The relationship between exposure to a single heavy metal and liver function has been reported. However, the effect of strontium exposure on liver function has not been examined. A cross-sectional study involving 1,021 residents from a mining area in Hunan Province, China, was conducted to explore the single and combined effects of strontium exposure on liver function. Liver function was determined by detecting the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBIL) in the serum. The plasma concentrations of strontium (Sr), lead (Pb), cadmium (Cd), manganese (Mn), Zinc (Zn), and copper (Cu) in residents were measured using inductively coupled plasma-mass spectrometry (ICP-MS). The sociodemographic characteristics, lifestyle factors, and history of disease were assessed by questionnaire. Then the association between plasma Sr and liver function was analyzed by multiple linear regression and BKMR.