Association of TNF-α polymorphism with susceptibility to and severity of non-small cell lung cancer

Tumor Necrosis Factor-α Gene Polymorphisms and Risk of Oral Cancer: Evidence from a Meta-analysis

“…Commonly described variants of TNF-α gene polymorphisms consist of G to A transitions in the promoter region at positions _238 and _308 (Kaluza et al, 2000). So far, TNF-α promoter polymorphism has been related to numerous cancers, such as bladder cancer (Marsh et al, 2003), renal cell carcinoma (Nakajima et al, 2001), non-small cell lung carcinoma (Shih et al, 2006) cervical cancer (Govan et al, 2006;Liu et al, 2012b) and breast carcinoma (Mestiri et al, 2001).…”

Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

“…Accordingly, it is rational to speculate that TNF-α -308G>A and -238G>A polymorphisms may have an impact on the development of some types of cancers. In recent years, numerous casecontrol studies have been conducted to investigate the associations of TNF-α -308G>A and -238G>A promoter region polymorphisms with cancer risk, suggesting that these polymorphisms may be associated with cancer susceptibility, such as breast cancer, lung cancer, nasopharyngeal cancer and cervical cancer (Deshpande et al, 2005;Shih et al, 2006;Pooja et al, 2011;Sousa et al, 2011).…”

The Lymphotoxin-α 252 A>G Polymorphism and Breast Cancer: A Meta-analysis

“…On one hand, cancer is a multi-factorial disease with complex interactions of environmental and genetic factors (Shih et al, 2006). Environmental factors may play a key role in cancer development, for example physical activity, food selection, infection and carcinogens exposure.…”