Association of the triglycerides to high-density lipoprotein cholesterol ratio with the risk of chronic kidney disease: Analysis in a large Japanese population

Tsuruya, Kazuhiko; Yoshida, Haruhiko; Nagata, Michio; Kitazono, Takanari; Hirakata, Hideki; Iseki, Kunitoshi; Moriyama, Toshiki; Yamagata, Kunihiro; Yoshida, Hiroyuki; Fujimoto, Shouichi; Asahi, Koichi; Kurahashi, Issei; Ohashi, Yasuo; Watanabe, Tsuyoshi

doi:10.1016/j.atherosclerosis.2013.12.037

Cited by 71 publications

(60 citation statements)

References 30 publications

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“…Previous investigations have shown that higher TG/HDL-c is independently correlated with coronary heart disease [10, 39] and all-cause mortality [40]. Several cross-sectional [41] and longitudinal studies [42, 43] have also shown a relationship between TG/HDL-c and CKD. In the present analysis, we were able to reproduce this finding utilizing the new CKD-EPI equation.…”

Section: Discussionmentioning

confidence: 95%

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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Background/Aims: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. Methods: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m² or dipstick-positive proteinuria. Logistic regression models were used to examine the relationship between lipid variables and CKD. Results: The prevalence of CKD in this study was 3.7%. When the participants exhibited higher serum triglyceride (TG), a higher TG/high-density lipoprotein cholesterol (TG/HDL-c) ratio or a higher non-HDL-c/HDL-c ratio or HDL-c in a lower quartile, the prevalence of CKD tended to be higher. The multivariate adjusted odds ratios for CKD per 1 standard deviation increase in lipid level were 1.17 (1.10-1.23) for TG, 0.86 (0.79-0.93) for HDL-c, 1.21 (1.13-1.31) for the TG/HDL-c ratio, and 1.14 (1.06-1.22) for the non-HDL-c/HDL-c ratio. No significant association was detected between CKD and total cholesterol (TC), non-HDL-c or the low-density lipoprotein cholesterol/HDL-c (LDL-c/HDL-c) ratio. Conclusion: In this relatively healthy adult Chinese population, the CKD-EPI equation determined that the TG/HDL-c and non-HDL-c/HDL-c ratios as well as TG and HDL-c correlate with the prevalence of CKD.

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Section: Discussionmentioning

confidence: 95%

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Wen

Chen

Huang

et al. 2017

Kidney Blood Press Res

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show abstract

“…1 ROC curve of the TG/HDL-C ratios and non-HDL-C levels as predictors of the outcomes. The TG/HDL-C ratio exhibited a similar predictive performance for cardiovascular events and all-cause mortality subgroups by adding a multiplicative interaction term in our statistical model as previously described [24]. The survival analysis was based on the Kaplan-Meier curve with subjects censored for death.…”

Section: Discussionmentioning

confidence: 99%

Triglyceride to high-density lipoprotein cholesterol ratio predicts cardiovascular events in maintenance hemodialysis patients

Hasegawa¹,

Kojima²,

Ueda³

et al. 2016

Ren Replace Ther

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Background: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been shown to be a predictor of cardiovascular (CV) outcomes in the general population. The aim of this study was to determine whether the TG/HDL-C ratio is a predictor of CV events and all-cause mortality in maintenance hemodialysis (MHD) patients. Methods: We performed a retrospective, observational cohort study in which we enrolled 193 MHD patients from a single center in Japan who had been followed up for a median of 3.9 years. The outcomes were the occurrence of a CV event and all-cause mortality during the follow-up period. Baseline TG/HDL-C ratios were investigated for associations with outcomes by using Cox regression models adjusted for demographic parameters. Results: Overall, 88 of the subjects experienced a CV event, and 32 patients had died, of whom 4 died due to CV events. Patients with higher TG/HDL-C levels (tertile 3) had a higher incidence of CV events (adjusted hazard ratio [HR] 1.82, 95 % confidence interval [CI] 1.01-3.35) and higher all-cause mortality (adjusted HR 6.13, 95 % CI 2.13-20.22) than the patients in tertile 1. Kaplan-Meier analyses by the log-rank test showed that the TG/HDL-C ratio had significant predictive power for detecting a CV event.Conclusions: The TG/HDL-C ratio is a reliable and easily accessible marker for predicting CV events and mortality in MHD patients.

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“…It has been suggested that uremia causes these changes, directly or indirectly through related metabolic processes such as inflammation, which leads to decreased metabolism of triglyceride-rich VLDL particles by adipose tissue, decreased clearance of IDL remnants by the liver, and metabolism of LDL to small, dense particles. Patients with CKD frequently have mixed dyslipidemia [13,16]. In the setting of mild to moderate impairment of kidney function, similar patterns of abnormalities may be present [17].…”

Section: Discussionmentioning

confidence: 96%

“…The main outcome of interest was new-onset CKD, which was defined as an eGFR < 60 mL/min/1.73 m 2 (low eGFR) and/or the presence of proteinuria [13]. The estimated glomerular filtration rate (eGFR) was calculated using the following equation: eGFR (mL/min/1.73 m 2 ) = 175 × serum creatinine (mg/dL) -1.234 × age (years) -0.179 [if female, × 0.79].…”

Section: Measurements and Outcomesmentioning

confidence: 99%

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

Zuo¹,

Chen²,

Liu

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

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Association of the triglycerides to high-density lipoprotein cholesterol ratio with the risk of chronic kidney disease: Analysis in a large Japanese population

Cited by 71 publications

References 30 publications

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Association of the TG/HDL-C and Non-HDL-C/HDL-C Ratios with Chronic Kidney Disease in an Adult Chinese Population

Triglyceride to high-density lipoprotein cholesterol ratio predicts cardiovascular events in maintenance hemodialysis patients

Non-HDL-cholesterol to HDL-cholesterol ratio as an independent risk factor for the development of chronic kidney disease

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