Association of the TRIB1 tribbles homolog 1 gene rs17321515 A&gt;G polymorphism and serum lipid levels in the Mulao and Han populations

Aung, Lynn Htet Htet; Yin, Rong; Wu, Dong‐Feng; Li, Qing; Yan, Tingting; Wang, Yiming; Li, Hui; Wei, Dai-Xun; Shi, Yuan-Lu; Dezhai, Yang

doi:10.1186/1476-511x-10-230

Cited by 23 publications

(33 citation statements)

References 44 publications

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“…All determinations were performed with an autoanalyzer (Type 7170A; Hitachi Ltd., Tokyo, Japan) in the Clinical Science Experiment Center of the First Affiliated Hospital, Guangxi Medical University. The normal values of serum TC, TG, HDL-C, LDL-C, ApoA1 and ApoB levels and the ratio of ApoA1 to ApoB in our Clinical Science Experiment Center were 3.10–5.17, 0.56–1.70, 1.16–1.42, 2.70–3.10 mmol/L, 1.20–1.60, 0.80–1.05 g/L and 1.00–2.50, respectively2122.…”

Section: Methodsmentioning

confidence: 81%

“…It has been noted that the genotype and allele frequencies of several SNPs are not consistent among different populations8919202122. The G allele frequency of MLXIPL rs3812316 (Q241H) SNP was 0.05 in Mexicans41, 0.10 in Europeans18 and 0.09 in Indian Asians18 and Japanese individuals23.…”

Section: Discussionmentioning

confidence: 99%

“…The consent procedure was also approved by the Ethics Committee of the First Affiliated Hospital, Guangxi Medical University. An incentive of approximately ten dollars was provided to each participant in the study19202122.…”

Section: Methodsmentioning

confidence: 99%

“…Genomic DNA was isolated from peripheral blood leukocytes using the phenol-chloroform method2122. The genotyping of 9 SNPs was performed by PCR and RFLP.…”

Section: Methodsmentioning

confidence: 99%

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Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels

Aung

Yin

et al. 2014

Sci Rep

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This study aimed to detect the association between the MLX interacting protein-like (MLXIPL), BUD13 homolog (BUD13) and zinc finger protein 259 (ZNF259) single nucleotide polymorphisms (SNPs) and serum lipid levels in the Chinese Mulao and Han populations. Genotyping of 9 SNPs was performed in 825 Mulao and 781 Han participants. The genotype and allele frequencies of ZNF259 rs2075290 and rs964184, and BUD13 rs10790162 SNPs were different between the Mulao and Han populations (P < 0.001). The SNPs of ZNF259 rs2075290 and BUD13 rs10790162 were associated with serum total cholesterol levels; ZNF259 rs2075290 and rs964184, BUD13 rs10790162, and MLXIPL rs3812316 and rs13235543 were associated with triglyceride (TG); and MLXIPL rs35332062 was associated with apolipoprotein (Apo) A1 in the Mulaos (P < 0.006–0.001). However, in the Hans, the SNPs of ZNF259 rs2075290 and BUD13 rs10790162 were associated with serum TG levels; ZNF259 rs2075290 was associated with low-density lipoprotein cholesterol and the ApoA1/ApoB ratio (P < 0.006–0.001). Significant linkage disequilibria were noted among ZNF259 rs2075290 and rs964184 and BUD13 rs10790162, and between MLXIPL rs3812316 and rs13235543 (r2 > 0.05, P < 0.001). The haplotypes of A-C-G-A-C (rs2075290A-rs964184C-rs10790162G-rs17119975A-rs11556024C) and C-C-C-C (rs799161C-rs35332062C-rs3812316C-rs13235543C) accounted for over half of the % haplotype of each ethnic group.

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Section: Methodsmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Genomic DNA was isolated from peripheral blood leukocytes using the phenol-chloroform method2122. The genotyping of 9 SNPs was performed by PCR and RFLP.…”

Section: Methodsmentioning

confidence: 99%

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Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels

Aung

Yin

et al. 2014

Sci Rep

Self Cite

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“…También las catequinas del té son eficientes en disminuir en forma significativa los niveles de colesterol (Kim et al, 2011). Sin embargo, a pesar de los muchos estudios que muestran cambios en el sentido de regular los niveles de colesterol por el efecto de sustancias bioactivas de la dieta, es preciso notar que la respuesta de los individuos a los nutrientes no es común a todas las poblaciones, debido a diferencias polimórficas de varios genes que participan en el metabolismo lipídico, como el del colesterol (Aung et al, 2011;Kotani et al, 2011;Pan et al, 2012), o a modificaciones postranscripcionales de los productos génicos (Medina et al, 2011).…”

Section: Srebp-2 Srebp-1cunclassified

El metabolismo del colesterol: cada vez más complejo

Sanhueza¹,

Valenzuela²,

Valenzuela³

2012

Grasas y Aceites

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373circulating cholesterol and once inside the body, there should be a perfect harmony between the addition of cholesterol to various tissues, its metabolic use, the mechanisms of its tissue deposition, and the synthesis of this lipid. From this perspective, this review offers a general view of the molecular mechanisms that allow the regulation of extra and intracellular cholesterol levels. KEY-WORDS: Cholesterol -Extracellular metabolism -Intracellular metabolism -Transport. INTRODUCCIÓNDesde su descubrimiento en 1769 por el fisiólo-go Francoise Poulletier de la Salle, el colesterol ha sido motivo de numerosos estudios, investigaciones y publicaciones (Olson, 1998). Hoy sabemos más sobre su digestión, biosíntesis, sus importantes funciones bioquímicas, su regulación y su participación en el origen de numerosas enfermedades (cardio y cerebro vasculares, neurológicas, inflamatorias, etc). Sin embargo, solo en forma más reciente se han descubierto, y entendido, los intrincados mecanismos moleculares que regulan su transporte fuera y dentro de las células, los mecanismos regulatorios en los cuales interviene y las numerosas moléculas que además del colesterol intervienen en estos procesos. El propósito de esta revisión es analizar lo que hoy día sabemos sobre estos últimos aspectos. DIGESTION Y ABSORCION DEL COLESTEROLEl 90-95% del colesterol que consumimos en la dieta está esterificado, por lo cual la enzima colesterol esterasa de origen pancreático lo libera en el intestino delgado (Howles et al., 1996). Una vez incorporado a las micelas mixtas, es transferido activamente a los enterocitos a través de la proteína transportadora Niemann-Pick C1 tipo 1 (NPC1) que se ubica en la membrana apical de los enterocitos y también en la membrana canalicular de los hepa- El colesterol es una molécula importante; es necesario para la biosíntesis de hormonas esteroideas, de sales biliares y para mantener la estabilidad de las membranas biológicas en células animales. Sin embargo, su exceso es negativo y es responsable de generar enfermedades que comprometen al corazón, al cerebro o que generan algunos tipos de cáncer. Por estos motivos, los niveles de colesterol celulares deben estar finamente regulados, y para ello, participan una infinidad de mecanismos que comprometen al organismo como un todo. Estos mecanismos deben comenzar a operar en forma eficiente desde la ingesta de colesterol dietario para su incorporación al enterocito, donde están implicados transportadores de tipo ABC y NCP1, los motivos estructurales PDZ, entre otras. También debe estar adecuadamente regulado el colesterol circulante y una vez en el interior del organismo, debería establecerse una perfecta armonía entre la incorporación del colesterol a los diversos tejidos, con su utilización metabólica, la generación de reservas de colesterol en los mismos y la síntesis de este lípido. Desde esta perspectiva, la presente revisión ofrece una visión general de los mecanismos moleculares que permiten la regulación de los niveles de colesterol a nivel extra e intr...

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Association of the apolipoprotein M gene polymorphisms and serum lipid levels

Aung

Yin

et al. 2012

Mol Biol Rep

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The association of rs707921 and rs707922 SNPs in the apolipoprotein M (APOM) gene and serum lipid levels is still controversial. This study aimed to detect the association of the APOM rs707921 and rs707922 SNPs and several environmental factors with serum lipid profiles. Genotyping of rs707921 and rs707922 was performed in 703 of Mulao's and 707 of Han's participants. The serum levels of TG in Mulao, and TG and HDL-C in Han were different between the A and C allele carriers of rs707921 (P < 0.05-0.01); while the serum levels of TG in both Mulao and Han were different between the T and G allele carriers of rs707922 (P < 0.05-0.01). According to the gender-subgroup analysis, the levels of TC in Mulao females, TG and ApoB in Han males, and HDL-C in Han females were associated with the genotypes of rs707921 (P < 0.05 for each); whereas the levels of TG in Mulao males, and TG and ApoB in Han males were correlated with the genotypes of rs707922 (P < 0.05 for each). Serum lipid parameters were also associated with several environmental factors (P < 0.05-0.001). The APOM gene rs707921 and rs707922 SNPs are associated with some serum lipid parameters in the two ethnic groups, but the trends of association suggest that the two SNPs might have racial/ethnic- and/or gender- specificity.

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Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations

Cited by 23 publications

References 44 publications

Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels

Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels

El metabolismo del colesterol: cada vez más complejo

Association of the apolipoprotein M gene polymorphisms and serum lipid levels

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