Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

Zheng, Ruibing; Fu, Zhanli; Zhao, Zi-miao

doi:10.1089/gtmb.2020.0143

Cited by 6 publications

(8 citation statements)

References 39 publications

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“…A study carried out in China in patients with sepsis associated the rs1800469 polymorphism of the TGF-β1 gene to lower plasma levels of this cytokine and a reduced risk of susceptibility to sepsis. However, the same study observed that the rs1800468 polymorphism was associated with higher levels of TGF-β1 and greater susceptibility to sepsis (ZHENG, et al 2021), a result that is different from the result found in our study.…”

Section: Discussioncontrasting

confidence: 99%

“…in the lungs, which can release TGF-β1 into the blood of patients (Ghazavi et al, 2020). Zheng et al, in a study carried out in China with 285 patients with sepsis (119 patients with severe sepsis and 166 patients with mild sepsis) and 285 healthy individuals (control group) found plasma levels of TGF-β1 higher in patients with severe sepsis, indicating that the higher concentration of this cytokine contributes to the worsening of the condition (Zheng, Fu & Zhao, 2021).…”

Section: Discussionmentioning

confidence: 99%

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Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Carminati

Carneiro

Cunha

et al. 2022

RSD

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This study aimed to investigate the role of the TGF-β1 gene in SARS-CoV-2 infection. A total of 178 individuals diagnosed with Covid-19 participated and, they were divided in two groups related to the outcome (discharge or death). Genotyping of rs1800468 and rs1800469 polymorphisms of TGF-β1 gene was performed in 178 samples, using the allelic discrimination technique and, gene expression analysis was performed in 93 samples by Real Time PCR. There was no association between the genotypic frequencies of TGF-β1 gene polymorphisms analyzed with the prognosis of patients with Covid-19. There was no significant difference between gene expression and the clinical data evaluated. A statistically significant difference was observed in the expression of the TGF-β1 gene between the CT and TT genotypes of the rs1800469 polymorphism, with lower gene expression in the presence of the TT genotype. Regarding the rs1800468 polymorphism, no statistically significant difference was observed in the expression of the TGF-β1 gene in relation to the analyzed genotypes. The present study concluded that the rs1800468 and rs1800469 polymorphisms of the TGF-β1 gene are not associated with the prognosis of patients with Covid-19 and which the TT genotype of the rs1800469 polymorphism reduces the expression of TGF-β1.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Carminati

Carneiro

Cunha

et al. 2022

RSD

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“…Furthermore, Nabrdalik et al [ 32 ], showed that the minor C allele of rs1800471 was associated with the occurrence of chronic kidney disease, whereas the rs1800471 G allele was associated with the presence of hypertension [ 32 ]. Our results are consistent with previous studies that found an association between rs1800471 C > G and higher TGF-β1 levels and susceptibility to sepsis [ 33 ]. Consistent with these results, CTS patients carrying the minor C allele rs1800471 as either homozygotes CC or heterozygotes CG showed a significant increase in serum TGF-β1 levels compared with GG carriers.…”

Section: Discussionsupporting

confidence: 93%

“…Many studies have investigated the association of TGF1β-SNPs with various diseases [ 32 , 33 , 34 ], but these SNPs have not yet been studied in CTS patients. We hypothesized that the increase in serum TGF-β1 in CTS patients might be due to genetic variants.…”

Section: Discussionmentioning

confidence: 99%

Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome

Fattah

Selim²,

Fattah

et al. 2023

JPM

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Carpal tunnel syndrome (CTS) is a common entrapment neuropathy in which one of the body’s peripheral nerves becomes pinched or crushed. Transforming growth factor beta 1 (TGF-β1) plays an important role in the pathogenesis of CTS. An association between TGF-β1 polymorphisms and the susceptibility or progression of a number of diseases has been reported. In this study, three TGF-β1 single nucleotide polymorphisms (SNPs), serum TGF-β1, and macrophage inflammatory protein 1 beta (MIP-1β) were investigated as potential diagnostic markers for the progression of CTS in Egyptian patients. One hundred CTS patients and 100 healthy controls were recruited for the study. TGF-β1 SNPs +915G/C, −509C/T and −800G/A were determined by TaqMan genotyping assay. Serum TGF-β1 and MIP-1β levels were measured by ELISA. Serum TGF-β1 and MIP-1β levels increased significantly and were strongly correlated with the occurrence of CTS. The C allele of +915G/C, the T allele of −509C/T, and the G allele of −800G/A occurred more frequently in patients from CTS than in controls. The serum levels of TGF-β1 and MIP-1β in the group of carriers of the genotypes +915G/C GC and CC, the genotype −509C/T TT and the genotype −800G/A GA and AA were significantly higher in CTS patients. TGF-β1 and its +915G/C, −509C/T, and −800G/A SNPs and MIP-1β could be useful prognostic markers for the occurrence of CTS.

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“…Sepsis-induced ARDS patients displayed FASLG−FAS, which reportedly is related to increased protein permeability in the pulmonary alveoli [ 27 ], and CCL3/4/5−CCR1, which is related to the chemokines and proinflammatory cytokines that participate in and promote inflammatory responses related to macrophages [ 28 , 29 ]. Sepsis-only patients displayed IL1B−IL1RAP, of which Interleukin-1-B (IL1B) is a proinflammatory cytokine that plays an important role in sepsis and affects the p38 MAPK and NF κ B signaling pathways [ 30 , 31 ], and TGFB1−TGFBR1, of which transforming growth factor beta1 (TGF-beta1) gene single-nucleotide polymorphisms and plasma TGF-beta1 levels were thought to be associated with susceptibility to sepsis [ 32 ]. Furthermore, we analyzed the downstream TFs targeted by LR pairs ( Figure 3(c) ) and found that different TFs, including SMAD3, RBPJ, and MAX, were targeted in sepsis-only patients, while FOS, STAT3, STAT2, and RB1 were targeted in sepsis-induced patients.…”

Section: Resultsmentioning

confidence: 99%

Investigating the Intercellular Communication Network of Immune Cell in Acute Respiratory Distress Syndrome with Sepsis

Tao

et al. 2022

Computational and Mathematical Methods in Medicine

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Acute respiratory distress syndrome (ARDS) is recognized as a serious public health issue that results in respiratory failure and high mortality rates. The syndrome is characterized by immune cell aggregation, communication, activation, and alveolar epithelial damage. To elucidate the complex dynamic process of the immune system’s response in ARDS, we construct the intercellular communication network of immune cells in ARDS based on a single-cell RNA sequencing dataset (including three sepsis-induced ARDS patients and four sepsis-only patients). The results show that macrophages relayed most of the intercellular signals (ligand–receptor pairs) in both groups. Many genes related to immune response (IFI44L, ISG, and HLA-DQB1) and biological functions (response to virus, negative regulation of viral life cycle, and response to interferon-beta) were detected via differentially expressed gene analysis of macrophages between the two groups. Deep analysis of the intercellular signals related to the macrophage found that sepsis-induced ARDS harbored distinctive intercellular signals related to chemokine–chemokine receptors (CCL3/4/5−CCR1), which mainly are involved in the disturbance of the STAT family transcription factors (TFs), such as STAT2 and STAT3. These signals and downstream TFs might play key roles in macrophage M1/M2 polarization in the process of sepsis-induced ARDS. This study provides a comprehensive view of the intercellular communication landscape between sepsis and sepsis-induced ARDS and identifies key intercellular communications and TFs involved in sepsis-induced ARDS. We believe that our study provides valuable clues for understanding the immune response mechanisms of ARDS.

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Association of Transforming Growth Factor β1 Gene Polymorphisms and Inflammatory Factor Levels with Susceptibility to Sepsis

Cited by 6 publications

References 39 publications

Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Relation of TGF-β1 gene with the prognosis of patients with Covid-19

Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome

Investigating the Intercellular Communication Network of Immune Cell in Acute Respiratory Distress Syndrome with Sepsis

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