Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

Abstract

ABSTRACT. We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database were searched for all case-control studies on the relationship between the TNF-α 308G/A polymorphism and susceptibility to urogenital cancer between January 1994 and January 2015. The pooled odds ratio with 95% confidence interval was calculated to assess the associations. A total of 16103 Association between TNF-α 308G/A and urogenital cancer risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16102-16112 (2015) 504 articles were found, 39 of which involved 11,613 cases and 12,542 controls that fulfilled the inclusion criteria. Overall, the TNF-α 308G/A polymorphism was significantly associated with the risk of urogenital cancer. In the subgroup analysis for different cancer types, significant associations were found in cervical cancer and urothelial carcinoma, while our metaanalysis indicated that there were no significant associations between the TNF-α 308G/A polymorphism and prostate, bladder, or renal cancers. When stratified by ethnicity, significant associations were observed in Caucasian populations, whereas no significant associations were found in African-Americans, Asians, or mixed populations. Furthermore, carriers of the -308A allele among the hospital-based case-control group were at a high risk of urogenital cancer. Our meta-analysis showed that the TNF-α 308G/A polymorphism was significantly associated with urogenital cancer risk, particularly in the Caucasian and hospital-based populations.

The ERCC1-4533/8092, TNF-α 238/308 polymorphisms and the risk of hepatocellular carcinoma in Guangxi Zhuang populations of China

“…[ 8 , 9 ] Several studies have indicated that several polymorphisms in the promoter region of TNF-α are associated with the risk of some types of cancers, such as urogenital cancer, non-Hodgkin lymphomas, gastric cancer, and breast cancer. [ 10 – 13 ]…”

Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies

“…According to the current meta-analysis, there was a variety in terms of s1799724 and rs1800629 polymorphisms of the TNF-α gene distribution in the different ethnicity. Compared to the previously published meta-analyses [24,25] there are more studies included in the current meta-analysis, and the overall sample size is larger; therefore, our findings are more precise and reliable. In addition, the present meta-analysis there is the only study that has assessed both s1799724 and rs1800629 polymorphisms association with cervical cancer simultaneously.…”

Association of TNF-α -308G>A Polymorphism with Susceptibility to Cervical Cancer and Breast Cancer – a Systematic Review and Meta-analysis

“…1). found that the TNF-α 308G>A polymorphism was significantly associated with CC risk [57]. Furthermore, in another meta-analysis Jin et al have found that -308 G>A and -238 G>A polymorphisms of TNF-α gene may confer susceptibility to CC in an ethnic-specific fashion [55].…”