Association of TLR4 Polymorphisms, Expression, and Vitamin D with Helicobacter pylori Infection

Assaad, Shafika; Costanian, Christy; Jaffal, Lama; Tannous, Fida; Stathopoulou, Maria G.; Shamieh, Said El

doi:10.3390/jpm9010002

Cited by 17 publications

(14 citation statements)

References 29 publications

(38 reference statements)

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“…Our search identified 182 related references, of which 10 papers met our inclusion criteria . The flowchart describing the process of study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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Background Various studies reported the relationship between Helicobacter pylori (H pylori) and vitamin D, but there is some controversy around that. This study aimed to conduct a meta‐analysis to clarify the relationship between vitamin D and H pylori infection, and vitamin D and H pylori eradication. Methods Articles published until June 1, 2019, in the PubMed, MEDLINE, and EMBASE databases with English‐language medical studies were searched. According to the inclusion criteria, relevant statistical data were extracted to Microsoft Excel and analyzed by STATA15.1. Results Ten articles were finally included. It was demonstrated that average 25(OH)D level in H pylori‐positive patients was lower than H pylori‐negative (SMD = −0.53 ng/mL, 95% CI = (−0.91, −0.16 ng/mL)). For H pylori eradication individuals, the result showed that average 25(OH)D level in H pylori successful eradication individuals was higher than unsuccessful (SMD = 1.31 ng/mL, 95% CI = [0.60, 2.02 ng/mL]). In addition, individuals with vitamin D deficiency had lower H pylori eradicate rate (OR = 0.09, 95% CI = [0.02, 0.41]). Sensitivity analysis showed that the meta‐analysis results were stable and reliable. Conclusions Vitamin D was a protective factor to H pylori infection. Moreover, vitamin D can improve the success rate of H pylori eradication.

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“…Our search identified 182 related references, of which 10 papers met our inclusion criteria . The flowchart describing the process of study selection is shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Yang

et al. 2019

Helicobacter

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“…Participants involved in the present study were recruited in accordance with the latest version of the Declaration of Helsinki for Ethical Principles for Medical Research Involving Human Subjects as described previously [13]. Protocols for the genetic studies were approved by the local ethics committees for the protection of subjects for biomedical research.…”

Section: Methodsmentioning

confidence: 99%

Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome

Salami

Shamieh

2019

Medicina

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Background and Objectives: Four single nucleotide polymorphisms (SNPs); rs6921438 and rs4416670 in LOC100132354-C6orf223, rs6993770 in ZFPM2, and rs10738760 in VLDLR-KCNV2 were reported to explain up to 50% of the heritability of vascular endothelial growth factor circulating levels. These SNPs were also studied for possible associations with circulating lipid levels in supposedly healthy European individuals and in a limited number of Iranian individuals with metabolic syndrome. To go further, the association of those four SNPs with plasma lipid parameters, hypercholesterolemia and metabolic syndrome (MetS) was assessed. Materials and Methods: A cross-sectional study was conducted on 460 individuals chosen from the general population. Demographic and clinical data were collected and DNA was extracted and genotyped using Kompetitive allele specific PCR (KASP™). A meta-analysis followed, combining our participants with the Iranian individuals (n = 336). Results: Whereas rs10738760 was associated with total cholesterol (Tchol) (p = 0.01), rs6993770 showed significant associations with both Tchol and low-density lipoprotein cholesterol (LDL-C) levels (p = 0.007 and p = 0.01 respectively). Using a multivariate logistic regression model adjusted for different confounding factors, we found that rs6993770 was associated with hypercholesterolemia, specifically high Tchol (p = 0.01) and LDL-C levels (p = 0.01). Furthermore, rs10738760 was positively associated with the risk of MetS in these individuals (p = 0.02) and in the meta-analysis (OR = 1.67, p = 0.01). Conclusion: Our results suggest that whereas rs6993770 in ZFPM2 was positively associated with hypercholesterolemia, rs10738760 (VLDLR-KCNV2) has a possible implication in MetS in two Middle Eastern populations.

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“…All measurements, including demographic, clinical, and biochemical measurements, were assessed as described previously [11]. Nuclear DNA was extracted from whole-blood samples according to the manufacturer's recommendations (QIAamp DNA blood mini kit, Qiagen, Hilden, Germany).…”

Section: Clinical and Biological Data Collectionmentioning

confidence: 99%

rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report

Salami

Costanian

Shamieh

2019

JCDD

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Many studies have assessed the implication of cluster of differentiation 14 (CD14) molecules and its single nucleotide polymorphism rs2569190A>G with different complex diseases, such as diabetes and cardiovascular diseases (CVDs). In this study, we investigated the association of rs2569190A>G in CD14 with cardiovascular disease risk factors (hypercholesterolemia and hypertension) in 460 individuals from the general Lebanese population (Middle Eastern multiethnic population). Using a multiple logistic regression model adjusted for six covariates (under additive and recessive assumptions), we found that the G allele of rs2569190 in CD14 was associated with increased levels of total cholesterol (OR = 3.10, p = 0.009), low-density lipoprotein cholesterol (OR = 3.87, p = 0.003), and decreased levels of high-density lipoprotein cholesterol (OR = 0.38, p = 0.001). In contrast, no significant relationship was found with hypertension. Thus, we concluded that rs2569190G in CD14 is associated with a higher risk of developing hypercholesterolemia.

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Association of TLR4 Polymorphisms, Expression, and Vitamin D with Helicobacter pylori Infection

Cited by 17 publications

References 29 publications

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Effect of vitamin D on Helicobacter pylori infection and eradication: A meta‐analysis

Association between SNPs of Circulating Vascular Endothelial Growth Factor Levels, Hypercholesterolemia and Metabolic Syndrome

rs2569190A>G in CD14 is Independently Associated with Hypercholesterolemia: A Brief Report

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