Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

Abstract

Background. Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent. Therefore, we included all eligible studies in our study for further meta-analysis. Methods. We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020. Selecting studies involved case-control trials. For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data. The size of the combined effect was calculated using STATA 15.0. Results. Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects. Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs. G allele: p=0.014, OR=1.208, 95% CI: 1.039-1.406), recessive model (GG vs. GA+AA: p=0.028, OR=0.755, 95% CI: 0.588-0.970), and codominant model (GG VS. AA: p=0.014, OR=0.681, 95% CI: 0.501-0.925). In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs. A allele: p=0.017, OR=12.064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p=0.016, OR=0.08, 95% CI: 0.010-0.620), and codominant model (GA VS. GG: p=0.016, OR=1.026, 95% CI: 0.821-1.282). Conclusion. The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis. In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease

“…Recently, case-control studies on the significance of the SNP rs5743708 in the TLR2 gene in periodontitis were summarized in a meta-analysis [ 20 ]. In this analysis, no association of this SNP and periodontitis, including disease-specific subgroup analysis (aggressive, chronic periodontitis), was confirmed.…”

“…Due to their functional consequences, all described SNPs are highly involved in the immune response and could thus represent a possible link between periodontal and cardiovascular diseases. And indeed, in a variety of case-control studies as well as in meta-analyses, their impact on periodontitis as well as CV diseases was assessed (CD14 [15][16][17], NF-κΒ [14,18,19], TLR2 [20,21], and TLR4 [4,22,23]).…”

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

“…In early studies, candidate genes involved in host immunity, inflammation, and tissue remodeling were selected as targets, and their single nucleotide polymorphisms (SNPs) were associated with periodontitis. A number of candidate gene studies showed that IL1A, IL1B, IL4, IL6, IL10, TNFA, FcγR, VDR, TLR2, TLR4, and MMP1 [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ] were the main genes associated with periodontal disease. In particular, the IL-1 gene cluster has been analyzed since the early days of studies on periodontal genetics, and SNPs in the IL-1 genes were proposed to be used for genotyping periodontal patients [ 70 , 71 , 72 , 73 ].…”

Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1

“…Previous studies demonstrated that TLR1 (rs5743618) and TLR6 (rs5743810) single‐nucleotide polymorphisms (SNPs) associate with the colonization of a known periodontal pathogen Treponema denticola (Mehlotra et al, 2016), while TLR2 (rs5743708) polymorphism is connected to risk of developing periodontitis (Shan et al, 2020). To date, however, salivary hBD or HNP concentrations in relation to TLR1 , TLR2 , and TLR6 gene polymorphisms have not been examined.…”