Association of Tumor Size, Location, R.E.N.A.L., PADUA and Centrality Index Score with Perioperative Outcomes and Postoperative Renal Function

Bylund, Jason; Gayheart, Dustin; Fleming, Tyler; Venkatesh, Ramakrishna; Preston, David; Strup, Stephen E.; Crispen, Paul L.

doi:10.1016/j.juro.2012.07.043

Cited by 79 publications

(94 citation statements)

References 22 publications

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“…Unfortunately, some previous reports have shown that the C index, PADUA and R.E.N.A.L. nephrometry score cannot predict postoperative RFL, 10,12,13 although a few previous studies have shown that all three scoring systems are significantly associated with the percentage change in creatinine level, 14,15 as well as warm ischemia time and tumour size. 14 Therefore, in the present study, we developed a highly accurate index to predict the postoperative RFL following LPN.…”

Section: Discussionmentioning

confidence: 93%

“…Some anatomical scoring systems were reported to be able to predict the technical difficulty of LPN, 10 including the risk of surgical complications 8,11 and ischemia time 12 during LPN. The present study indicated that the m-CI might predict the operative time and ischemia time of LPN and blood loss during LPN, which should represent the surgical difficulty of LPN.…”

Section: Discussionmentioning

confidence: 99%

“…These systems allow for comparisons of data between reports and have become almost a standard requirement for clinical studies on renal tumours. In addition, recent studies have indicated that these anatomical scoring systems can predict the technical difficulty of LPN, 10 the risk of surgical perioperative complications, 8,11 and ischemia time 12 during LPN on the basis of renal anatomical characteristics. So far, several studies have validated the accuracy of these anatomical scores in predicting postoperative RFL; however, the ability of these scoring systems to predict postoperative RFL is still controversial.…”

Section: Introductionmentioning

confidence: 99%

“…So far, several studies have validated the accuracy of these anatomical scores in predicting postoperative RFL; however, the ability of these scoring systems to predict postoperative RFL is still controversial. 10,[12][13][14][15] Some previous studies have indicated that these scoring systems fail to predict RFL after LPN 10,12,13 and that there are few indices designed to predict RFL after LPN. Accurate prediction of RFL after LPN is crucial when choosing the optimal treatment for renal tumours and minimizing RFL during LPN.…”

Section: Introductionmentioning

confidence: 99%

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Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

Ito

Makiyama

Kawahara

et al. 2017

CUAJ

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Introduction: We aimed to develop a scoring system to quantify the distance between the renal hilum and renal tumour, termed the modified C index (m-CI), and to predict renal functional loss (RFL) following laparoscopic partial nephrectomy (LPN). Methods: The m-CI was measured by using computed tomography in 113 patients who underwent LPN between May 2003 and June 2014. The RFL following LPN was calculated by examining the estimated glomerular filtration rate (eGFR) and radioisotope renography one year postoperatively. The Pythagorean theorem was used to calculate the distance from the tumour centre to the renal hilum. The distance was divided by the tumour radius to obtain the m-CI. The correlation between the m-CI and the postoperative RFL were evaluated using Pearson's coefficient values. Multivariate logistic regression models were used to assess the potential predictive factors of RFL following LPN. The correlation between the m-CI and the operative time, ischemia time, and blood loss during LPN were also evaluated by the unpaired t-test. Results: Pearson's coefficient values between the postoperative RFL and the m-CI and C index were 0.294 and 0.173, respectively. In the multivariate analysis, the resected volume (p=0.031) and m-CI (p=0.036) significantly correlated with the postoperative RFL following LPN. The operative time (p<0.001), ischemia time (p=0.028), and blood loss (p=0.047) during LPN was significantly longer and larger, respectively, in the group with shorter m-CI (≤4.5) than in the group with the longer m-CI (>4.5). Conclusions:The present study demonstrates that the m-CI can predict RFL following LPN, as well as the surgical difficulty.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

Ito

Makiyama

Kawahara

et al. 2017

CUAJ

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“…1 PADUA scores have been validated to predict warm ischemic time (WIT) and perioperative complications for open, laparoscopic, and robot-assisted partial nephrectomy (RAPN). [2][3][4][5][6] Functional outcome is an important parameter during the surgical planning of renal tumours. Numerous welldocumented variables have been associated with postoperative renal function.…”

Section: Introductionmentioning

confidence: 99%

The association between the anatomical features of renal tumours and the functional outcomes of robot-assisted partial nephrectomy

Lee

Cho

Jeon

et al. 2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(11-12):e810-4. http://dx.doi.org/10.5489/cuaj.1642 Published online November 24, 2014. AbstractIntroduction: We evaluated the the association between PADUA scores and postoperative renal function (after robot-assisted partial nephrectomy [RAPN]) and between PADUA scores and warm ischemic time (during RAPN). Methods: We reviewed the clinical records of 106 patients who underwent RAPN for a single localized renal tumour between April 2009 and June 2012. Postoperative renal function was evaluated using estimated glomerular filtration rate (eGFR) in 85 patients who were followed for at least 6 months. PADUA scores for renal tumours were calculated using contrast-enhanced computed tomography images, if needed, along with magnetic resonance images in some cases. Results: A PADUA score ≥10 and WIT ≥30 minutes were observed in 18 (17.0%) and 51 (48.1%) cases, respectively. PADUA scores were significantly correlated with WIT (p = 0.019) and percent change in eGFR at 6 months postoperatively (p = 0.005). PADUA score (continuous variable, odds ratio [OR] 1.694, p = 0.007) and the high-risk group (PADUA score ≥10) (OR 5.429; p = 0.020) were significantly associated with a WIT of ≥30 minutes by multivariate analysis. A 1-point increase in the PADUA score was associated with an eGFR decrease of >20% at 6 months after RAPN (OR 1.799; p = 0.076). In addition, a PADUA score ≥10, or high risk, (OR 13.965; p = 0.003) was an independent predictor of an eGFR decrease of >20% at 6 months after RAPN. Conclusions: The PADUA classification can reliably predict WIT and postoperative renal functional outcome after RAPN. Furthermore, the study suggests that anatomical aspects of renal tumours are associated with functional outcome after RAPN.

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Parallel comparison of R.E.N.A.L., PADUA, and C‐index scoring systems in predicting outcomes after partial nephrectomy: A systematic review and meta‐analysis

Sun

Zhang

et al. 2021

Cancer Medicine

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Association of Tumor Size, Location, R.E.N.A.L., PADUA and Centrality Index Score with Perioperative Outcomes and Postoperative Renal Function

Abstract: Each scoring system outperformed tumor size and location, and may be useful when describing the surgical complexity of renal tumors treated with partial nephrectomy.

Cited by 79 publications

References 22 publications

Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

The association between the anatomical features of renal tumours and the functional outcomes of robot-assisted partial nephrectomy

Parallel comparison of R.E.N.A.L., PADUA, and C‐index scoring systems in predicting outcomes after partial nephrectomy: A systematic review and meta‐analysis

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