Association of the apolipoprotein M gene polymorphisms and serum lipid levels

Abstract

The association of rs707921 and rs707922 SNPs in the apolipoprotein M (APOM) gene and serum lipid levels is still controversial. This study aimed to detect the association of the APOM rs707921 and rs707922 SNPs and several environmental factors with serum lipid profiles. Genotyping of rs707921 and rs707922 was performed in 703 of Mulao's and 707 of Han's participants. The serum levels of TG in Mulao, and TG and HDL-C in Han were different between the A and C allele carriers of rs707921 (P < 0.05-0.01); while the serum levels of TG in both Mulao and Han were different between the T and G allele carriers of rs707922 (P < 0.05-0.01). According to the gender-subgroup analysis, the levels of TC in Mulao females, TG and ApoB in Han males, and HDL-C in Han females were associated with the genotypes of rs707921 (P < 0.05 for each); whereas the levels of TG in Mulao males, and TG and ApoB in Han males were correlated with the genotypes of rs707922 (P < 0.05 for each). Serum lipid parameters were also associated with several environmental factors (P < 0.05-0.001). The APOM gene rs707921 and rs707922 SNPs are associated with some serum lipid parameters in the two ethnic groups, but the trends of association suggest that the two SNPs might have racial/ethnic- and/or gender- specificity.

Association between the MLX Interacting Protein-Like, BUD13 Homolog and Zinc Finger Protein 259 Gene Polymorphisms and Serum Lipid Levels

“…All determinations were performed with an autoanalyzer (Type 7170A; Hitachi Ltd., Tokyo, Japan) in the Clinical Science Experiment Center of the First Affiliated Hospital, Guangxi Medical University. The normal values of serum TC, TG, HDL-C, LDL-C, ApoA1 and ApoB levels and the ratio of ApoA1 to ApoB in our Clinical Science Experiment Center were 3.10–5.17, 0.56–1.70, 1.16–1.42, 2.70–3.10 mmol/L, 1.20–1.60, 0.80–1.05 g/L and 1.00–2.50, respectively2122.…”

“…It has been noted that the genotype and allele frequencies of several SNPs are not consistent among different populations8919202122. The G allele frequency of MLXIPL rs3812316 (Q241H) SNP was 0.05 in Mexicans41, 0.10 in Europeans18 and 0.09 in Indian Asians18 and Japanese individuals23.…”

“…The consent procedure was also approved by the Ethics Committee of the First Affiliated Hospital, Guangxi Medical University. An incentive of approximately ten dollars was provided to each participant in the study19202122.…”

“…Genomic DNA was isolated from peripheral blood leukocytes using the phenol-chloroform method2122. The genotyping of 9 SNPs was performed by PCR and RFLP.…”

Beyond the Genetics of HDL: Why Is HDL Cholesterol Inversely Related to Cardiovascular Disease?

“…These results have recently been supported by evidence in plasma of humans (Plomgaard et al 2009) while others have found that human APOM gene variation affects HDL cholesterol (Park et al 2013;Aung et al 2013). Through carrying sphingosine-1-phosphate with effects on angiogenesis, endothelial cell migration, and inflammation, apoM (Christoffersen and Nielsen 2013) may be a link to many of the functions that are attributed to HDL.…”