Association of TNF-α Gene Promoter Polymorphisms With Susceptibility of Cervical Cancer in Southwest China

Zuo, Fengqiong; Liang, Weibo; Ouyang, Yunwei; Li, Wanyi; Lv, Meili; Wang, Guoyu; Ding, Mingpu; Wang, Baoning; Zhao, Shilei; Liu, Jin; Jiang, Zhonghua; Li, Mingyuan

doi:10.1309/lm532dspduxirjvn

Cited by 11 publications

(8 citation statements)

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“…In our meta-analysis, a significant association was found between the TNF-α 308G/A polymorphism and urogenital cancer risk, indicating that the -308A allele might be a genetic risk factor for susceptibility to urogenital cancer. In the subgroup analysis of cancer type, our study suggested that the TNF-α 308G/A polymorphism led to an increased incidence of cervical cancer risk in the allele contrast model (OR = 1.28, 95%CI = 1.08-1.52, P = 0.004), the heterozygote model (OR = 1.27, 95%CI = 1.02-1.60, P = 0.034), and the dominant model (OR = 1.29, 95%CI = 1.06-1.58, P = 0.013), which was consistent with several of the studies we included (Duarte et al, 2005;Kohaar et al, 2007;Singh, 2009;Zuo et al, 2011;Badano et al, 2012;Sousa et al, 2014), but not with some of the other studies (Jang et al, 2001;Calhoun et al, 2002;Gostout et al, 2003;Deshpande et al, 2005;Ivansson, 2010;Wang et al, 2011;Barbisan et al, 2012;Wang et al, 2012). Furthermore, previous meta-analyses have produced the same conclusion.…”

Section: Discussionsupporting

confidence: 86%

“…The TNF-α 308G/A polymorphism is a G/A polymorphism at nucleotide (nt) -308, and is associated with the development of several urogenital cancers, including prostate cancer (Zabaleta et al, 2008;Moore et al, 2009;Jones et al, 2013), cervical cancer (Singh, 2009;Zuo et al, 2011), bladder cancer (Jeong et al, 2004;Kim et al, 2005;Leibovici et al, 2005), and renal cell carcinoma (Jang et al, 2001). For example, Jeong et al (2004) studied 113 patients with bladder cancer and 109 healthy subjects and found that the genotype of the 308 nucleotide in the TNF-α promoter had a statistically significant effect on TNF-α production and was related to the bladder tumor grade.…”

Section: Discussionmentioning

confidence: 99%

“…There are 13 studies (Oh et al, 2000;McCarron et al, 2002;Wu, 2004;Jinchao, 2007;Danforth et al, 2008;Sáenz-López et al, 2008;Zabaleta et al, 2008;Kesarwani, 2009;Moore et al, 2009;Wang et al, 2009a;Zhang et al, 2010;Berhane et al, 2012;Jones et al, 2013) focusing on prostate cancer, 19 studies (Jang et al, 2001;Calhoun et al, 2002;Gostout et al, 2003;Stanczuk et al, 2003;Deshpande et al, 2005;Duarte et al, 2005;Govan, 2006;Kohaar et al, 2007;Singh, 2009;Wang et al, 2009b;Ivansson, 2010;Zu, 2010;Wang et al, 2011;Zuo et al, 2011;Badano et al, 2012;Barbisan et al, 2012;Hang and Xu, 2012;Wang et al, 2012;Sousa et al, 2014) on cervical cancer, 6 studies (Tsai et al, 2001;Jeong et al, 2004;Kim et al, 2005;Leibovici et al, 2005;Nonomura et al, 2006;Ahirwar et al, 2008) on bladder cancer, 1 study (Jang et al, 2001) on renal cell cancer, and 1 study (Wu, 2013) on urothelial carcinoma. Five articles (Stanczuk et al, 2003;…”

Section: Study Characteristicsmentioning

confidence: 99%

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Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

et al. 2015

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ABSTRACT. We integrated all the eligible studies and investigated whether the TNF-α 308G/A polymorphism correlates with urogenital cancer risk. Tumor necrosis factor-α (TNF-α) is a risk factor for some urogenital cancers; however, in prostate and bladder cancers the results are controversial. PubMed, EMBASE, Web of Science, the Cochrane Library, the Chinese Biomedical Literature Database, and the Wanfang Database were searched for all case-control studies on the relationship between the TNF-α 308G/A polymorphism and susceptibility to urogenital cancer between January 1994 and January 2015. The pooled odds ratio with 95% confidence interval was calculated to assess the associations. A total of 16103 Association between TNF-α 308G/A and urogenital cancer risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16102-16112 (2015) 504 articles were found, 39 of which involved 11,613 cases and 12,542 controls that fulfilled the inclusion criteria. Overall, the TNF-α 308G/A polymorphism was significantly associated with the risk of urogenital cancer. In the subgroup analysis for different cancer types, significant associations were found in cervical cancer and urothelial carcinoma, while our metaanalysis indicated that there were no significant associations between the TNF-α 308G/A polymorphism and prostate, bladder, or renal cancers. When stratified by ethnicity, significant associations were observed in Caucasian populations, whereas no significant associations were found in African-Americans, Asians, or mixed populations. Furthermore, carriers of the -308A allele among the hospital-based case-control group were at a high risk of urogenital cancer. Our meta-analysis showed that the TNF-α 308G/A polymorphism was significantly associated with urogenital cancer risk, particularly in the Caucasian and hospital-based populations.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

et al. 2015

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“…They are mainly secreted by activated macrophages and are able to promote the host's defense mechanism by activating inflammatory processes (8). Although a moderate TNF level is necessary to maintain cell protected and prevent certain diseases through regulation of the immune response, excessive TNF secretion due to pathological conditions is associated with autoimmune diseases, infectious diseases and malignant tumors (9). In cervical cancer, TNF promotes cell cycle progression by increasing cyclin-dependent kinase activity and HPV16 E6/E7 RNA expression in HPV-immortalized keratinocytes (9, 10).…”

Section: Introductionmentioning

confidence: 99%

“…Although a moderate TNF level is necessary to maintain cell protected and prevent certain diseases through regulation of the immune response, excessive TNF secretion due to pathological conditions is associated with autoimmune diseases, infectious diseases and malignant tumors (9). In cervical cancer, TNF promotes cell cycle progression by increasing cyclin-dependent kinase activity and HPV16 E6/E7 RNA expression in HPV-immortalized keratinocytes (9, 10). It also enhances the transcription and stability of epidermal growth factor receptor (EGFR), resulting in cell proliferation and tumorigenesis (9, 11).…”

Section: Introductionmentioning

confidence: 99%

Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

Matos

Cândido

Vidigal

et al. 2016

Tumori

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Introduction The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inﬂammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions. Methods A total of 64 embedded tissues were obtained from gynecological procedures, including 35 specimens with cervical intraepithelial neoplasia (CIN) and 10 specimens with cervical squamous cell carcinoma (CSCC) as well as 19 normal cervical samples. The expression of TLR2, TLR3, TLR4, TNF-α and TNF-β was measured by immunohistochemistry and graded into low and high levels of expression. Results There was an association between the expression levels of TLR2 and those of TNF-α and TNF-β (p = 0.01 and p = 0.021, respectively) in the cervical cancer and CIN groups. TLR4 expression was associated with TNF-α and TNF-β expression (p = 0.016 and p = 0.025, respectively) in these 2 groups. By contrast, TLR3 was not statistically associated with TNF-α or TNF-β in any of the groups. Conclusions There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer. These markers are also expressed at higher levels in cervical cancer and premalignant lesions compared to normal controls.

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RETRACTED ARTICLE: Impact of Toll-Like Receptors 2/3/4/9, IL-1-α/β and TNF-α Polymorphisms in Cervical Cancer Susceptibility in Tunisia

Zidi

Verdı²,

Yilmaz-Yalcin³

et al. 2014

Pathol. Oncol. Res.

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Association of TNF-α Gene Promoter Polymorphisms With Susceptibility of Cervical Cancer in Southwest China

Cited by 11 publications

References 28 publications

Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

Association of tumor necrosis factor-α 308G/A polymorphism with urogenital cancer risk: a systematic review and meta-analysis

Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

RETRACTED ARTICLE: Impact of Toll-Like Receptors 2/3/4/9, IL-1-α/β and TNF-α Polymorphisms in Cervical Cancer Susceptibility in Tunisia

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