total number of GA impairments (range, 0–13). The authors examined the association between SVI and outcomes using Poisson regression with robust variance estimation and generalized estimating equations.ResultsThe median age at GA was 69 years (interquartile range, 64–75 years), 58.2% of patients were male, 22.6% were non‐Hispanic Black, 29.1% had colorectal cancer, 28.2% had pancreatic cancer, and 70.3% had stage III/IV disease. Adjusting for age, sex, cancer type, and disease stage, each decile increase in the SVI was associated with an 8% higher prevalence of frailty (prevalence ratio, 1.08; 95% confidence interval, 1.05–1.11) and a 4% higher average count of total GA impairments (risk ratio, 1.04; 95% confidence interval, 1.02–1.06). The results were attenuated after further adjustment for race and education.ConclusionsGreater social vulnerability was associated with a higher prevalence of frailty and an increasing average number of GA impairments among older adults with GI cancers before systemic treatment. Intervening on social vulnerability may be a target for improving the risk of frailty and GA impairments, but associations of race and education should be further evaluated.

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Association of unmet basic resource needs with frailty and quality of life among older adults with cancer—Results from the CARE registry

Cited by 5 publications

References 48 publications

Mapping of the PROMIS global health measure to the PROPr in the United States

Mapping of the PROMIS global health measure to the PROPr in the United States

Association of unmet basic resource needs with frailty and quality of life among older adults with cancer—Results from the CARE registry

The association between social vulnerability and geriatric assessment impairments among older adults with gastrointestinal cancers—The CARE Registry

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